Results 61 to 70 of about 173,452,781 (258)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic. [PDF]

Recognizing the influence of pathogen diversity on infection dynamics is crucial for mitigating emerging infectious diseases. Characterising such diversity is often complex, for instance when multiple pathogen variants exist that interact differently ...
Steinfartz, Sebastian, Lötters, Stefan, Pasmans, Frank, Frank Pasmans, Erens, Jesse, Sebastian Steinfartz, An Martel, Jesse Erens, Moira Kelly, Cuomo, Christina A., Vanessa Schulz, Marleen Foubert, Veith, Michael, Michael Veith, Kelly, Moira, Li, Zhimin, Stefan Lötters, Foubert, Marleen, Schulz, Vanessa, Van Praet, Sarah, Wouter Beukema, Salvador Carranza, Zhimin Li, Christina A Cuomo, Martell, José María, Carranza, Salvador, Sarah Van Praet, Beukema, Wouter, Martel, An, Loetters, Stefan   +29 more
core   +1 more source

Genetic Variability and Correlation for Quantitative Traits of Chickpea Genotypes (Cicer arietinum L.)

International Journal of Bio-Resource and Stress Management
The present study was conducted using 124 genotypes of chickpea (Cicer arietinum L.) during rabi, 2019–2020 at Regional Research Station, Faculty of Agriculture, Wadura, Sopore, SKUAST-K to assess the variability, correlation among yield and yield ...
Madhu Saatu, Hima Kumar Anakali, Shaik Faheem Akhtar, Mohammad Ashraf Bhat   +3 more
doaj   +1 more source

Characterisation of sweet stem sorghum genotypes for bio-ethanol production

Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2018
In an effort to characterise and select promising sweet stem sorghum genotypes with enhanced biofuel productivity, the present study investigated phenotypic variability present among diverse sweet stem sorghum genotypes based on ethanol production and ...
Precious Mangena, Hussein Shimelis, Mark Laing   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Genetic variability and character association among morpho-metric traits and essential oil constituents in eight half-sib seed progenies of peppermint (Mentha piperita L.)

Trends in Phytochemical Research, 2020
Menthol rich with low menthofuran peppermint (Mentha piperita L.) genotype MPK-5 and their eight half-sib seed progenies were evaluated for different genetic parameters, namely coefficient of variation, genetic advance, heritability, associations, and ...
Priyanka Prasad, Ram Kishor, Akancha Gupta, Vidhi Saxena, Sameen Zaidi, Himanshu Kushwaha, Vagmi Singh, Ram Swaroop Verma, B. Kumar   +8 more
doaj  

Variability, heritability and genetic advance for yield and quality components in interspecific F1 hybrids of cotton

Electronic Journal of Plant Breeding, 2017
Assessment of genetic variability using appropriate parameters like phenotypic coefficient of variation (PCV), genotypic coefficient of variation (GCV), heritability (h2), and genetic advance (GA) are really necessary to start an efficient breeding ...
Isong Abasianyanga and, P. Amala Balu
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Phenotypic and Agromorphological Diversity Reveals Detailed Information About Accessions with Productive Potential for Cotton (Gossypium barbadense L.) in Northeastern Peru

Plants
Cotton (Gossypium barbadense L.) is a crop of great economic importance, as the superior quality of its fiber is highly valued worldwide. The objective of this research was to evaluate the agromorphological diversity of cotton germplasm using both ...
Deyvis Córdova-Sinarahua, Susan Linares-Huapaya, Emma Imelda Manco-Céspedes   +2 more
doaj   +1 more source

Phenotypic diversity in natural populations of an endangered plant Tetracentron sinense

Botan‪ical Sciences, 2017
Background: Tetracentron sinense, distributed mainly in central and southwest China, is a threatened deciduous broad-leaved canopy tree. Presently, little is known about the phenotypic diversity in natural populations of T.
Hongyan Han, Shan Li, Xiaohong Gan, Xuemei Zhang   +3 more
doaj   +1 more source