Results 81 to 90 of about 111,624 (298)

Identifying yield-related genes in maize based on ear trait plasticity

Genome Biology, 2023
Background Phenotypic plasticity is defined as the phenotypic variation of a trait when an organism is exposed to different environments, and it is closely related to genotype. Exploring the genetic basis behind the phenotypic plasticity of ear traits in
Minguo Liu, Shuaisong Zhang, Wei Li, Xiaoming Zhao, Xi-Qing Wang   +4 more
doaj   +1 more source

RNA Directed Modulation of Phenotypic Plasticity in Human Cells.

, 2016
Natural selective processes have been known to drive phenotypic plasticity, which is the emergence of different phenotypes from one genome following environmental stimulation.
Laura Trakman, Jon Burdach, Hewson, Chris, Burdach, Jon, Jon Burdach (767393), Laura Trakman (2615446), Morris, Kevin V, Kevin V. Morris (79830), Trakman, Laura, Chris Hewson, Kevin V Morris, Chris Hewson (2615449)   +11 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Rapid evolution in response to introduced predators II: the contribution of adaptive plasticity

BMC Evolutionary Biology, 2007
Background Introductions of non-native species can significantly alter the selective environment for populations of native species, which can respond through phenotypic plasticity or genetic adaptation.
Knapp Roland A, Bakelar Jeremy W, Latta Leigh C, Pfrender Michael E   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Patterns of morphological and genetic variability in UK populations of the shore crab, Carcinus maenas Linnaeus, 1758 (Crustacea: Decapoda: Brachyura)

, 2006
Previous research has identified extensive inter-population variability in the morphology of the shore crab (Carcinus maenas L.). To determine the source of this variation (genetic or environmental), morphological and genetic data were analysed from ...
Todd, PA, Brian, J.V., Fernandes, T, Ladle, RJ, Brian, JV, Fernandes, T., Ladle, R.J., Todd, P.A.   +7 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

[Phenotypic plasticity in insects].

Biologie aujourd'hui, 2020
Les insectes représentent 85 % des animaux. Ils se sont adaptés à de nombreux environnements et jouent un rôle majeur dans les écosystèmes. De nombreuses espèces d'insectes montrent de la plasticité phénotypique. Nous présentons ici les mécanismes impliqués dans la plasticité phénotypique chez différents insectes (les pucerons, le criquet migrateur, le
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Phenotypic plasticity in nematodes [PDF]

Worm, 2012
Model systems, including C. elegans, have been successfully studied to understand the genetic control of development. A genotype's phenotype determines its evolutionary fitness in natural environments, which are typically harsh, heterogeneous and dynamic.
Viney, Mark, Diaz, Anaid
openaire   +3 more sources