Results 41 to 50 of about 24,432 (224)

Exploring Raman Spectroscopy as a Detection Tool for Cardiovascular Diseases and Diabetes Mellitus in Fingernails

Journal of Raman Spectroscopy, EarlyView.
Endogenous constituents vary between fingernails of healthy, cardiovascular and diabetic participants. Raman spectroscopy yields a biochemical fingerprint of key endogenous constituents and disease‐related biomarkers. Combined with machine learning algorithms, Raman spectroscopy can classify healthy, cardiovascular and diabetic based on their Raman ...
Megan Wilson, Dhiya Al‐Jumeily, Leung Tang, Jason Birkett, Iftikhar Khan, Ismail Abbas, Matthew Harper, Sulaf Assi   +7 more
wiley   +1 more source

Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice

Communications Biology
Serotonin exerts numerous neurological and physiological actions in the brain and in the periphery. It is generated by two different tryptophan hydroxylase enzymes, TPH1 and TPH2, in the periphery and in the brain, respectively, which are members of the ...
Yunqing Cao, Oliver Popp, Niccolo Milani, Fatimunnisa Qadri, Ralf Kühn, Philipp Mertins, Michael Bader, Natalia Alenina   +7 more
doaj   +1 more source

Dictyostelium phenylalanine hydroxylase is activated by its substrate phenylalanine [PDF]

FEBS Letters, 2012
dicPAH and dicPAH bind by molecular sieving (View Interaction: 1, 2, 3, 4)
Kim, Hye-Lim, Park, Mi-Bee, Kim, Yumin, Yang, Yun Gyeong, Lee, Soo-Woong, Zhuang, Ningning, Lee, Kon Ho, Park, Young Shik   +7 more
openaire   +2 more sources

Next‐generation sequencing in newborn screening: Current status, challenges, and future perspectives

Pediatric Investigation, EarlyView.
Newborn screening shifts from biochemical to genetic methods. Global exploration is promising but requires overcoming challenges and international collaboration to optimize implementation. ABSTRACT Newborn screening (NBS) is a key public health intervention that improves children's health outcomes by enabling precise intervention through the early ...
Zhelan Huang, Wenhao Zhou
wiley   +1 more source

Salicylic acid: a key natural foundation for next‐generation plant defense stimulators

Pest Management Science, EarlyView.
Salicylic acid is emerging as a key natural molecule in sustainable crop protection, supporting diverse strategies to stimulate and sustain plant immunity for a greener agricultural future. Abstract The field of crop protection is undergoing a major transition.
Ruth Oussou, Sylvain La Camera, Cécile Marivingt‐Mounir, Jean‐François Chollet   +3 more
wiley   +1 more source

Mutation Analysis of PAH Gene in Phenylketonuria Patients from the North of Iran: Identification of Three Novel Pathogenic Variants

International Journal of Preventive Medicine
Background: There are more than 1100 different pathogenic variants in the phenylalanine hydroxylase (PAH) gene that are responsible for phenylketonuria (PKU) diseases, and the spectrum of these mutations varies in different ethnic groups.
Hossein Jalali, Daniel Zamanfar, Muhammad Amirzadegan, Farshide Ghadami, Mahan Mahdavi, Mohammad Reza Mahdavi   +5 more
doaj   +1 more source

High Protein Diet and Phenylalanine Hydroxylase Activities in Rats

Pteridines, 1989
The effects of a diet of 85% casein on the activities of the phenylalanine hydroxylases of rat liver and kidney have been compared. Whereas only the tetrahydrobiopterin-dependent activity of rat hepatic phenylalanine hydroxylase is significantly ...
Carty Michael P., Beirne Edel, Donlon John   +2 more
doaj   +1 more source

Allosteric regulation of phenylalanine hydroxylase [PDF]

Archives of Biochemistry and Biophysics, 2012
The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin.
openaire   +2 more sources

Root tip excision‐induced exodermis lignification impacts lateral root emergence in Brachypodium distachyon

New Phytologist, EarlyView.
Summary The mechanisms controlling lateral root emergence in monocots, particularly the role of the exodermis, are poorly understood. We investigated how natural variation in the Brachypodium distachyon stress response shapes root system architecture by modulating cell wall dynamics.
Kevin Bellande, Cristovão De Jesus Vieira Teixeira, Marius Malai, Angelina D'Orlando, Léa Perez, Richard Sibout, Anne C. Roulin, Joop E. M. Vermeer, Thomas Badet   +8 more
wiley   +1 more source

A method for phenylalanine self-monitoring using phenylalanine ammonia-lyase and a pre-existing portable ammonia detection system

Molecular Genetics and Metabolism Reports, 2023
Phenylketonuria is an inborn error of phenylalanine metabolism caused by a phenylalanine hydroxylase deficiency. To prevent the occurrence of neurological symptoms and maternal complications resulting from phenylketonuria, patients must adhere to a ...
Yoichi Wada, Eriko Totsune, Yasuko Mikami-Saito, Atsuo Kikuchi, Toshio Miyata, Shigeo Kure   +5 more
doaj   +1 more source