Results 51 to 60 of about 18,136 (230)

Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant

open access: yesOxidative Medicine and Cellular Longevity, 2017
Selenium is an essential mineral naturally found in soil, water, and some of the food. As an antioxidant, it is one of the necessary trace elements in human body and has been suggested as a dietary supplement for health benefit.
Ning Wang   +5 more
semanticscholar   +1 more source

The European challenges of funding orphan medicinal products [PDF]

open access: yes, 2018
Funding of orphan medicinal products (OMPs) is an increasing challenge in the European Union (EU).To identify the different methods for public funding of OMPs in order to map the availability for rare disease patients, as well as to compare the public ...
Arickx, Francis   +14 more
core   +4 more sources

Study of Resistive Switching Dynamics and Memory States Equilibria in Analog Filamentary Conductive‐Metal‐Oxide/HfOx ReRAM via Compact Modeling

open access: yesAdvanced Electronic Materials, EarlyView.
A physics‐based compact model for Conductive‐Metal‐Oxide/HfOx ReRAM, accounting for ion dynamics, electronic conduction, and thermal effects, is presented. Accurate and versatile simulations of analog non‐volatile conductance modulation and memory state stabilization enable reliable circuit‐level studies, advancing the optimization of neuromorphic and ...
Matteo Galetta   +9 more
wiley   +1 more source

A Memristive Associative Learning Circuit for Fault‐Tolerant Multi‐Sensor Fusion in Autonomous Vehicles

open access: yesAdvanced Intelligent Systems, EarlyView.
A memristor‐based associative learning circuit is presented for real‐time, fault‐tolerant sensor fusion in autonomous systems. The circuit mimics biological learning to recognize driving scenarios even with missing or degraded sensor inputs. Its low‐power, analog architecture enables robust decision‐making across diverse conditions, offering a ...
Kapil Bhardwaj   +3 more
wiley   +1 more source

Zebrafish: A Versatile and Powerful Model for Biomedical Research

open access: yesBioEssays, EarlyView.
Zebrafish are vital for advancing precision medicine, offering a genetically tractable and optically transparent vertebrate model with strong genetic homology to humans. They enable rapid and cost‐effective disease modeling and drug discovery, accelerating insights into cardiovascular, neurological, metabolic, and oncological disorders through gene ...
Sundus Siddiqui   +3 more
wiley   +1 more source

Preparation of a Selective L-Phenylalanine Imprinted Polymer Implicated in Patients with Phenylketonuria

open access: yesIranian Journal of Medical Sciences, 2014
Background: Molecular imprinting is a method for synthesizing polymers with structure-selective adsorption properties with applications such as, selectivity binding, drug delivery systems and anti-bodies.
Parvaneh Najafizadeh   +3 more
doaj  

Urinary neopterin concentrations vs total neopterins for clinical utility [PDF]

open access: yes, 1989
Fuchs D, Milstien S, Krämer A, et al. Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry. 1989;35(12):2305-2307.Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and ...
Fuchs, Dietmar   +7 more
core   +1 more source

Generation of Pseudo Metabolites as a Side Reaction in On‐Tissue Chemical Derivatization in Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

open access: yesChemistry–Methods, EarlyView.
On‐tissue chemical derivatization reagents enhance sensitivity and specificity, but the impact of side reactions remains understudied. The reactive matrix FMP‐10 promotes Mukaiyama‐like condensation reactions between endogenous metabolites to form pseudo metabolites that are structurally identical to endogenous metabolites.
Tobias Bausbacher   +6 more
wiley   +1 more source

Genetics of Phenylketonuria: Then and Now

open access: yesHuman Mutation, 2016
More than 950 phenylalanine hydroxylase (PAH) gene variants have been identified in people with phenylketonuria (PKU). These vary in their consequences for the residual level of PAH activity, from having little or no effect to abolishing PAH activity ...
N. Blau
semanticscholar   +1 more source

The Adult Phenylketonuria (PKU) Gut Microbiome

open access: yesMicroorganisms, 2021
Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism primarily treated through a phenylalanine-restrictive diet that is frequently supplemented with an amino acid formula to maintain proper nutrition.
Viviana J. Mancilla   +3 more
semanticscholar   +1 more source

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