Results 81 to 90 of about 632,276 (294)

The relative effects of climatic drivers and phenotypic integration on phenotypic plasticity of a globally invasive plant

Frontiers in Plant Science
IntroductionUnderstanding the constraints of phenotypic plasticity can provide insights into the factors that limit or influence the capacity of an organism to respond to changing environments.
Xincong Chen, Jiayu Wang, Wenwen Liu, Yihui Zhang   +3 more
doaj   +1 more source

Polyploidy as a chromosomal component of stochastic noise: variable scalar multiples of the diploid chromosome complement in the invertebrate species Girardia schubarti from Brazil

Brazilian Journal of Biology, 2017
Chromosome stoichiometry, a form of genetic plasticity, specifically refers to variation in the standard diploid genomic composition of an individual or species.
E. G. F. Benya, A. M. Leal-Zanchet, J. Hauser   +2 more
doaj   +1 more source

pieterarnold/Patterns-of-plasticity: Data from: Patterns of phenotypic plasticity along a thermal gradient differ by trait type in an alpine plant

, 2022
Data files and R code for analyses and figures associated with the Functional Ecology publication: "Patterns of phenotypic plasticity along a thermal gradient differ by trait type in an alpine plant"
Pieter Arnold
core   +1 more source

The phenotypic plasticity of developmental modules [PDF]

EvoDevo, 2016
Organisms develop and evolve in a modular fashion, but how individual modules interact with the environment remains poorly understood. Phenotypically plastic traits are often under selection, and studies are needed to address how traits respond to the environment in a modular fashion.
Aabha I. Sharma, Katherine O. Yanes, Luyang Jin, Sarah L. Garvey, Sartu M. Taha, Yuichiro Suzuki   +5 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Identifying yield-related genes in maize based on ear trait plasticity

Genome Biology, 2023
Background Phenotypic plasticity is defined as the phenotypic variation of a trait when an organism is exposed to different environments, and it is closely related to genotype. Exploring the genetic basis behind the phenotypic plasticity of ear traits in
Minguo Liu, Shuaisong Zhang, Wei Li, Xiaoming Zhao, Xi-Qing Wang   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

[Phenotypic plasticity in insects].

Biologie aujourd'hui, 2020
Les insectes représentent 85 % des animaux. Ils se sont adaptés à de nombreux environnements et jouent un rôle majeur dans les écosystèmes. De nombreuses espèces d'insectes montrent de la plasticité phénotypique. Nous présentons ici les mécanismes impliqués dans la plasticité phénotypique chez différents insectes (les pucerons, le criquet migrateur, le
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source