Results 111 to 120 of about 832,396 (367)
Phenotypic plasticity as a long-term memory easing readaptations to ancestral environments
Science Advances, 2020 From bacteria to vertebrates, organisms “remember” their ancestral environments in the form of phenotypic plasticity. Phenotypic plasticity refers to environment-induced phenotypic changes without mutation and is present in all organisms.
Wei-Chin Ho +3 more
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
International Journal of Molecular Sciences, 2019 Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a prognosis of 12–15 months and just 3–5% of survival over 5 years.
M. Fedele +4 more
semanticscholar +1 more source
Time to exploit phenotypic plasticity [PDF]
Journal of Experimental Botany, 2020 This article comments on:Diouf I, Derivot L, Koussevitzky S, Carretero Y, Bitton F, Moreau L, Causse M. 2020. Genetic basis of phenotypic plasticity and genotype×environment interaction in a multi-parental tomato population. Journal of Experimental Botany 71, 5365–5376.
openaire +6 more sources
Evolution of generalists by phenotypic plasticity [PDF]
iScience, 2019 AbstractAdapting organisms face a tension between specializing their phenotypes for certain ecological tasks or developing generalist strategies which permit persistence in multiple environmental conditions. Understanding when and how generalists or specialists evolve is therefore an important question in evolutionary dynamics.
Fraebel, David T. +3 more
openaire +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Weak gene–gene interaction facilitates the evolution of gene expression plasticity
BMC Biology, 2023 Background Individual organisms may exhibit phenotypic plasticity when they acclimate to different conditions. Such plastic responses may facilitate or constrain the adaptation of their descendant populations to new environments, complicating their ...
Hao-Chih Kuo +6 more
doaj +1 more source
Evolution of Robustness to Noise and Mutation in Gene Expression Dynamics [PDF]
, 2007 Phenotype of biological systems needs to be robust against mutation in order to sustain themselves between generations. On the other hand, phenotype of an individual also needs to be robust against fluctuations of both internal and external origins that ...
A Bar-Even +47 more
core +6 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source