Results 61 to 70 of about 665,969 (295)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Plasticity leaves a phenotypic signature during local adaptation
Evolution Letters, 2020 Phenotypic responses to a novel or extreme environment are initially plastic, only later to be followed by genetic change. Whether or not environmentally induced phenotypes are sufficiently recurrent and fit to leave a signature in adaptive evolution is ...
Reinder Radersma +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
CellsEarly-life brain injuries are major causes of long-term neurodevelopmental disorders such as cerebral palsy. Emerging evidence suggests these injuries can alter the gut microbiota composition, intestinal integrity, and neuroinflammatory responses.
Vanessa da Silva Souza +7 more
doaj +1 more source
Ecological consequences of phenotypic plasticity [PDF]
Trends in Ecology & Evolution, 2005 Phenotypic plasticity is widespread in nature, and often involves ecologically relevant behavioral, physiological, morphological and life-historical traits. As a result, plasticity alters numerous interactions between organisms and their abiotic and biotic environments.
Miner, Benjamin G +4 more
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
npj Parkinson's DiseaseParkinson’s disease (PD) is a progressive movement disorder with motor and non-motor symptoms, including gastrointestinal and olfactory dysfunctions. These symptoms may be associated with plasma concentrations of the hormone ghrelin.
Henrique José Cavalcanti Bezerra Gouveia +2 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Generalized Norms of Reaction for Ecological Developmental Biology [PDF]
, 2002 A standard norm of reaction (NoR) is a graphical depiction of the phenotypic value of some trait of an individual genotype in a population as a function of an environmental parameter. NoRs thus depict the phenotypic plasticity of a trait. The topological
Sarkar, Sahotra, Fuller, Trevon
core
, 2022 Data files and R code for analyses and figures associated with the Functional Ecology publication: "Patterns of phenotypic plasticity along a thermal gradient differ by trait type in an alpine plant"
Pieter Arnold
core +1 more source