Results 51 to 60 of about 288,998 (216)

Genetic analysis of fertility traits of Holstein dairy cattle in warm and temperate climate

open access: yesActa Scientiarum: Animal Sciences, 2016
The edited data set for the estimation of heritability, genetic and phenotypic correlations of fertility traits contained up to 23,402 records from 10,894 cows calved between 2001 and 2015.
Rabie Rahbar   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Phenotypic Matching Without Genetic Correlation in Dimorphic Legs of Bulb Mites

open access: yesEcology and Evolution
The evolution of exaggerated structures used as weapons in male–male contests often drives correlated changes in traits that compensate for their costs or enhance their benefits.
Diego Solano‐Brenes   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Effect of intra row spacings on estimates of phenotypic and genotypic correlation coefficients in cotton (Gossypium arboreum)

open access: yesThe Indian Journal of Agricultural Sciences, 2016
A field experiment was conducted on six Gossypium arboreum genotypes for two successive cropping seasons from 2011-2012 to 2012-2013 at Central Institute for Cotton Research, Regional Station, Sirsa, Haryana, India.
S L AHUJA   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Relationships among Yield Components and Selection Criteria for Seed Yield Improvement in Bush Bean (Phaseolus vulgaris L.)

open access: yesJournal of Agricultural Sciences, 2012
The aim of this research is to determine the relationship among yield and some yield components of dry bean using correlation and path coefficient analysis. The experiment was carried out in irrigated conditions during 2004-2005 and 2005-2006 at the East
Haluk Kulaz, Vahdettin Çiftçi
doaj  

Study on character association in Lens culinaris medik.

open access: yesElectronic Journal of Plant Breeding, 2021
A field trial with fifty genotypes of lentil was undertaken in Agriculture Farm of the Institute of Agriculture, Visva –Bharati University during two consecutive winters of the year 2017-18 and 2018-19, with an intention to find out the nature of the ...
Soumya Satpathy*, Sandip Debnath and Abinash Mishra
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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