Results 81 to 90 of about 23,946 (202)

From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Lignin serves as both a physical and chemical executor of broad‐spectrum plant immunity. This review systematically summarizes classical and recent advances in lignin‐mediated immunity, outlines the multifaceted regulatory modules controlling lignification under biotic stress, discusses key physiological and biochemical mechanisms behind lignin‐based ...
Yanwen Yu, Ke Wang, Huachuan Tuo, Jiankun Li, Liping Xu, Chang‐Jun Liu, Mingyue Gou   +6 more
wiley   +1 more source

Plastic Diets Drive Microbiome and Metabolic Reprogramming in Wax Moth Larvae (Achroia grisella)

Archives of Insect Biochemistry and Physiology, Volume 122, Issue 3, July 2026.
Wax moth larvae (Achroia grisella) can consume LDPE and PLA, triggering polymer‐specific restructuring of the gut microbiome and host metabolism. LDPE feeding enriches Bacillus spp. and is associated with shifts in carbohydrate and amino‐acid pathways consistent with hydrocarbon processing, whereas PLA feeding enriches Enterococcus spp.
Rohan Shah, Anna Marcora, Angela Ruffell, Georgia M. Sinclair, Inka Vanwonterghem, Andrew Bissett, Andrew Hulthen, Gene Wijffels, Cate Paull, David J. Beale   +9 more
wiley   +1 more source

Systematic literature review of the somatic comorbidities experienced by adults with phenylketonuria

Orphanet Journal of Rare Diseases
Background Phenylketonuria (PKU) is an inborn error of phenylalanine (Phe) metabolism that, if untreated, causes Phe accumulation in the brain leading to neurophysiologic alterations and poor outcomes.
Kaleigh B. Whitehall, Sarah Rose, Gillian E. Clague, Kirsten K. Ahring, Deborah A. Bilder, Cary O. Harding, Álvaro Hermida, Anita Inwood, Nicola Longo, François Maillot, Ania C. Muntau, André L. S. Pessoa, Júlio C. Rocha, Fran Rohr, Serap Sivri, Jack Said, Sheun Oshinbolu, Gillian C. Sibbring   +17 more
doaj   +1 more source

Multi‐Induction Strategies in Crops: Mechanisms, Synergistic Effects, and Sustainable Applications for Enhanced Secondary Metabolite Production

Food Frontiers, Volume 7, Issue 4, July 2026.
This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun, Daoyan Xiao, Xingyue Li, Zhaofei Wang, Maoqin Xia, Chao Song, Hong‐Lei Li   +6 more
wiley   +1 more source

Characterization of phenylalanine hydroxylase gene variants and analysis of genotype-phenotype correlation in patients with phenylalanine hydroxylase deficiency from Fujian Province, Southeastern China. [PDF]

Mol Biol Rep, 2022
Zhou J, Zeng Y, Qiu X, Lin Q, Chen W, Luo J, Xu L.   +6 more
europepmc   +1 more source

Neuroprotective Effects of Biosynthetic d‐Calcium Pantothenate and Cyanocobalamin Against MPTP‐Induced Parkinsonism via Microbiota Modulation, Metabolic Homeostasis Restoration, and Endoplasmic Reticulum Stress Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Biosynthetic D‐calcium pantothenate and cyanocobalamin alleviate MPTP‐induced Parkinsonism in mice by modulating gut microbiota, restoring metabolic homeostasis, and inhibiting Endoplasmic Reticulum Stress. ABSTRACT Vitamin B5 (VB5) and Vitamin B12 (VB12) are essential micronutrients widely distributed in functional foods, yet their neuroprotective ...
Yaru Chen, Shaohui Zhu, Yajie Ruan, Kaiqi Zheng, Jing Wang, Qianqian Guan, Tao Xiong   +6 more
wiley   +1 more source

Conventional Phenylketonuria Treatment

Journal of Inborn Errors of Metabolism and Screening, 2016
Phenylketonuria (PKU) is caused by a deficient activity of enzyme phenylalanine (Phe) hydroxylase, which results in high Phe blood concentration, which is toxic to the central nervous system.
Guillén-López Sara MS, RD, López-Mejía Lizbeth Alejandra RD, Ibarra-González Isabel MS, Vela-Amieva Marcela MD   +3 more
doaj   +1 more source

The spectrum of phenylalanine hydroxylase variants and genotype-phenotype correlation in phenylketonuria patients in Gansu, China. [PDF]

Hum Genomics, 2023
Zhang C, Zhang P, Yan Y, Zhou B, Wang Y, Tian X, Hao S, Ma P, Zheng L, Zhang Q, Hui L, Wang Y, Cao Z, Ma X.   +13 more
europepmc   +1 more source

Elucidating the Molecular Mechanisms Underlying Fruit Bag‐Mediated Light Transmittance and Its Effects on Anthocyanin Biosynthesis in Chinese Plum (Prunus salicina ‘Longzhong’): An Integrated Transcriptomic and Metabolomic Analysis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Zuili plum fruits under CK and four bagging treatments (T1–T4) were analyzed via transcriptome and metabolome. The gradient fruit color phenotypes demonstrate that higher light transmittance facilitates anthocyanin accumulation in plum peel. ABSTRACT Anthocyanins exert strong free radical scavenging effects to mitigate cellular oxidative damage, while ...
Yanbiao Li, Jiangong Wang, Zhongxing Zhang, Yanlong Gao, Yang Liu, Qihua Lu, Jun Li   +6 more
wiley   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source