Results 51 to 60 of about 4,546,004 (334)

Genotype/phenotype correlation in hereditary spherocytosis

Haematologica, 2008
Red blood cells are biconcave under physiological conditions but their shape changes when navigating narrow blood vessels or confined spaces in tissue and organs (such as the spleen). The ability of a red cell to maintain its discoid shape, elasticity and deformability in the circulation ...
IOLASCON, ACHILLE, Avvisati R.A.
openaire   +5 more sources

Nephronophthisis: A review of genotype–phenotype correlation [PDF]

Nephrology, 2018
ABSTRACTNephronophthisis is an autosomal recessive cystic kidney disease and one of the most common genetic disorders causing end‐stage renal disease in children. Nephronophthisis is a genetically heterogenous disorder with more than 25 identified genes.
Yu‐Hong Tao, Fenglan Luo
openaire   +3 more sources

ASSOCIATIONS BETWEEN TRAITS IN FISÁLIS: A TOOL FOR INDIRECT SELECTION OF SUPERIOR PLANTS

Revista Brasileira de Fruticultura, 2017
Knowledge about associations between traits is fundamental for plant breeding, since indirect selection can accelerate the development of promising genotypes.
NICOLE TREVISANI, RITA CAROLINA DE MELO, MAURO PORTO COLLI, JEFFERSON LUÍS MEIRELLES COIMBRA, ALTAMIR FREDERICO GUIDOLIN   +4 more
doaj   +1 more source

Character association studies and path coefficient analysis for yield and yield attributing traits in Ridge gourd [Luffa acutangula (L.) Roxb.]

Electronic Journal of Plant Breeding, 2016
To know the association of various growths and yield attributing traits with the complex yield, eighteen genotype of ridge gourd were subjected to study the genotypic and phenotypic correlation and path analysis. High genotypic co-efficient of variation (
Shivanand B. Koppad, Mukesh Chavan and, Rekha Hallur   +2 more
doaj   +1 more source

Genotype–phenotype correlations in Darier disease: A focus on the neuropsychiatric phenotype [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2018
AbstractDarier disease (DD) is an autosomal dominant skin disorder caused by mutations in ATP2A2 encoding the sarco/endoplasmic reticulum Ca2+ ATPase Isoform 2 (SERCA2). Evidence of a population‐level association between DD and psychiatric disorders suggests that mutations in ATP2A2 may have pleiotropic effects on the brain as well as skin. Evidence of
Katherine Gordon‐Smith, Elaine Green, Detelina Grozeva, Sherine Tavadia, Nick Craddock, Lisa Jones   +5 more
openaire   +3 more sources

Seleção precoce de maracujazeiro pelo uso da correlação entre dados de produção mensal e anual Early selection in passion fruit using correlation data between monthly and annual productivity

Pesquisa Agropecuária Brasileira, 2008
O objetivo deste trabalho foi determinar épocas de avaliação da produtividade e de componentes da produção que permitam selecionar precocemente genótipos superiores de maracujazeiro.
Leonardo Duarte Pimentel, Neusa Maria Colauto Stenzel, Cosme Damião Cruz, Claudio Horst Bruckner   +3 more
doaj   +1 more source

GGCX-Associated Phenotypes: An Overview in Search of Genotype-Phenotype Correlations [PDF]

International Journal of Molecular Sciences, 2017
Gamma-carboxylation, performed by gamma-glutamyl carboxylase (GGCX), is an enzymatic process essential for activating vitamin K-dependent proteins (VKDP) with important functions in various biological processes. Mutations in the encoding GGCX gene are associated with multiple phenotypes, amongst which vitamin K-dependent coagulation factor deficiency ...
Eva De Vilder, Jens Debacker, Olivier Vanakker   +2 more
openaire   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Inter-association and path coefficient analysis for yield and yield attributing traits in ash gourd [Benincasa hispida (Thunb) Cogn.]

Electronic Journal of Plant Breeding
Twenty nine genotypes of ash gourd (land races and released varieties) were evaluated during summer season (March to July) of 2022 and 2023. The main objective of the study was to evaluate the inter-associations among 15 yield and yield attributing ...
Hament Thakur* and Vijay Kumar
doaj   +1 more source