Results 101 to 110 of about 632,276 (294)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Overcoming maladaptive plasticity through plastic compensation

Current Zoology, 2013
Most species evolve within fluctuating environments, and have developed adaptations to meet the challenges posed by environmental heterogeneity. One such adaptation is phenotypic plasticity, or the ability of a single genotype to produce multiple ...
Matthew R.J. MORRIS, Sean M. ROGERS
doaj  

EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer

Cancer Cell International
Cellular plasticity enables cancer cells to adapt non-genetically, thereby preventing therapeutic success. The epithelial-mesenchymal transition (EMT) is a type of plasticity linked to resistance and metastasis.
Lauriane Muller, Frédérique Fauvet, Christelle Chassot, Francesca Angileri, Angèle Coutant, Cyril Dégletagne, Laurie Tonon, Pierre Saintigny, Alain Puisieux, Anne-Pierre Morel, Maria Ouzounova, Pierre Martinez   +11 more
doaj   +1 more source

Increased phenotypic plasticity to climate may have boosted the invasion success of polyploid Centaurea stoebe.

PLoS ONE, 2012
Phenotypic plasticity may allow organisms to cope with altered environmental conditions as e.g. after the introduction into a new range. In particular polyploid organisms, containing more than two sets of chromosomes, may show high levels of plasticity ...
Min A Hahn, Mark van Kleunen, Heinz Müller-Schärer   +2 more
doaj   +1 more source

Impacts of sperm competition on mating behaviour and life history traits in a simultaneous hermaphrodite [PDF]

, 2013
Evolutionary theory suggests that post-copulatory sexual selection plays an important role in the evolution of reproductive traits of sexually reproducing animals.
Sandner, Peter
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Responding to environmental change: plastic responses vary little in a colonial breeder [PDF]

, 2006
The impact of environmental change on animal populations is strongly influenced by the ability of individuals to plastically adjust key life-history events.
Cunningham, Emma J. A., Harris, Michael P., Reed, Thomas E., Kruuk, Loeske E. B., Wanless, Sarah, Frederiksen, Morten   +5 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Phenotypic Plasticity [PDF]

, 2008
J. Howard Frank, J. Howard Frank, Michael C. Thomas, Allan A. Yousten, F. William Howard, Robin M. Giblin-davis, John B. Heppner, Robert L. Zuparko, Norma E. Sánchez, María G. Luna, Marta Goula, John B. Heppner, Andrey N. Alekseev, Rosalind R. James, John L. Capinera, Phyllis G. Weintraub, David Horton, J. Howard Frank, Kenneth W. Mccravy, David G. Riley, David C. Marshall, Cyrus Abivardi, Marjorie A. Hoy, Efat M. Abou-fakhr hammad, Jason G. Froeba, David Legg, Heather J. Mc Auslane, Qiao Wang, Cyrus Abivardi, Seth Bybee, Menachem J. Berlinger, Sarah Lebiush-mordechi, Harold A. Denmark, J. Howard Frank, Whitney Cranshaw, John L. Capinera, John B. Heppner, Chris Asaro, Erik Christiansen, William J. Roltsch, Dale E. Meyerdirk, Lewis B. Coons, Marjorie Rothschild, Minos E. Tzanakakis, Pauline O. Lawrence, Alfred G. Wheeler, Thomas J. Henry, Russell F. Mizell, Partricia A. Mizell, John B. Heppner, Lois B. O’ brien, Menachem J. Berlinger, Anthony Rossi, Wayne B. Hunter, Charles Vincent, Gérald Chouinard, Tracy Leskey, Deborah L. Matthews, Peter G. Kevan, Antonio Felicioli, Mauro Pinzauti, Olle Pellmyr, John T. Trumble, Danel B. Vickerman, Cyrus Abivardi, Robert McSorley, K. K. Verma, John L. Capinera, Peter H. Adler, Igor Uspensky, Donald W. Hall, John L. Capinera, Juan M. Alvarez, John L. Capinera, Eugene J. Gerberg, Lawrence E. Hurd, Lawrence E. Hurd, Patrick De Clercq, John B. Heppner, J. Howard Frank, Lawrence I. Gilbert, Robert Rybczynski, Christopher Tipping, James H. Tsai, Philip Weinstein, David Slaney, Peter H. Adler, Zeyaur R. Khan, John A. Pickett, John B. Heppner, Cyrus Abivardi, Katie Goodman, Kenneth W. McCravy, Andrei Sourakov   +93 more
  +5 more sources

Phenotypic Plasticity in Bacterial Plasmids [PDF]

Genetics, 2004
AbstractPlasmid pB15 was previously shown to evolve increased horizontal (infectious) transfer at the expense of reduced vertical (intergenerational) transfer and vice versa, a key trade-off assumed in theories of parasite virulence. Whereas the models predict that susceptible host abundance should determine which mode of transfer is selectively ...
openaire   +2 more sources