Results 91 to 100 of about 111,624 (298)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The REDOX balance in the prefrontal cortex is positively modulated by aerobic exercise and altered by overfeeding

Scientific Reports
While obesity rates increase worldwide, physical activity levels are reduced. Obesity and physical inactivity may be inversely related to the production of reactive oxygen species (ROS) and cause oxidative stress in the central nervous system.
Deyvison Guilherme Martins Silva, Jonata Henrique de Santana, Elenilson Maximino Bernardo, Matheus Santos de Sousa Fernandes, Fatma Hilal Yagin, Fahaid Al-Hashem, Mariana P. Fernandes, Jarlei Fiamoncini, Safaa M. Elkholi, Claudia J. Lagranha   +9 more
doaj   +1 more source

Weak gene–gene interaction facilitates the evolution of gene expression plasticity

BMC Biology, 2023
Background Individual organisms may exhibit phenotypic plasticity when they acclimate to different conditions. Such plastic responses may facilitate or constrain the adaptation of their descendant populations to new environments, complicating their ...
Hao-Chih Kuo, Cheng-Te Yao, Ben-Yang Liao, Meng-Pin Weng, Feng Dong, Yu-Cheng Hsu, Chih-Ming Hung   +6 more
doaj   +1 more source

Plant phenotypic plasticity in a changing climate

, 2010
Climate change is altering the availability of resources and the conditions that are crucial to plant performance. One way plants will respond to these changes is through environmentally induced shifts in phenotype (phenotypic plasticity).
Mathesius, Ulrike, F. Valladares, Finnegan, E J, Purugganan, Michael D., Poot, P., A.M. Davidson, M.D. Purugganan, Mathesius, U., O.K. Atkin, Atkin, O. K., E.J. Finnegan, C.L. Richards, Mathesius, U, Poot, Pieter, Richards, C.L., Valladares, F., Richards, Christina L., Finnegan, Jean, Bonser, Stephen P., Bonser, S. P., A.B. Nicotra, P. Poot, Davidson, Amy M., Nicotra, A.B., Finnegan, E.J., Kleunan, M Van, Davidson, A. M., Atkin, O.K., S.P. Bonser, M. van Kleunen, van Kleunen, Mark, Bonser, S.P., Davidson, A.M., Nicotra, Adrienne B., Atkin, Owen K., U. Mathesius, Purugganan, M.D., Poot, P, Nicotra, A. B., Valladares, Fernando, Purugganan, M D   +40 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Responding to environmental change: plastic responses vary little in a colonial breeder [PDF]

, 2006
The impact of environmental change on animal populations is strongly influenced by the ability of individuals to plastically adjust key life-history events.
Cunningham, Emma J. A., Harris, Michael P., Reed, Thomas E., Kruuk, Loeske E. B., Wanless, Sarah, Frederiksen, Morten   +5 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Phenotypic Plasticity in Bacterial Plasmids [PDF]

Genetics, 2004
AbstractPlasmid pB15 was previously shown to evolve increased horizontal (infectious) transfer at the expense of reduced vertical (intergenerational) transfer and vice versa, a key trade-off assumed in theories of parasite virulence. Whereas the models predict that susceptible host abundance should determine which mode of transfer is selectively ...
openaire   +2 more sources

Does plasticity enhance or dampen phenotypic parallelism? A test with three lake-stream stickleback pairs

, 2016
Parallel (and convergent) phenotypic variation is most often studied in the wild, where it is difficult to disentangle genetic vs. environmentally induced effects.
Oke, K.B., Hendry, A.P., Bukhari, M., Peichel, Catherine, Bolnick, D.I., Räsänen, K., Kaeuffer, R., Rolhausen, G.   +7 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source