Results 181 to 190 of about 394,077 (382)
Studies on Amino-Acids and Related Compounds. XII. Electrolysis of Phenylalanine and its Derivatives in Nitric Acid [PDF]
, 1942 Yoshitaro Takayama +2 more
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Advanced Science, EarlyView.A self‐developed CTC sorting and capture platform enabled single‐cell metabolomics of patient/animal CTCs, revealing brain/bone metastasis‐specific metabolic signatures. A classification model developed from these signatures predicted lung cancer metastasis risk, outperforming traditional markers and total CTC counts (AUCs:89 brain = 0.74; bone = 0.92).
Yang Xu +14 more
wiley +1 more source
Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities
Advanced Science, EarlyView.The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley +1 more source
Phenylalanine and Threonine Levels for Young Chicks
, 1958 B.A. Krautmann +3 more
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Structural Basis of GABAB Receptor Activation during Evolution
Advanced Science, EarlyView.This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou +14 more
wiley +1 more source
A NEW COFACTOR REQUIRED FOR THE ENZYMATIC CONVERSION OF PHENYLALANINE TO TYROSINE
, 1958 Seymour Kaufman
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Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi
Advanced Science, EarlyView.The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda +12 more
wiley +1 more source
THE CONVERSION OF PHENYLALANINE TO TYROSINE IN NORMAL RATS
, 1940 Angela R. Moss, Rudolf Schoenheimer
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Advanced Science, EarlyView.Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou +16 more
wiley +1 more source
THE HYDROXYLATION OF PHENYLALANINE AND ANTIPYRINE IN PHENYLPYRUVIC OLIGOPHRENIA
, 1953 Sidney Udenfriend, Samuel P. Bessman
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