Results 71 to 80 of about 26,955,799 (314)

Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype [PDF]

, 2011
Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea, behavioral disturbances and dementia, caused by a pathological expansion of the CAG trinucleotide in the HTT gene. Several patients have been recognized with the typical
Lopes-Cendes, Iscia, Odile Russaouen, Cécile Cazeneuve, Cazeneuve, Cécile, Walker R.H., Russaouen O., Bader B., Guilherme Riccioppo Rodrigues, Brice A., Russaouen, Odile, Tumas, Vitor, Wilson Marques Jr., Rodrigues G.R., Iscia Lopes-Cendes, Danek, Adrian, Adrian Danek, MARQUES JR., Wilson, Brice, Alexis, Marques Jr. W., Marques, Wilson, Vitor Tumas, Walker, Ruth H., Bader, Benedikt, Benedikt Bader, Danek A., Cazeneuve C., Ruth H. Walker, Riccioppo Rodrigues, Guilherme, RODRIGUES, Guilherme Riccioppo, Alexis Brice, Tumas V., Lopes-Cendes I.   +31 more
core   +1 more source

Genotype and Phenotype in Microtia (Supplementary Data)

, 2022
Genotype and Phenotype in Microtia (Supplementary ...
Wahdini, Siti Isya
core   +1 more source

Prostaglandins limit nuclear actin rod formation during Drosophila oogenesis

microPublication Biology
Expression of GFP-Actin results in nuclear actin rod formation during specific stages of Drosophila melanogaster oogenesis. Loss of prostaglandin (PG) synthesis and signaling results in an increased frequency of cells with nuclear actin rods; there are ...
Tina L. Tootle
doaj   +1 more source

EID1 promotes the response to canopy shade in Arabidopsis thaliana by repressing the action of phytochrome A

microPublication Biology, 2023
The phytochrome (phy) system enables plants to adapt to canopy shade. By sensing the reduction of the red:far-red light ratio in shade, phyA and phyB trigger downstream signalling cascades which eventually lead to enhanced elongation growth.
Anne-Marie Staudt, Thomas Kretsch, Andreas Hiltbrunner   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Extracellular matrix remodeling in atopic dermatitis harnesses the onset of an asthmatic phenotype and is a potential contributor to the atopic march

, 2023
Supplementary Data Sets for the manuscript: Graff et al., Extracellular matrix remodeling in atopic dermatitis harnesses the onset of an asthmatic phenotype and is a potential contributor to the atopic marchTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ...
Hedtrich, S (via Mendeley Data), Hedtrich, Sarah   +1 more
core   +1 more source

A Data-capture Tool for Mouse Pathology Phenotyping [PDF]

Veterinary Pathology, 2009
The Mouse Disease Information System is a free Microsoft Access database (http://research.jax.org/faculty/sundberg/index.html) designed by veterinary pathologists to aid veterinary pathologists in data acquisition, analysis, and coordination of tissue-sample archives.
Sundberg, B A, Schofield, P N, Gruenberger, M, Sundberg, J P   +3 more
openaire   +2 more sources

Determination of minimum inhibitory and lethal concentrations of two lactic acid bacteria Lactiplantibacillus plantarum reveals strain-specific antibiotic resistance

microPublication Biology
Lactic acid bacteria (LAB) are widely used as probiotics and in fermented foods, yet their antibiotic resistance profiles remain under-characterized.
Maria V. Mendoza-Dasilva, Lorraine Rodriguez-Rivera, Imilce A. Rodriguez-Fernandez   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source