Dictyostelium phenylalanine hydroxylase is activated by its substrate phenylalanine [PDF]
dicPAH and dicPAH bind by molecular sieving (View Interaction: 1, 2, 3, 4)
Soo-Woong Lee+7 more
openaire +3 more sources
Preparation of Nuclear Spin Singlet States using Spin-Lock Induced Crossing [PDF]
We introduce a broadly applicable technique to create nuclear spin singlet states in organic molecules and other many-atom systems. We employ a novel pulse sequence to produce a spin-lock induced crossing (SLIC) of the spin singlet and triplet energy levels, which enables triplet/singlet polarization transfer and singlet state preparation.
arxiv +1 more source
Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors [PDF]
The aromatic amino acid hydroxylases (AAAHs) phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylases 1 and 2 are structurally related enzymes that contain an active site iron atom and depend on tetrahydrobiopterin (BH4) as ...
Baumann, Anne+8 more
core +1 more source
In-situ measurements of the radiation stability of amino acids at 15-140 K [PDF]
We present new kinetics data on the radiolytic destruction of amino acids measured in situ with infrared spectroscopy. Samples were irradiated at 15, 100, and 140 K with 0.8-MeV protons, and amino-acid decay was followed at each temperature with and without H$_2$O present.
arxiv +1 more source
The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders [PDF]
INTRODUCTION: Neurotransmitters are chemical messengers that enable communication between the neurons in the synaptic cleft. Inborn errors of neurotransmitter biosynthesis, breakdown and transport are a group of very rare neurometabolic diseases ...
Cortès Saladelafont, Elisenda+16 more
core +1 more source
Molecular analysis of the early interaction between the grapevine flower and Botrytis cinerea reveals that prompt activation of specific host pathways leads to fungus quiescence [PDF]
Grape quality and yield can be impaired by bunch rot, caused by the necrotrophic fungus Botrytis cinerea. Infection often occurs at flowering, and the pathogen stays quiescent until fruit maturity.
Agudelo-Romero+102 more
core +1 more source
Electronic decoherence following photoionization: full quantum-dynamical treatment of the influence of nuclear motion [PDF]
Photoionization using attosecond pulses can lead to the formation of coherent superpositions of the electronic states of the parent ion. However, ultrafast electron ejection triggers not only electronic but also nuclear dynamics---leading to electronic decoherence, which is typically neglected on time scales up to tens of femtoseconds.
arxiv +1 more source
An isotope dilution model for partitioning of phenylalanine and tyrosine uptake by the liver of lactating dairy cows [PDF]
An isotope dilution model to describe the partitioning of phenylalanine (PHE) and tyrosine (TYR) in the bovine liver was developed. The model comprises four intracellular and six extracellular pools and various flows connecting these pools and external ...
A. Bannink+29 more
core +1 more source
Probing Scalar Coupling Differences via Long-Lived Singlet States [PDF]
We probe small scalar coupling differences via the coherent interactions between two nuclear spin singlet states in organic molecules. We show that the spin-lock induced crossing (SLIC) technique enables the coherent transfer of singlet order between one spin pair and another.
arxiv +1 more source
Deciphering the 'fuzzy' interaction of FG nucleoporins and transport factors using SANS [PDF]
The largely intrinsically disordered phenylalanine-glycine-rich nucleoporins (FG Nups) underline a selectivity mechanism, which enables the rapid translocation of transport factors (TFs) through the nuclear pore complexes (NPCs). Conflicting models of NPC transport have assumed that FG Nups undergo different conformational transitions upon interacting ...
arxiv +1 more source