Results 91 to 100 of about 294,085 (294)

Reverting ontogeny: rapid phenotypic plasticity of colour vision in cichlid fish [PDF]

Royal Society Open Science, 2019
Phenotypic plasticity, particularly during development, allows organisms to rapidly adjust to different environmental conditions. Yet, it is often unclear whether the extent and direction of plastic changes are restricted by an individual's ontogeny ...
Andreas Härer, Nidal Karagic, Axel Meyer, Julián Torres-Dowdall   +3 more
doaj   +1 more source

Can environmental conditions experienced in early life influence future generations? [PDF]

, 2014
The consequences of early developmental conditions for performance in later life are now subjected to convergent interest from many different biological sub-disciplines.
Burton, Tim, Metcalfe, Neil B.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Evidence for Snake Venom Plasticity in a Long-Term Study with Individual Captive Bothrops atrox

Toxins, 2019
Variability in snake venom composition has been frequently reported and correlated to the adaptability of snakes to environmental conditions. Previous studies report plasticity for the venom phenotype.
Diana R. Amazonas, Luciana A. Freitas-de-Sousa, Daniele P. Orefice, Leijiane F. de Sousa, Melissa G. Martinez, Rosa H. V. Mourão, Hipócrates M. Chalkidis, Plínio B. Camargo, Ana M. Moura-da-Silva   +8 more
doaj   +1 more source

Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. [PDF]

, 2019
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across organs shares
Ahadome, Sarah D, Aros, Cody J, Bhatt, Kush V, Chung, Katherine, Clark, Amander T, Damoiseaux, Robert, Darmawan, Kelly F, Durra, Abdo, Gomperts, Brigitte N, Graeber, Thomas G, Karumbayaram, Saravanan, Manze, Chase C, Mehrabi, Mehrsa, Minasyan, Aspram, Paul, Manash K, Rickabaugh, Tammy M, Sandlin, Jenna M, Shia, David W, Vijayaraj, Preethi, Wallace, W Dean, Wilkinson, Dan C, Yan, Weihong   +21 more
core   +1 more source

miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity [PDF]

, 2013
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function.
A Ucar, A Ucar, AD Wingate, Andrew Macdonald, AS Nudelman, BG Frenguelli, Bruno G. Frenguelli, BW Luikart, C Deplagne, CE Monk, Colin McKenzie, D Edbauer, D Lagos, G Neves, GA Wayman, GR Wiggin, Gyorgy Hutvagner, HI Im, HK Lee, HY Cheng, I Shaked, J Darragh, J Remenyi, J. Simon C. Arthur, JA Hollander, JC Strum, JS Arthur, JS Arthur, Judit Remenyi, K Wibrand, KD Taganov, KF Hansen, LA O’Neill, M Pathania, ME Klein, Mirjam W. M. van den Bosch, MR Fabian, N Mellios, N Vo, Oleg Palygin, P Tognini, R Zaragoza, Rajen B. Mistry, S Anand, S Impey, SA Correa, ST Magill, Thomas Preiss, TJ Lambert, V Molnar, VA Beardmore, VM Ho, VN Kim, WW Anderson, Y Pankratov, YM Clovis, Yuriy Pankratov, YV Pankratov   +57 more
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Comprehending phenotypic plasticity in cancer and evolution

iScience
Organisms as well as cancer cells are adept at adapting to changes in the environment in which they find themselves, by actively adjusting their phenotype.
Prakash Kulkarni, Ravi Salgia
doaj   +1 more source

Microenvironment-derived factors driving metastatic plasticity in melanoma

Nature Communications, 2017
Phenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state.
Isabella S. Kim, Silja Heilmann, Emily R. Kansler, Yan Zhang, Milena Zimmer, Kajan Ratnakumar, Robert L. Bowman, Theresa Simon-Vermot, Myles Fennell, Ralph Garippa, Liang Lu, William Lee, Travis Hollmann, Joao B. Xavier, Richard M. White   +14 more
doaj   +1 more source

Transgenerational Plasticity in the Context of Predator-Prey Interactions

Frontiers in Ecology and Evolution, 2020
Almost all animal species are engaged in predator-prey interactions. These interactions, variable in time and space, favor the emergence and evolution of phenotypic plasticity, which allows prey to fine-tune their phenotype to the current risk of ...
Juliette Tariel, Sandrine Plénet, Émilien Luquet   +2 more
doaj   +1 more source