Results 51 to 60 of about 26,955,799 (314)

Data-Driven Phenotyping: Graphical models for model-based phenotyping of sleep apnea [PDF]

IEEE Pulse, 2014
Sleep apnea is a multifactorial disease with a complex underlying physiology, which includes the chemoreflex feedback loop controlling ventilation. The instability of this feedback loop is one of the key factors contributing to a number of sleep disorders, including Cheyne?Stokes respiration and obstructive sleep apnea (OSA).
Shamin, Nemati, Jeremy, Orr, Atul, Malhotra   +2 more
openaire   +2 more sources

Rapid degeneration of Drosophila olfactory neurons in Orco mutant maxillary palps

microPublication Biology, 2021
Drosophila melanogaster vinegar flies have two olfactory organs: the antenna and maxillary palp. Olfactory neurons in these tissues respond to odorants via odorant receptors.
Darya Task, Christopher J Potter
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data [PDF]

Mammalian Genome, 2012
The Mammalian Phenotype Ontology (MP) is a structured vocabulary for describing mammalian phenotypes and serves as a critical tool for efficient annotation and comprehensive retrieval of phenotype data. Importantly, the ontology contains broad and specific terms, facilitating annotation of data from initial observations or screens and detailed data ...
Smith, Cynthia L, Eppig, Janan T
openaire   +3 more sources

Differential effects on neuromuscular physiology between Sod1 loss-of-function mutation and paraquat-induced oxidative stress in Drosophila

microPublication Biology, 2021
Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of Superoxide dismutase 1 (Sod1) and by paraquat (PQ) feeding in Drosophila.
Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu   +2 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

PhenCode: connecting ENCODE data with mutations and phenotype

Human Mutation, 2007
PhenCode (Phenotypes for ENCODE; http://www.bx.psu.edu/phencode) is a collaborative, exploratory project to help understand phenotypes of human mutations in the context of sequence and functional data from genome projects. Currently, it connects human phenotype and clinical data in various locus-specific databases (LSDBs) with data on genome sequences,
Giardine, B, Riemer, C, Hefferon, T, Thomas, D, Hsu, F, Zielenski, J, Sang, YH, Elnitski, L, Cutting, G, Trumbower, H, Kern, A, Kuhn, R, Patrinos, George, Hughes, J, Higgs, D, Chui, D, Scriver, C, Phommarinh, M, Patnaik, SK, Blumenfeld, O, Gottlieb, B, Vihinen, M, Valiaho, J, Kent, J, Miller, W, Hardison, RC   +25 more
openaire   +4 more sources

Nociceptor activity is required for a robust immune response in Drosophila larvae

microPublication Biology
The nervous system and the immune system play a shared role in defending Drosophila larvae against injury and infection. Potentially harmful stimuli are detected by nociceptive neurons that trigger escape behaviors, while wounds and foreign invaders are ...
Lydia J. Borjon, W. Daniel Tracey
doaj   +1 more source

ARF19 Condensation in the Arabidopsis Stomatal Lineage

microPublication Biology, 2023
The phytohormone auxin regulates nearly every aspect of plant development. Transcriptional responses to auxin are driven by the activities of the AUXIN RESPONSE FACTOR family of transcription factors.
Chi Kuan, Lucia C. Strader, Nicholas Morffy   +2 more
doaj   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source