Results 101 to 110 of about 215,177 (294)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer

Cancer Cell International
Cellular plasticity enables cancer cells to adapt non-genetically, thereby preventing therapeutic success. The epithelial-mesenchymal transition (EMT) is a type of plasticity linked to resistance and metastasis.
Lauriane Muller, Frédérique Fauvet, Christelle Chassot, Francesca Angileri, Angèle Coutant, Cyril Dégletagne, Laurie Tonon, Pierre Saintigny, Alain Puisieux, Anne-Pierre Morel, Maria Ouzounova, Pierre Martinez   +11 more
doaj   +1 more source

Phenotypic plasticity of circadian entrainment under a range of light conditions

Neurobiology of Sleep and Circadian Rhythms, 2020
The response to a zeitgeber, particularly the light/dark cycle, may vary phenotypically. Phenotypic plasticity can be defined as the ability of one genome to express different phenotypes in response to environmental variation.
C.R.C. Moreno, K. Wright, Jr., D.J. Skene, F.M. Louzada   +3 more
doaj   +1 more source

Understanding intellectual disability through RASopathies [PDF]

, 2014
Intellectual disability, commonly known as mental retardation in the International Classification of Disease from World Health Organization, is the term that describes an intellectual and adaptive cognitive disability that begins in early life during the
Pagani, Mario Rafael, San Martín, Alvaro   +1 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Overcoming maladaptive plasticity through plastic compensation

Current Zoology, 2013
Most species evolve within fluctuating environments, and have developed adaptations to meet the challenges posed by environmental heterogeneity. One such adaptation is phenotypic plasticity, or the ability of a single genotype to produce multiple ...
Matthew R.J. MORRIS, Sean M. ROGERS
doaj  

Temperature acclimatisation of swimming performance in the European Queen Scallop [PDF]

, 2005
The phenotypic plasticity of muscle performance and locomotory physiology allows the maintenance of essential activity capacity in the face of environmental change, and has been demonstrated in a wide phylogenetic range of eurythermal vertebrates.
Allison, Angilletta, Arnott, Ball, Barbeau, Barbeau, Barbeau, Beddow, Beddow, Boadas, Brokordt, Bullock, Cheng, Else, Goldspink, Guderley, Hardewig, Hazel, Heap, Heap, Huey, Huey, Jayne, Johnson, Johnson, Johnston, Johnston, Johnston, Pearson, Scheiner, Temple, Watkins   +31 more
core   +1 more source

Phenotypic Plasticity in Bacterial Plasmids [PDF]

Genetics, 2004
AbstractPlasmid pB15 was previously shown to evolve increased horizontal (infectious) transfer at the expense of reduced vertical (intergenerational) transfer and vice versa, a key trade-off assumed in theories of parasite virulence. Whereas the models predict that susceptible host abundance should determine which mode of transfer is selectively ...
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Phenotypic Plasticity in Juvenile Jellyfish Medusae Facilitates Effective Animal–Fluid Interaction [PDF]

, 2010
Locomotion and feeding in marine animals are intimately linked to the flow dynamics created by specialized body parts. This interaction is of particular importance during ontogeny, when changes in behaviour and scale challenge the organism with shifts in
Colin, Sean, Costello, John H., Dabiri, J. O., Feitl, K. E., Nawroth, J. C.   +4 more
core   +1 more source