Results 11 to 20 of about 149,168 (238)
Melanoma Plasticity: Promoter of Metastasis and Resistance to Therapy
Frontiers in Oncology, 2021 Melanoma is the deadliest form of skin cancer. Although targeted therapies and immunotherapies have revolutionized the treatment of metastatic melanoma, most patients are not cured. Therapy resistance remains a significant clinical challenge.
Fan Huang +8 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2020 Many neural mechanisms regulate experience-dependent plasticity in the visual cortex (V1), and new techniques for quantifying large numbers of proteins or genes are transforming how plasticity is studied into the era of big data.
Justin L. Balsor +4 more
doaj +1 more source
Molecular Oncology, 2021 Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple‐negative breast cancer (TNBC).
Anna Barkovskaya +12 more
doaj +1 more source
Biomolecules, 2021 Melanoma phenotype plasticity underlies tumour dissemination and resistance to therapy, yet its regulation is incompletely understood. In vivo switching between a more differentiated, proliferative phenotype and a dedifferentiated, invasive phenotype is ...
Vladimír Čermák +7 more
doaj +1 more source
Phenotypic plasticity of the body shape in wild and farmed common carp (Cyprinus carpio) using geometric morphometric method [PDF]
بومشناسی آبزیان, 2022 The aim of this study was to investigate the body shape and morphological comparison between the populations of wild (marine) and farmed common carp using geometric morphology.
Roya Bakhtiar +4 more
doaj
Direct and indirect induction of a compensatory phenotype that alleviates the costs of an inducible defense. [PDF]
PLoS ONE, 2007 Organisms often exhibit phenotypic plasticity in multiple traits in response to impending environmental change. Multiple traits phenotypic plasticity is complex syndrome brought on by causal relations in ecological and physiological context.
Tadashi Iwami +2 more
doaj +1 more source
Phenotypic Plasticity in Vertebrate Dentitions [PDF]
Integrative and Comparative Biology, 2020 SynopsisVertebrates interact directly with food items through their dentition, and these interactions with trophic resources could often feedback to influence tooth structure. Although dentitions are often considered to be a fixed phenotype, there is the potential for environmentally induced phenotypic plasticity in teeth to extensively influence their
Nidal Karagic +2 more
openaire +4 more sources
Phenotypic plasticity during metastatic colonization
Trends in Cell Biology, 2022 Most solid cancer-related deaths result from metastasis, a multistep process in which cancer cells exit the primary site, intravasate into the bloodstream, extravasate, and colonize distant organs. Colonization is facilitated by clonal selection and the high phenotypic plasticity of cancer cells that creates reversible switching of cellular states ...
Jehanno, Charly +4 more
openaire +2 more sources
Understanding and leveraging phenotypic plasticity during metastasis formation
npj Systems Biology and Applications, 2023 Cancer metastasis is the process of detrimental systemic spread and the primary cause of cancer-related fatalities. Successful metastasis formation requires tumor cells to be proliferative and invasive; however, cells cannot be effective at both tasks ...
Saumil Shah +5 more
doaj +1 more source
Insects, 2022 Developmental plasticity refers to the property by which a genotype corresponds to distinct phenotypes depending on the environmental conditions experienced during development.
Ana Rita Amaro Mateus, Patrícia Beldade
doaj +1 more source