Results 61 to 70 of about 111,624 (298)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cancer cells exhibit clonal diversity in phenotypic plasticity [PDF]
Open Biology, 2017 Phenotypic heterogeneity in cancers is associated with invasive progression and drug resistance. This heterogeneity arises in part from the ability of cancer cells to switch between phenotypic states, but the dynamics of this cellular plasticity remain ...
Robert Austin Mathis +2 more
doaj +1 more source
Adaptive plasticity in the mouse mandible [PDF]
, 2014 Background: Plasticity, i.e. non-heritable morphological variation, enables organisms to modify the shape of their skeletal tissues in response to varying environmental stimuli.
Sabrina Renaud +7 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Functional Mapping of Phenotypic Plasticity of Staphylococcus aureus Under Vancomycin Pressure
Frontiers in Microbiology, 2021 Phenotypic plasticity is the exhibition of various phenotypic traits produced by a single genotype in response to environmental changes, enabling organisms to adapt to environmental changes by maintaining growth and reproduction. Despite its significance
Dengcheng Yang +12 more
doaj +1 more source
The genetics of thermal plasticity in Plantago lanceolata [PDF]
, 2017 Phenotypic plasticity, an individual’s phenotypic response to environmental change, is a fundamental characteristic of all life on earth that plays a central role in adaptation, phenotypic differentiation, and speciation. Temperature-sensitive phenotypic
Marshall, Matthew M. +1 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Should Root Plasticity Be a Crop Breeding Target?
Frontiers in Plant Science, 2020 Root phenotypic plasticity has been proposed as a target for the development of more productive crops in variable environments. However, the plasticity of root anatomical and architectural responses to environmental cues is highly complex, and the ...
Hannah M. Schneider, Jonathan P. Lynch
doaj +1 more source
Adaptive Phenotypic Plasticity Stabilizes Evolution in Fluctuating Environments
Frontiers in Ecology and Evolution, 2021 Fluctuating environmental conditions are ubiquitous in natural systems, and populations have evolved various strategies to cope with such fluctuations. The particular mechanisms that evolve profoundly influence subsequent evolutionary dynamics.
Alexander Lalejini +10 more
doaj +1 more source
THE ART OF WAR: PATTERNS AND MECHANISMS UNDERLYING PREDATOR-INDUCED PLASTICITY OF AMPHIBIANS [PDF]
, 2013 Organisms often employ phenotypic plasticity as a strategy to cope with variable environments. This is particularly true of predation threats, wherein prey induce defenses to reduce detection or capture by predators.
Shaffery, Heather M, Relyea, Rick A
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