Results 121 to 130 of about 536,745 (332)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Phenotypic Correlations Between External Egg Quality Traits in Native Ducks and Geese

open access: yesContemporary Agriculture
The aim of this research was to evaluate the phenotypic correlations between external egg quality traits in native duck and goose populations reared in Bosnia and Herzegovina.
Vekić Marinko, Jovičić Marija
doaj   +1 more source

THE INFLUENCE OF FOLIAR DAMAGE BY THE FALL ARMYWORM ON TRANSGENIC AND CONVENTIONAL MAIZE HYBRIDS

open access: yesUNINGÁ Review, 2019
With the large-scale emergence of diseases and pests in maize crops, the best solution to maintain maize yield and quality has been the use of Bt(Bacillus thuringiensis) technology, since it is a tactic which reduces the issues arising from ...
Cristiani Santos Bernini   +2 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Genotype‐Phenotype Correlations [PDF]

open access: yes, 2005
Julia E. Richards, R. Scott Hawley
openaire   +2 more sources

Biophysical constraints determine the selection of phenotypic fluctuations during directed evolution

open access: yes, 2018
Phenotypes of individuals in a population of organisms are not fixed. Phenotypic fluctuations, which describe temporal variation of the phenotype of an individual or individual-to-individual variation across a population, are present in populations from ...
Fraebel, David T.   +4 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Exploring the relationship between predicted negative energy balance and its biomarkers of Holstein cows in first-parity early lactation

open access: yesJournal of Dairy Science
: The negative energy balance (NEB) state in dairy cows is a critical factor affecting health, reproduction, and production, particularly during early lactation. Multiple blood and milk biomarkers change when dairy cows are in the NEB state.
Hongqing Hu   +8 more
doaj   +1 more source

Evaluation and development of animal breeding in Ireland [PDF]

open access: yes, 2008
End of project reportThe primary objectives of this study were: 1) to annually evaluate the pertinence of the Irish dairy cattle breeding index, the Economic Breeding Index (EBI) and where necessary modify, 2) to evaluate the potential of do-it-yourself ...
Berry, Donagh   +2 more
core  

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