Results 51 to 60 of about 55,307 (220)

Harnessing Toluene Solvent as a Reactant: Regioselective Benzyl Radical Addition to Multi‐π 1,5‐Enynes in a Copper‐Catalyzed Cascade to Indenes

Chemistry – A European Journal, EarlyView.
A copper‐catalyzed three‐component radical cascade of 1,5‐enynes with toluene and benzoic acids enables regioselective benzyl radical addition to multi‐Π systems, efficiently delivering polysubstituted indenes from an abundant solvent feedstock. ABSTRACT C─H activation of toluene generates a benzyl radical that undergoes C─C coupling, converting an ...
Saideh Rajai‐Daryasarei, Fatemeh Chahardehi, Mohammad Mahdi Sharifani, Morteza Jamshidi, Robert Stranger, Frank Rominger, Alireza Ariafard, Saeed Balalaie   +7 more
wiley   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.

PLoS ONE, 2011
During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between uremic toxins and two important efflux pumps, viz. multidrug resistance protein 4 (MRP4) and breast
Henricus A M Mutsaers, Lambertus P van den Heuvel, Lauke H J Ringens, Anita C A Dankers, Frans G M Russel, Jack F M Wetzels, Joost G Hoenderop, Rosalinde Masereeuw   +7 more
doaj   +1 more source

Moderate intake of red wine promotes a significant increase of phenolic metabolites in human faeces [PDF]

, 2015
With the final aim of ascertaining consistent data about the changes of phenolic metabolites in faeces after a regular wine consumption, the present paper compiles the data from two previous human intervention studies: a) a pilot study (n = 8), that ...
Bartolomé, Begoña, Jiménez-Girón, Ana, Martín-Álvarez, Pedro J., Moreno-Arribas, M. Victoria, Muñoz-González, Irene   +4 more
core   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Nutritional and Phytochemical Content of High-Protein Crops [PDF]

, 2016
The authors acknowledge support from the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS) via their strategic research and partnership programs.Peer ...
Cantlay, Louise, Duncan, Gary, Multari, Salvatore, Neacsu, Madalina, Russell, Wendy R., Scobbie, Lorraine, Stewart, Derek, Vaughan, Nicholas   +7 more
core   +2 more sources

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source

The temperature dependence of the retention index for n-alkyl esters of acetic, propionic, cyclohexanecarboxylic, benzoic and phenylacetic acid on DB-1 and DB-5 capillary columns [PDF]

Journal of the Serbian Chemical Society, 2006
The temperature dependence of the retention index was studied for n-alkyl esters of acetic, propionic, cyclohexanecarboxylic, benzoic and phenylacetic acid on DB-1 and DB-5 capillary columns.
DUSAN Z. MIJIN, DUSAN G. ANTONOVIC
doaj   +3 more sources

The Microbiome–Metabolome Response in the Colon of Piglets Under the Status of Weaning Stress

Frontiers in Microbiology, 2020
Weaning is stressful for piglets involving nutritional, physiological, and psychological challenges, leading to an increase in the secretion of cortisol, changes in gut microbiome and metabolites, whereas the underlying relationships remain unclear.
Xueyuan Jiang, Naisheng Lu, Haichao Zhao, Haichao Zhao, Hao Yuan, Dong Xia, Hulong Lei   +6 more
doaj   +1 more source

In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability [PDF]

, 2010
Dietary polyphenols in tea and wine have been associated with beneficial health effects. After ingestion, most polyphenols are metabolized by the colonic microbiota.
Gross, Gabriele, Jacobs, Doris M, Peters, Sonja, Possemiers, Sam, Van de Wiele, Tom, van Duynhoven, John, Vaughan, Elaine E   +6 more
core   +1 more source