Results 11 to 20 of about 174,345 (147)
cd1 Mutation in Drosophila Affects Phenoxazinone Synthase Catalytic Site and Impairs Long-Term Memory. [PDF]
Int J Mol Sci, 2022 Being involved in development of Huntington’s, Parkinson’s and Alzheimer’s diseases, kynurenine pathway (KP) of tryptophan metabolism plays a significant role in modulation of neuropathology. Accumulation of a prooxidant 3-hydroxykynurenine (3-HOK) leads to oxidative stress and neuronal cell apoptosis. Drosophila mutant cardinal (cd1) with 3-HOK excess
Zhuravlev AV +5 more
europepmc +4 more sources
Phenoxazinone synthase from Streptomyces antibioticus: Purification of the large and small enzyme forms [PDF]
Archives of Biochemistry and Biophysics, 1981 Abstract Phenoxazinone synthase has been purified approximately 80-fold from 48-h-old cells of Streptomyces antibioticus. The purification procedure involves streptomycin sulfate and ammonium sulfate precipitations, affinity and Bio-Gel chromatography, and glycerol gradient centrifugation.
Choy, Henry A., Jones, George H.
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Molecular cloning and in vitro expression of a silent phenoxazinone synthase gene from Streptomyces lividans [PDF]
Gene, 1989 Phenoxazinone synthase (PHS) catalyzes a step in actinomycin D biosynthesis in Streptomyces antibioticus. Two sequences from Streptomyces lividans that hybridize to the phs gene of S. antibioticus have been cloned in Escherichia coli K-12 using the plasmid pBR322.
Madu, Anthony C., Jones, George H.
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Two mononuclear cobalt(III) complexes exhibiting phenoxazinone synthase activity
Applied Organometallic Chemistry, 2018 Two mononuclear cobalt(III) complexes, namely [LCo(tmtp)(H2O)]ClO4⋅MeOH (1) (tmtp = tri(m‐tolyl)phosphine) and [LCo(PPh3)(H2O)]PF6 (2), have been prepared from a polydentate ligand, N,N′‐bis(3‐methoxysalicylidehydene)cyclohexane‐1,2‐diamine (H2L). Standard analytical techniques such as elemental analysis and UV–visible and Fourier transform infrared ...
Mamata Mahato +2 more
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Synthesis of highly crystalline LaFeO3 nanospheres for phenoxazinone synthase mimicking activity. [PDF]
RSC Adv, 2021 LaFeO 3 nanospheres were synthesized by a facile sol–gel autocombustion method and explored for the photocatalytic transformation of o -aminophenol to 2-aminophenoxazine-3-one.
Khairy M, Mahmoud AH, Khalil KMS.
europepmc +4 more sources
Preparation and characterization of a highly stable phenoxazinone synthase nanogel. [PDF]
Chem Cent J, 2016 Phenoxazinone synthase (PHS) is a laccase-like multicopper oxidase originating from Streptomyces with great industrial application potential. In this paper, we prepared the PHS nanogel retaining 82 % of its initial activity by aqueous in situ polymerization at pH 9.3.The average diameter of the PHS nanogel was 50.8 nm based on dynamic light scattering (
Jia H +6 more
europepmc +4 more sources
Regulation of phenoxazinone synthase expression in Streptomyces antibioticus. [PDF]
J Bacteriol, 1985 The cloned gene for the subunit of phenoxazinone synthase (PHS), an enzyme implicated in the biosynthesis of actinomycin in Streptomyces antibioticus, was used as a probe to study the regulation of the enzyme. The direction of transcription of the PHS gene was determined with end-labeled restriction fragments derived from the gene.
Jones GH.
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Actinomycin production persists in a strain of Streptomyces antibioticus lacking phenoxazinone synthase. [PDF]
Antimicrob Agents Chemother, 2000 ABSTRACT Truncated fragments of the phenoxazinone synthase gene, phsA , were prepared by the PCR. The resulting fragments were cloned into conjugative plasmid pKC1132 and transferred to Streptomyces antibioticus by conjugation from Escherichia coli .
Jones GH.
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Structure and Function of Phenoxazinone Synthase.
, 1982 Streptomyces antibioticus is a gram positive actinomycete which elaborates actinomycin, a chromopeptide antibiotic, as a secondary metabolite. Phenoxazinone synthase is a key enzyme involved in the biosynthesis of actinomycin.
Johnson, Marcia Elaine
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Pseudomonas as Versatile Aromatics Cell Factory
Biotechnology Journal, Volume 15, Issue 11, November 2020., 2020 This review highlights strategies and achievements regarding the microbial production of aromatics and derivatives from renewable substrates using Pseudomonas as whole‐cell biocatalyst. This includes the de novo biosynthesis and biotransformation of aromatics to other valuable chemicals.
Tobias Schwanemann +3 more
wiley +1 more source