Results 131 to 140 of about 188,733 (294)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Data from: Artificial selection to increase the phenotypic variance in gmax fails

, 2017
Stabilizing selection is important in evolutionary theories of the maintenance of genetic variance, and has been invoked as the key process determining macro-evolutionary patterns of trait evolution.
Sztepanacz, Jacqueline L., Blows, Mark W.   +1 more
core   +1 more source

Full decomposition of phenotypic variance in dichotomous traits: New methods and key implications for behaviour, demography and evolutionary ecology

Methods in Ecology and Evolution
Numerous traits that define behaviour, development, life‐history and species ecology are expressed as dichotomous alternative phenotypes (e.g. morphological and behavioural polyphenisms, reproductive vs. non‐reproductive states, movement vs. philopatry).
Paul Acker, Jane M. Reid
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

ANOVA results, variance components, and broad sense heritability estimates for phenotypic traits observed in RIL populations.

, 2016
ANOVA results, variance components, and broad sense heritability estimates for phenotypic traits observed in RIL populations.
Iwona Szarejko (3167214), Damian Józefczyk (3167181), Krzysztof Mikołajczak (3167199), Kornelia Gudyś (3167187), Karolina Krystkowiak (3167202), Andrzej Kędziora (3167193), Andrzej Górny (3167217), Maria Surma (3167208), Paweł Krajewski (217712), Justyna Guzy-Wróbelska (3167205), Grzegorz Karg (674922), Joanna Andrusiak (3167184), Aneta Sawikowska (3167196), Janusz Jankowiak (3167211), Piotr Ogrodowicz (3167226), Tadeusz Adamski (3167220), Anetta Kuczyńska (3167190), Wojciech Frohmberg (3167223)   +17 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Adjusted phenotypic means and proportions of the mean phenotypic variance explained by the SNP markers (), for the six popcorn traits evaluated in ENV1 and ENV2.

, 2019
Adjusted phenotypic means and proportions of the mean phenotypic variance explained by the SNP markers (), for the six popcorn traits evaluated in ENV1 and ENV2.
Samuel Henrique Kamphorst (6707624), Carlos Maldonado (5527520), Antônio Teixeira do Amaral Júnior (4829169), Freddy Mora (3713212), Guilherme Ferreira Pena (4704460), Gabrielle Sousa Mafra (5886968), Juliana Saltires Santos (6876572), Rosimeire Barbosa Bispo (6876581), Ismael Albino Schwantes (5912111), Janeo Eustáquio de Almeida Filho (3289821), Pedro Henrique Araújo Diniz Santos (6045197), Fabio Tomaz de Oliveira (6876575), Valter Jario de Lima (6707618), Talles de Oliveira Santos (6876578), Yure Pequeno de Souza (5528543), Marcelo Vivas (4704454)   +15 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Allelic effect of selected marker-trait associations (MTAs) with ≥20% phenotypic variance for 15 traits.

, 2014
Allelic effect of selected marker-trait associations (MTAs) with ≥20% phenotypic variance for 15 traits.
Rajeev K. Varshney (151116), Xuanqiang Liang (42087), Hongjie Li (82868), M. V. C. Gowda (619043), Shivali Sharma (619044), Pawan Khera (619047), Emmanuel Monyo (619051), Aamir W. Khan (619049), Vincent Vadez (619039), Manish K. Pandey (151068), Baozhu Guo (42084), Manda Sriswathi (619041), M. S. Sheshshayee (619040), Abhishek Rathore (560197), Hari D. Upadhyaya (118396), Sube Singh (619050), Mansee Govil (619042), Ganapati Mukri (619054), Scott A. Jackson (123805), Ashish Kumar (152984), Falalou Hamidou (619045), V. Anil Kumar (619046), Ramesh S. Bhat (619048), H. L. Nadaf (619052)   +23 more
core   +1 more source