Results 91 to 100 of about 188,733 (294)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Phenotypic variance within clusters of inbred and hybrid groups.

, 2016
Phenotypic variance within clusters of inbred and hybrid groups.
Jauhar Ali (232615), Jianlong Xu (841260), Jastin Edrian Revilleza (3207711), Neil Johann Franje (3207705), Xiaoqian Wang (460263), Zhikang Li (416310), Yunlong Pang (841406)   +6 more
core   +1 more source

The Heritability of Mating Behaviour in a Fly and Its Plasticity in Response to the Threat of Sperm Competition [PDF]

, 2014
Phenotypic plasticity is a key mechanism by which animals can cope with rapidly changeable environments, but the evolutionary lability of such plasticity remains unclear.
Price, TA, Bretman, Amanda J., Tom A R Price, Price, Tom A. R., Walling, CA, Anne Lizé, Lizé Anne, Bretman, A, Lizé, A, Bretman Amanda, Amanda Bretman, Bretman, Amanda, Craig A Walling, Price Tom A. R., Lize, Anne, Walling, Craig A., Walling Craig A.   +16 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Mineração da interação genótipo x ambiente em Phaseolus vulgaris L. para o Estado de Santa Catarina Mining of genotype x environment interaction in Phaseolus vulgaris L. to the State of Santa Catarina

Ciência Rural, 2009
Genótipos de feijão (Phaseolus vulgaris L.) dos grupos preto (testados em seis ambientes) e carioca (testados em cinco ambientes) foram avaliados para rendimento de grãos na safra agrícola de 2006/07, no Estado de Santa Catarina.
Jefferson Luís Meirelles Coimbra, Juliano Garcia Bertoldo, Haroldo Tavares Elias, Silmar Hemp, Naine Martins do Vale, Diego Toaldo, Fabiani da Rocha, Leiri Daine Barili, Soraya Helena Garcia, Altamir Frederico Guidolin, Mauricio Marini Kopp   +10 more
doaj  

Prediction of Means and Variances of Crosses With Genome-Wide Marker Effects in Barley

Frontiers in Plant Science, 2018
Background: The expected genetic variance is an important criterion for the selection of crossing partners which will produce superior combinations of genotypes in their progeny.
Tanja Osthushenrich, Matthias Frisch, Carola Zenke-Philippi, Heidi Jaiser, Monika Spiller, László Cselényi, Kerstin Krumnacker, Susanna Boxberger, Doris Kopahnke, Antje Habekuß, Frank Ordon, Eva Herzog   +11 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Genetic variation and quantitative trait loci associated with developmental stability and the environmental correlation between traits in maize

, 2008
There is limited experimental information about the genetic basis of micro-environmental variance (V-E) (developmental stability) and environmental correlations.
Hill, William G., Malvar Pintos, Rosa Ana, Ordas, Bernardo, Ordás López, Bernardo, Malvar, Rosa A.   +4 more
core   +1 more source

Assessment of morphological and chlorophyll content traits in Bambara groundnut (Vigna subterannea [verdc L.])

Journal of Underutilised Crops Research
Background: Bambara groundnut has promising economic potential due to its various uses such as food, medicinal and agronomic benefits. To date, there are no significant breeding efforts aimed at cultivar development and the crop remains underutilised ...
Sinenhlahla E. Xulu, Abe S. Gerrano, Sydney Mavengahama   +2 more
doaj   +1 more source