Results 61 to 70 of about 205,158 (302)

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength [PDF]

, 2012
Osteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput multi-parameter phenotype screen to identify functionally significant skeletal phenotypes in mice ...
Gogakos Apostolos, Campbell, MJ, Anne H. van der Spek (145990), Campbell Michael J., Gogakos, A, Sunter, D, Williams, GR, David Sunter, Bassett, JHD, Boyde, A, Michael J. Campbell (5833), Sunter, D., Richard M Jacques, Project, S.M.G., Alan Boyde (146008), Croucher Peter I., Ramirez-Solis, R, Williams, G.R., Richard M. Jacques (145985), van der Spek Anne H., Holly Evans (145980), Bassett, J.H.D., Ryder, E, Edward Ryder (145998), Peter I. Croucher (146016), Graham R Williams, Evans, H, Bassett J. H. Duncan, Jacques, RM, Anne H van der Spek, J. H. Duncan Bassett (145971), Croucher, PI, Peter I Croucher, Project, SMG, Ryder, E., David Sunter (146002), Holly Evans, Gogakos, A., Jacqueline K. White (119191), Apostolos Gogakos (145975), Ramirez-Solis, R., Jacqueline K White, White Jacqueline K., Boyde, A., van der Spek, A.H., Evans, H., Michael J Campbell, Ramirez-Solis Ramiro, White, J.K., Jacques, R.M., J H Duncan Bassett, Apostolos Gogakos, Jacques Richard M., Croucher, P.I., Ryder Edward, Graham R. Williams (20148), Campbell, M.J., Evans Holly, Ramiro Ramirez-Solis (119181), Williams Graham R., Ramiro Ramirez-Solis, Edward Ryder, Alan Boyde, van der Spek, AH, Sanger Mouse Genetics Project, Sunter David, White, JK, Boyde Alan   +67 more
core   +1 more source

A phlorotannin constituent of Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice

Pharmaceutical Biology, 2017
Context: 2,7″-Phloroglucinol-6,6′-bieckol is a type of phlorotannin isolated from brown algae, Ecklonia cava Kjellman (Phaeophyceae; Laminareaceae). 2,7″-Phloroglucinol-6,6′-bieckol mediates antioxidant activities.
Hyun-Ah Lee, Ji-Hyeok Lee, Ji-Sook Han
doaj   +1 more source

Gene Expression Analysis in Cold Stress Conditions Reveals BBX20 and CLO as Potential Biomarkers for Cold Tolerance in Almond

Horticulturae, 2021
Late spring frosts can become one of the limiting factors for the expansion of cultivation area towards a harsher climate for the almond [Prunus amygdalus Batsch syn P. dulcis (Mill.) D.A.
Beatriz Bielsa, Jorge Israel Ávila-Alonso, Ángel Fernández i Martí, Jérôme Grimplet, María José Rubio-Cabetas   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effect of Time of Day and Sky Conditions on Different Vegetation Indices Calculated from Active and Passive Sensors and Images Taken from UAV

Remote Sensing, 2021
Optical sensors have been widely reported to be useful tools to assess biomass, nutrition, and water status in several crops. However, the use of these sensors could be affected by the time of day and sky conditions.
Romina de Souza, Claudia Buchhart, Kurt Heil, Jürgen Plass, Francisco M. Padilla, Urs Schmidhalter   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

"In-vivo" phenotyping of CYP3A using midazolam as probe drug : development of novel approaches based on highly sensitive LC-MS/MS methods [PDF]

, 2011
Cytochrome P450 (CYP) 3A is the most important subfamily of drug-metabolizing enzymes in humans, responsible for metabolizing more than 50% of the currently marketed drugs.
Link, Bettina
core   +1 more source

Drone based phenotyping for rice [PDF]

, 2022
Training materials including classroom and hands-on field exercises for drone phenotyping were developed and delivered to multiple global partners. Drone-phenotyping was implemented across multiple sites and years on Reference and Antenna panels).
CGIAR Research Program on Rice
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation

Molecular Metabolism, 2019
Objective: The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC). Previous work showed endogenous glucose production is reduced in GNMT-null mice with gluconeogenic precursors ...
Curtis C. Hughey, Freyja D. James, Zhizhang Wang, Mickael Goelzer, David H. Wasserman   +4 more
doaj   +1 more source