Results 61 to 70 of about 109,987 (177)

Mapping the functional landscape of frequent phenylalanine hydroxylase (PAH) genotypes promotes personalised medicine in phenylketonuria [PDF]

, 2015
Background: In phenylketonuria, genetic heterogeneity, frequent compound heterozygosity, and the lack of functional data for phenylalanine hydroxylase genotypes hamper reliable phenotype prediction and individualised treatment.
Woidy, Mathias, Zschocke, Johannes, Muntau, Ania C, Muntau, Ania C., Feillet, Francois, Danecka, Marta K., Gersting, Søren W., Danecka, Marta, Gersting, Søren W   +8 more
core   +1 more source

Phenylalanine–tyrosine–catecholamine axis disorders: pathways, molecular diagnosis, therapeutics, and emerging translational monitoring technologies

Frontiers in Molecular Biosciences
Disorders of the phenylalanine–tyrosine–catecholamine axis are a clinically relevant group of neurometabolic conditions in which pathogenic variants in key enzymes impair dopamine and norepinephrine biosynthesis.
Martina Isabella Armas Samaniego, Martina Isabella Armas Samaniego, Benjamin Arias-Almeida, Andrés León-Piñeiros, Jorge G. Figueroa, Andrea Vargas-Freire, Melissa López, Natalí Solano-Cueva, Juan Carlos Collantes, María de Lourdes Huiracocha-Tutiven, Gabriele Davide Bigoni-Ordóñez, Juan Carlos Pozo-Palacios, Vanessa Romero   +12 more
doaj   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, Volume 293, Issue 20, Page 6022-6037, October 2026.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

Partial purification of phenylalanine hydroxylase from dog liver

, 1975
Phenylalanine hydroxylase from dog liver was purified ten fold. The physical and kinetic properties of phenylalanine hydroxylase from dog liver in many respects closely resemble physical and kinetic properties of the same enzyme from other organism ...
Ross, Peggy L. Horner
core  

Identification of Phenylalanine 3-Hydroxylase for meta-Tyrosine Biosynthesis

, 2016
Phenylalanine hydroxylase (PheH) is an iron(II)-dependent enzyme that catalyzes the hydroxylation of aromatic amino acid l-phenylalanine (l-Phe) to l-tyrosine (l-Tyr).
Wenjun Zhang (685002), Brian D. Ames (2187694), Christopher T. Walsh (1265718)   +2 more
core   +1 more source

Multi‐Omics Analysis Uncovers the Salicylic Acid and Ethylene‐Responsive Transcription Factor‐Mediated Defence Mechanism of Panax notoginseng to Panax notoginseng Virus Y

Molecular Plant Pathology, Volume 27, Issue 10, October 2026.
Salicylic acid (SA) enhances the resistance of Panax notoginseng to Panax notoginseng virus Y (PnVY) by elevating endogenous SA levels, alleviating photosynthetic suppression and maintaining cellular redox homeostasis through the activation of glutathione metabolism.
Wenyun Li, Zhongchao He, Yuan Qu, Diqiu Liu   +3 more
wiley   +1 more source

Domestication‐associated reduction of methyl salicylate in tomato root and its significance for resistance to root‐knot nematode

New Phytologist, Volume 252, Issue 1, Page 414-426, October 2026.
Root volatile profiling reveals domestication‐associated variation in methyl salicylate (MeSA) accumulation in tomato. Summary Methyl salicylate (MeSA) plays diverse roles in the aerial parts of plants. By contrast, its biosynthesis and function in roots remain poorly understood.
Weijiao Wang, Manoj Sapkota, Sobhan Bahrami Zadegan, Tarek Hewezi, Esther van der Knaap, Feng Chen   +5 more
wiley   +1 more source

A TAF10‐ERF109 Transcriptional Module Directs Flavonoid‐Based Stress Resilience and Yield Enhancement in Foxtail Millet and Wheat

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5352-5368, October 2026.
ABSTRACT To ensure sustainable agricultural production under escalating environmental constraints such as drought and salinity, innovative strategies are urgently needed. Here, we reveal in foxtail millet (Setaria italica) that transcription factors TAF10 and ERF109 form a functional complex which co‐activates the expression of key flavonoid ...
Meng Zhang, Kangwei Wang, Jiayin Fan, Yue Zheng, Qi Zhang, Haoyang Du, Shenghui Xiao, Jinguang Huang, Kang Yan, Shizhong Zhang, Qiang He, Guanqing Jia, Chengchao Zheng, Xianmin Diao, Guodong Yang, Changai Wu   +15 more
wiley   +1 more source

Decrease of phenylalanine hydroxylase during hepatocyte proliferation

, 1982
In partially hepatectomized rats, the activity of phenylalanine hydroxylase decreased in the regenerating liver but not in the kidney. The concentration of corticosterone in the plasma of hepatectomized rats increased, and phenylalanine hydroxylase ...
Ramasarma, T, Manjunath, R, Shivaswamy, Vidya   +2 more
core  

The two molecular weight forms of rat phenylalanine hydroxylase are encoded by different messenger RNAs

, 1983
The two molecular weight forms of rat phenylalanine hydroxylase are encoded by different messenger ...
Julian Mercer (13076475), SM Hunt (14570279), RGH Cotton (14574842)   +2 more
core   +1 more source