Results 111 to 120 of about 188,733 (294)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Estimation of Genetic Parameters of Pinus wallichiana Seedlings in the Nursery
International Journal of Bio-Resource and Stress Management, 2022 The present study was carried out at the Department of Silviculture and Agroforestry forest nursery, Dr. Y.S. Parmar UHF, Nauni, Solan, HP, India to estimate genetic parameters on seed germination and growth characters of Pinus wallichiana seedlings ...
Amanpreet Kaur +3 more
doaj
Race in the phenotype of the glaucoma; a genotypic or an environmental variance?
Medical hypothesis, discovery & innovation in optometry, 2022 Letter to the ...
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Phenotypic variance of black oat growing in crop seasons reveals genetic effects predominance
, 2019 : This work aimed to determine variance components and genetic parameters, as well as phenotypic, genetic and environmental correlations among black oat (Avena strigosa) families grown in different crop season.
DANIELA MEIRA (7425323) +8 more
core +1 more source
Extensive impact of low-frequency variants on the phenotypic landscape at population-scale
eLife, 2019 Genome-wide association studies (GWAS) allow to dissect complex traits and map genetic variants, which often explain relatively little of the heritability. One potential reason is the preponderance of undetected low-frequency variants.
Téo Fournier +5 more
doaj +1 more source
COVID-19-Associated Fulminant Myocarditis: Pathophysiology-Related Phenotypic Variance. [PDF]
J Am Coll Cardiol, 2022 Nair A, Deswal A.
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Summary statistics for phenotypic data used to estimate variance components in Hanwoo cattle.
, 2019 Summary statistics for phenotypic data used to estimate variance components in Hanwoo cattle.
Hossein Mehrban (3642013) +4 more
core +1 more source