Results 71 to 80 of about 665,969 (295)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Cancer cells exhibit clonal diversity in phenotypic plasticity [PDF]

Open Biology, 2017
Phenotypic heterogeneity in cancers is associated with invasive progression and drug resistance. This heterogeneity arises in part from the ability of cancer cells to switch between phenotypic states, but the dynamics of this cellular plasticity remain ...
Robert Austin Mathis, Ethan S. Sokol, Piyush B. Gupta   +2 more
doaj   +1 more source

Functional Mapping of Phenotypic Plasticity of Staphylococcus aureus Under Vancomycin Pressure

Frontiers in Microbiology, 2021
Phenotypic plasticity is the exhibition of various phenotypic traits produced by a single genotype in response to environmental changes, enabling organisms to adapt to environmental changes by maintaining growth and reproduction. Despite its significance
Dengcheng Yang, Xuyang Zheng, Libo Jiang, Libo Jiang, Meixia Ye, Meixia Ye, Xiaoqing He, Xiaoqing He, Yi Jin, Yi Jin, Rongling Wu, Rongling Wu, Rongling Wu   +12 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

THE ART OF WAR: PATTERNS AND MECHANISMS UNDERLYING PREDATOR-INDUCED PLASTICITY OF AMPHIBIANS [PDF]

, 2013
Organisms often employ phenotypic plasticity as a strategy to cope with variable environments. This is particularly true of predation threats, wherein prey induce defenses to reduce detection or capture by predators.
Shaffery, Heather M, Relyea, Rick A
core  

Ecological genetics of an induced plant defense against herbivores: additive genetic variance and costs of phenotypic plasticity [PDF]

, 2002
Adaptive phenotypic plasticity in chemical defense is thought to play a major role in plant-herbivore interactions. We investigated genetic variation for inducibility of defensive traits in wild radish plants and asked if the evolution of induction is ...
Johnson, M. T. J., Marc T. J. Johnson, Conner, J. K., Jeffrey K. Conner, Anurag A Agrawal, Wallsgrove, R. M., Anurag A. Agrawal, Marc T J Johnson, Agrawal, A. A., Roger Wallsgrove, Jeffrey K Conner   +10 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Should Root Plasticity Be a Crop Breeding Target?

Frontiers in Plant Science, 2020
Root phenotypic plasticity has been proposed as a target for the development of more productive crops in variable environments. However, the plasticity of root anatomical and architectural responses to environmental cues is highly complex, and the ...
Hannah M. Schneider, Jonathan P. Lynch
doaj   +1 more source

Adaptive Phenotypic Plasticity Stabilizes Evolution in Fluctuating Environments

Frontiers in Ecology and Evolution, 2021
Fluctuating environmental conditions are ubiquitous in natural systems, and populations have evolved various strategies to cope with such fluctuations. The particular mechanisms that evolve profoundly influence subsequent evolutionary dynamics.
Alexander Lalejini, Alexander Lalejini, Alexander Lalejini, Austin J. Ferguson, Austin J. Ferguson, Austin J. Ferguson, Nkrumah A. Grant, Nkrumah A. Grant, Charles Ofria, Charles Ofria, Charles Ofria   +10 more
doaj   +1 more source

Phenotypic plasticity during metastatic colonization

Trends in Cell Biology, 2022
Most solid cancer-related deaths result from metastasis, a multistep process in which cancer cells exit the primary site, intravasate into the bloodstream, extravasate, and colonize distant organs. Colonization is facilitated by clonal selection and the high phenotypic plasticity of cancer cells that creates reversible switching of cellular states ...
Jehanno, Charly, Vulin, Milica, Richina, Veronica, Richina, Federica, Bentires-Alj, Mohamed   +4 more
openaire   +3 more sources