Results 11 to 20 of about 11,024 (202)

Effects of phenylbutazone alone or in combination with a nutritional therapeutic on gastric ulcers, intestinal permeability, and fecal microbiota in horses

Journal of Veterinary Internal Medicine, 2021
Background Gastrointestinal (GI) injury and dysbiosis are adverse events associated with nonsteroidal anti‐inflammatory drug (NSAID) use in horses. Phenylbutazone has been shown to alter GI barrier function both in vitro and ex vivo, but its effects on ...
Canaan M. Whitfield‐Cargile, Michelle C. Coleman, Noah D. Cohen, Ana M. Chamoun‐Emanuelli, Cristobal Navas DeSolis, Taylor Tetrault, Ryan Sowinski, Amanda Bradbery, Mattea Much   +8 more
doaj   +2 more sources

Enhancing the dissolution of phenylbutazone using Syloid® based mesoporous silicas for oral equine applications

Journal of Pharmaceutical Analysis, 2018
Three mesoporous silica excipients (Syloid® silicas AL-1 FP, XDP 3050 and XDP 3150) were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although
Laura J. Waters, John P. Hanrahan, Joseph M. Tobin, Catherine V. Finch, Gareth M.B. Parkes, Shamsuddeen A. Ahmad, Faraj Mohammad, Maria Saleem   +7 more
doaj   +2 more sources

Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism

Molecules, 2019
A drug design for safer phenylbutazone was been explored by reactivity and docking studies involving single electron transfer mechanism, as well as toxicological predictions.
Rosivaldo S. Borges, Ivanete C. Palheta, Sirlene S. B. Ota, Roberto B. Morais, Valéria A. Barros, Ryan S. Ramos, Rai C. Silva, Josivan da S. Costa, Carlos H. T. P. Silva, Joaquín M. Campos, Cleydson B. R. Santos   +10 more
doaj   +2 more sources

Survey describing the perspectives and practices of Australian veterinarians to pain management in horses. [PDF]

Aust Vet J
Objective To describe Australian practices and attitudes regarding equine analgesia. Study Design Cross‐sectional anonymous, voluntary survey of Australian veterinarians treating equine patients. Methods Australian veterinarians in equine or mixed practices completed a six‐section, 60‐question survey between November 2019 to August 2020.
Whitelock A, Goodwin W, Dryburgh L, Mshelbwala PP, Rae L, Marwedel L, Lok T, Kemp K, Stewart AJ.   +8 more
europepmc   +2 more sources

The proteomic differences and expression of fatty acid-binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone. [PDF]

Equine Vet J
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Vinijkumthorn R, Prapaiwan N, Chotikaprakal T, Prompiram P, Phaonakrop N, Roytrakul S, Tesena P.   +6 more
europepmc   +2 more sources

Joint Statement of EFSA and EMA on the presence of residues of phenylbutazone in horse meat [PDF]

EFSA Journal, 2013
Controls in Member States have revealed the presence of phenylbutazone in horse carcasses intended for the food chain.  Following the request from the European Commission, the European Medicines Agency and the European Food Safety Authority jointly ...
European Food Safety Authority
doaj   +1 more source

“Ain’t She a Bute?”: The Importance of Proper History Taking in a Case of Inappropriate Use of Horse NSAID in a Human

Clinics and Practice, 2021
A 41-year-old woman with no significant past medical history presented to the hospital with complaints of nausea, vomiting, and generalized weakness over two weeks.
Khalid Sawalha, Ryan James, Farah Mazahreh, Harmeen Goraya, Fuad Habash   +4 more
doaj   +1 more source

Impact of concurrent treatment with omeprazole on phenylbutazone-induced equine gastric ulcer syndrome (EGUS).

Equine Veterinary Journal, 2020
BACKGROUND Phenylbutazone is commonly prescribed for treatment of various painful or inflammatory disorders in horses, but is associated with gastrointestinal (GI) adverse effects.
M. Ricord, F. Andrews, Francisco J Morales Yñiguez, M. Keowen, F. Garza, L. Paul, A. Chapman, H. Banse   +7 more
semanticscholar   +1 more source

Study of photolysis on the active material Phenylbutazone in veterinarian drug Isophen [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2013
The veterinary medicine isophen was used in this study. Isophen contains phenylbutazone as active material .Numbers of samples of isophen were prepared and were determined absorbance were determined and comparison subjected to radiation for different ...
Hanan H. Flaeh, Wajeeh Y. Mohammed, Authman S. Ibrahim, Sattar S. Ibrahim   +3 more
doaj   +1 more source

Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses

Frontiers in Veterinary Science, 2023
BackgroundPain management is critical to equine welfare with non-steroidal anti-inflammatory drugs (NSAID) commonly used in horses. However, systemic NSAID use is limited by harmful gastrointestinal and renal side effects.
Molly O’Brien, Jonathan P. Mochel, Jonathan P. Mochel, Jonathan P. Mochel, Kevin Kersh, Chong Wang, Chong Wang, Jarrod Troy   +7 more
doaj   +1 more source