Phenotypic Plasticity in Bacterial Plasmids [PDF]
Genetics, 2004 AbstractPlasmid pB15 was previously shown to evolve increased horizontal (infectious) transfer at the expense of reduced vertical (intergenerational) transfer and vice versa, a key trade-off assumed in theories of parasite virulence. Whereas the models predict that susceptible host abundance should determine which mode of transfer is selectively ...
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Phenotype plasticity and altered sensitivity to chemotherapeutic agents in aggressive prostate cancer cells. [PDF]
Front Cell Dev Biol, 2023 Paxson AI +14 more
europepmc +1 more source
LIFE HISTORY SWITCH POINT PLASTICY IN RESPONSE TO POND DRYING ALYERS METAMORPH ALLOMETRY AND JUMPING PERFORMANCE [PDF]
, 2012 Animals with complex life cycles can cope with environmental uncertainty by altering life history switch points through developmental plasticity. Pond drying is an important factor which may alter life history switch points in aquatic organisms.
Charbonnier, Julie
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Cancer spreading patterns based on epithelial-mesenchymal plasticity
Frontiers in Cell and Developmental BiologyIntroduction: Metastasis is a major cause of cancer-related deaths, underscoring the necessity to discern the rules and patterns of cancer cell spreading. Epithelial-mesenchymal plasticity contributes to cancer aggressiveness and metastasis.
Rui Wang, Zhaopeng Yan
doaj +1 more source
Cancer Cell Phenotype Plasticity as a Driver of Immune Escape in Melanoma. [PDF]
Front Immunol, 2022 Benboubker V +3 more
europepmc +1 more source
Emerging strategies to target metastasis and therapy resistance in melanoma
Molecular Oncology, EarlyView.Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley +1 more source
Microglia subtypes show substrate- and time-dependent phagocytosis preferences and phenotype plasticity. [PDF]
Front Immunol, 2022 Li S +3 more
europepmc +1 more source
Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner [PDF]
, 2017 Background Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has
Benusa, S. D. +4 more
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Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source