Results 91 to 100 of about 632,276 (294)

The REDOX balance in the prefrontal cortex is positively modulated by aerobic exercise and altered by overfeeding

Scientific Reports
While obesity rates increase worldwide, physical activity levels are reduced. Obesity and physical inactivity may be inversely related to the production of reactive oxygen species (ROS) and cause oxidative stress in the central nervous system.
Deyvison Guilherme Martins Silva, Jonata Henrique de Santana, Elenilson Maximino Bernardo, Matheus Santos de Sousa Fernandes, Fatma Hilal Yagin, Fahaid Al-Hashem, Mariana P. Fernandes, Jarlei Fiamoncini, Safaa M. Elkholi, Claudia J. Lagranha   +9 more
doaj   +1 more source

Rapid evolution in response to introduced predators II: the contribution of adaptive plasticity

BMC Evolutionary Biology, 2007
Background Introductions of non-native species can significantly alter the selective environment for populations of native species, which can respond through phenotypic plasticity or genetic adaptation.
Knapp Roland A, Bakelar Jeremy W, Latta Leigh C, Pfrender Michael E   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Phenotypic plasticity and diversity in insects [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2010
Phenotypic plasticity in general and polyphenic development in particular are thought to play important roles in organismal diversification and evolutionary innovation. Focusing on the evolutionary developmental biology of insects, and specifically that of horned beetles, I explore the avenues by which phenotypic plasticity and polyphenic development ...
openaire   +2 more sources

Plant phenotypic plasticity in a changing climate

, 2010
Climate change is altering the availability of resources and the conditions that are crucial to plant performance. One way plants will respond to these changes is through environmentally induced shifts in phenotype (phenotypic plasticity).
Mathesius, Ulrike, F. Valladares, Finnegan, E J, Purugganan, Michael D., Poot, P., A.M. Davidson, M.D. Purugganan, Mathesius, U., O.K. Atkin, Atkin, O. K., E.J. Finnegan, C.L. Richards, Mathesius, U, Poot, Pieter, Richards, C.L., Valladares, F., Richards, Christina L., Finnegan, Jean, Bonser, Stephen P., Bonser, S. P., A.B. Nicotra, P. Poot, Davidson, Amy M., Nicotra, A.B., Finnegan, E.J., Kleunan, M Van, Davidson, A. M., Atkin, O.K., S.P. Bonser, M. van Kleunen, van Kleunen, Mark, Bonser, S.P., Davidson, A.M., Nicotra, Adrienne B., Atkin, Owen K., U. Mathesius, Purugganan, M.D., Poot, P, Nicotra, A. B., Valladares, Fernando, Purugganan, M D   +40 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source