Results 81 to 90 of about 17,388 (185)

Synthesis of 6β-N(5)-Methyl-5,6,7,8-tetrahydro-L-biopterin

Pteridines, 1993
Summary 6β-N(5)-methyl-5.6J,8-tetrahydro-L-biopterin·2 HC1. a new derivate of biological interest, was synthesized from 6β-5,6,7,8-tetrahydro-L-biopteril·2 HC1 and characterized.
Bosshard Rene, Heizmann Claus W., Viscontini Max   +2 more
doaj   +1 more source

Pregnancy in phenylketonuria: dietary treatment aimed at normalising maternal plasma phenylalanine concentration. [PDF]

, 1991
Greg Thompson, D. E. M. Francis, Denise M. Kirby, Richard C. Compton   +3 more
openalex   +1 more source

Delivery strategies of messenger RNA therapeutics for brain disorders

Bulletin of the Korean Chemical Society, Volume 46, Issue 12, Page 1186-1204, December 2025.
Thus, mRNA therapeutics offer a powerful new avenue for the treatment of brain diseases. This review examines strategies to bypass biological barriers, particularly the blood–brain barrier, and explores emerging delivery systems, such as direct intracerebral injection, intracerebroventricular injection, systemic delivery (including intravenous ...
Kounghwa Youn, Sunmin Oh, Hyunchae Gil, Yongseok Choi, Gyochang Keum, Eun‐Kyoung Bang   +5 more
wiley   +1 more source

Association of Unemployment and Government Stringency With the Increased Burden of Anxiety and Depression Amid the Public Health Emergency: A Global Perspective

Brain and Behavior, Volume 15, Issue 12, December 2025.
This ecological, country‐level cross‐sectional study found that greater increases in unemployment and higher government stringency were significantly associated with rises in the incidence of anxiety and depressive disorders, particularly among females, younger populations, and countries with higher sociodemographic indices.
Chen Zhao, Xīn Gào, Mengdi Zhang, Weihua Yue, Xiao Zhang   +4 more
wiley   +1 more source

Generation of Pseudo Metabolites as a Side Reaction in On‐Tissue Chemical Derivatization in Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Chemistry–Methods, Volume 5, Issue 12, November 2025.
On‐tissue chemical derivatization reagents enhance sensitivity and specificity, but the impact of side reactions remains understudied. The reactive matrix FMP‐10 promotes Mukaiyama‐like condensation reactions between endogenous metabolites to form pseudo metabolites that are structurally identical to endogenous metabolites.
Tobias Bausbacher, Alessa L. Henneberg, Stephanie Meyer, Stefan Schmidt, Aubry K. Miller, Christiane A. Opitz, Carsten Hopf   +6 more
wiley   +1 more source

Newborn Screening and Treatment of Phenylketonuria: Projected Health Outcomes and Cost-Effectiveness [PDF]

, 2021
Huey-Fen Chen, Angela M. Rose, Susan E. Waisbren, Ayesha Ahmad, Lisa A. Prosser   +4 more
openalex   +1 more source

Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation

iMetaOmics, Volume 2, Issue 4, December 2025.
Microbiota‐gut‐brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood‐brain barrier (BBB), and brain. This integrated platform incorporates neural (blue), endocrine (yellow), immune (pink), and metabolic (green) pathways to investigate the impact ...
Yue Tang, Hewen Chen, Ziyue Zhao, Xuesong Kang, Wenxin Wang, Kun Dai, Yufei Guo, Axin Liang, Aiqin Luo, Zikai Hao   +9 more
wiley   +1 more source

Relationship Between Gut Microbiota and Phenylalanine Levels: A Mendelian Randomization Study

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study showed that Family XIII AD3011 group was associated with reduced Phe levels, providing important evidence to reveal the interaction between gut microbiota and Phe levels, and providing a scientific basis for the development of personalized diet and nutrition recommendations for PKU patients.
Zhijuan Liu, Minggang Ye, Huiya Jin, Weixia Chen, Hasitiyaer Jieens, Rui Han   +5 more
wiley   +1 more source

Delays in Newborn Screening for Phenylketonuria from Birth to Diagnosis and Factors Affecting This

Children
This study aims to evaluate the process of neonatal phenylketonuria (PKU) screening from birth to admission to the pediatric metabolism polyclinic, determining delays in the screening program and the factors influencing them.
Banu Kadıoğlu Yılmaz, Zafer Bağcı
doaj   +1 more source

Protein status of people with phenylketonuria: a scoping review protocol [PDF]

, 2021
Sarah Firman, Radha Ramachandran, Kevin Whelan, Oliver C. Witard, Majella O’Keeffe   +4 more
openalex   +1 more source