Results 91 to 100 of about 665,969 (295)

Temperature acclimatisation of swimming performance in the European Queen Scallop [PDF]

, 2005
The phenotypic plasticity of muscle performance and locomotory physiology allows the maintenance of essential activity capacity in the face of environmental change, and has been demonstrated in a wide phylogenetic range of eurythermal vertebrates.
Bailey, DM, Bailey, D.M., Johnston, I.A., Johnston, Ian Alistair, Johnston, Ian Alistair; id_orcid   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Rapid evolution in response to introduced predators II: the contribution of adaptive plasticity

BMC Evolutionary Biology, 2007
Background Introductions of non-native species can significantly alter the selective environment for populations of native species, which can respond through phenotypic plasticity or genetic adaptation.
Knapp Roland A, Bakelar Jeremy W, Latta Leigh C, Pfrender Michael E   +3 more
doaj   +1 more source

Identifying yield-related genes in maize based on ear trait plasticity

Genome Biology, 2023
Background Phenotypic plasticity is defined as the phenotypic variation of a trait when an organism is exposed to different environments, and it is closely related to genotype. Exploring the genetic basis behind the phenotypic plasticity of ear traits in
Minguo Liu, Shuaisong Zhang, Wei Li, Xiaoming Zhao, Xi-Qing Wang   +4 more
doaj   +1 more source

Plant phenotypic plasticity in a changing climate

, 2010
Climate change is altering the availability of resources and the conditions that are crucial to plant performance. One way plants will respond to these changes is through environmentally induced shifts in phenotype (phenotypic plasticity).
Mathesius, Ulrike, F. Valladares, Finnegan, E J, Purugganan, Michael D., Poot, P., A.M. Davidson, M.D. Purugganan, Mathesius, U., O.K. Atkin, Atkin, O. K., E.J. Finnegan, C.L. Richards, Mathesius, U, Poot, Pieter, Richards, C.L., Valladares, F., Richards, Christina L., Finnegan, Jean, Bonser, Stephen P., Bonser, S. P., A.B. Nicotra, P. Poot, Davidson, Amy M., Nicotra, A.B., Finnegan, E.J., Kleunan, M Van, Davidson, A. M., Atkin, O.K., S.P. Bonser, M. van Kleunen, van Kleunen, Mark, Bonser, S.P., Davidson, A.M., Nicotra, Adrienne B., Atkin, Owen K., U. Mathesius, Purugganan, M.D., Poot, P, Nicotra, A. B., Valladares, Fernando, Purugganan, M D   +40 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The REDOX balance in the prefrontal cortex is positively modulated by aerobic exercise and altered by overfeeding

Scientific Reports
While obesity rates increase worldwide, physical activity levels are reduced. Obesity and physical inactivity may be inversely related to the production of reactive oxygen species (ROS) and cause oxidative stress in the central nervous system.
Deyvison Guilherme Martins Silva, Jonata Henrique de Santana, Elenilson Maximino Bernardo, Matheus Santos de Sousa Fernandes, Fatma Hilal Yagin, Fahaid Al-Hashem, Mariana P. Fernandes, Jarlei Fiamoncini, Safaa M. Elkholi, Claudia J. Lagranha   +9 more
doaj   +1 more source

[Phenotypic plasticity in insects].

Biologie aujourd'hui, 2020
Les insectes représentent 85 % des animaux. Ils se sont adaptés à de nombreux environnements et jouent un rôle majeur dans les écosystèmes. De nombreuses espèces d'insectes montrent de la plasticité phénotypique. Nous présentons ici les mécanismes impliqués dans la plasticité phénotypique chez différents insectes (les pucerons, le criquet migrateur, le
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source