Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase. [PDF]
Int J Mol Sci, 2022 Conde-Giménez M +10 more
europepmc +1 more source
Charakterisierung eines Mausmodells zur BH4-sensitiven Phenylketonurie [PDF]
, 2019 Phenylketonurie (PKU) ist eine angeborene Störung des Aminosäurestoffwechsels, die unbehandelt zu schweren neurologischen Schäden führt. In vielen Fällen ist die einzige mögliche Behandlungsoption eine streng eiweißarme Diät. Im Rahmen klinischer Studien
Eichinger, Anna
core
Optical Coherence Tomography to Assess Neurodegeneration in Phenylalanine Hydroxylase Deficiency. [PDF]
Front Neurol, 2021 Lotz-Havla AS +8 more
europepmc +1 more source
New insights into the structure and function of human phenylalanine hydroxylase : interallelic complementation, protein misfolding and mechanism of catalytic activation [PDF]
, 2011 Tese de doutoramento, Farmácia (Bioquímica), Universidade de Lisboa, Faculdade de Farmácia, 2011Phenylketonuria (PKU) is an autosomal recessive human inborn error of metabolism caused by dysfunction of the liver homotetrameric/homodimeric enzyme ...
Leandro, João Paulo Travassos, 1981-
core
Impact of Fluorinated Ionic Liquids on Human Phenylalanine Hydroxylase-A Potential Drug Delivery System. [PDF]
Nanomaterials (Basel), 2022 Alves MMS +4 more
europepmc +1 more source
Phenylalanine Hydroxylase of Macaca irus [PDF]
, 1975 Richard G.H. Cotton, Phillip J. GRATTAN
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Birth prevalence of phenylalanine hydroxylase deficiency: a systematic literature review and meta-analysis. [PDF]
Orphanet J Rare Dis, 2021 Foreman PK +7 more
europepmc +1 more source
Solvent Sensitivity of Protein Unfolding: Study of Chicken Villin Headpiece Subdomain in Water-Ethanol and Water-DMSO Mixtures [PDF]
arXiv, 2013 In the present work we study and compare unfolding of a small protein, chicken villin headpiece (HP-36) in two different aqueous binary mixtures, namely water-ethanol (EtOH) and water-dimethyl sulphoxide (DMSO). In both the binary mixtures, HP-36 is found to unfold (fully or partially, depending on the mixture) under ambient conditions, that otherwise ...
arxiv
Different Phenotypes for Phenylalanine Hydroxylase Deficiency [PDF]
, 1977 F. Güttler, Gert H. Hansen
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Unravelling the Complex Denaturant and Thermal-Induced Unfolding Equilibria of Human Phenylalanine Hydroxylase. [PDF]
Int J Mol Sci, 2021 Conde-Giménez M, Sancho J.
europepmc +1 more source