Results 101 to 110 of about 832,396 (367)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Rapid evolution in response to introduced predators II: the contribution of adaptive plasticity
BMC Evolutionary Biology, 2007 Background Introductions of non-native species can significantly alter the selective environment for populations of native species, which can respond through phenotypic plasticity or genetic adaptation.
Knapp Roland A +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Sparse evidence for selection on phenotypic plasticity in response to temperature
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019 Phenotypic plasticity is frequently assumed to be an adaptive mechanism by which organisms cope with rapid changes in their environment, such as shifts in temperature regimes owing to climate change.
P. Arnold, A. Nicotra, L. Kruuk
semanticscholar +1 more source
Phenotypic Plasticity: From Microevolution to Macroevolution [PDF]
, 2014 This chapter starts with a short history of the concept of phenotypic plasticity (from the seventeenth century to present) in order to distinguish two distinct conceptions of plasticity: one more dynamic (or Aristotelian) according to which the notion has been described as a property inherent to life whose very organization depends upon it, and an ...
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
THE ART OF WAR: PATTERNS AND MECHANISMS UNDERLYING PREDATOR-INDUCED PLASTICITY OF AMPHIBIANS [PDF]
, 2013 Organisms often employ phenotypic plasticity as a strategy to cope with variable environments. This is particularly true of predation threats, wherein prey induce defenses to reduce detection or capture by predators.
Relyea, Rick A, Shaffery, Heather M
core
Can environmental conditions experienced in early life influence future generations? [PDF]
, 2014 The consequences of early developmental conditions for performance in later life are now subjected to convergent interest from many different biological sub-disciplines.
Burton, Tim, Metcalfe, Neil B.
core +1 more source
Frontiers in Ecology and Evolution, 2019 Developmental systems integrate inputs of variation from different origins into the observable variation of the resulting phenotype. Different components of phenotypic variation can be distinguished that correspond to those inputs, but the response of ...
C. Klingenberg
semanticscholar +1 more source