Results 91 to 100 of about 26,955,799 (314)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

survival and phenotype data

, 2016
survival and phenotype data for experiments from coffs harbour (CH) and Lennox Head ...
Katrina McGuigan (3201174), Ortiz-Barrientos, Daniel, Thomas J. Richards (3194799), Richards, Thomas J., McGuigan, Katrina, Walter, Gregory M., Gregory M. Walter (3194796), Daniel Ortiz-Barrientos (5247)   +7 more
core   +1 more source

Phenotype-Informed Noncoding Element Scoring

, 2018
<p>Functional characterization of the noncoding genome is essential for the biological understanding of gene regulation and disease. Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring) which predicts ...
Bodea, Corneliu (5515433), Bodea, Corneliu   +1 more
core   +2 more sources

Wounding increases nuclear ploidy in wound-proximal epidermal cells of the Drosophila pupal notum

microPublication Biology
After injury, tissues must replace cell mass and genome copy number. The mitotic cycle is one mechanism for replacement, but non-mitotic strategies have been observed in quiescent tissues to restore tissue ploidy after wounding.
James White, M. Shane Hutson, Andrea Page-McCaw   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Dispersal phenotype data

, 2016
Data supporting Figure 1b: dispersal phenotype function of population density and cooperation ...
Delphine Legrand (178333), Nicolas Schtickzelle (35054), Huet, Michele, Alexis Serge Chaine (3240537), Schtickzelle, Nicolas, Legrand, Delphine, Clobert, Jean, Wehi, Priscilla, Staffan Jacob (3198747), Chaine, Alexis Serge, Michele Huet (3198741), Jacob, Staffan, Priscilla Wehi (3198744), Jean Clobert (35057)   +13 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Phenotype and genotype data.

, 2018
Full phenotype and NPY4R copy number data for 558 individuals used in this study. (DOCX)
Dan Larhammar (61732), Johanna C. Andersson-Assarsson (5007212), Kateryna Shebanits (5066489), Lars Feuk (60288), Lena M. S. Carlsson (10451124), Ingrid Larsson (5066492)   +5 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source