Results 91 to 100 of about 93,963 (358)

Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs. [PDF]

, 2018
PURPOSE: To evaluate the effects of eslicarbazepine acetate (ESL) on lipid metabolism and to determine whether reduced statin exposure during ESL therapy has clinical consequences. SUBJECTS AND METHODS: We conducted a post-hoc analysis of pooled data for
Ben-Menachem, Elinor, Blum, David, Carreño, Mar, da Silva, Patrício Soares, Gidal, Barry E., Grinnell, Todd, Li, Yan, Mintzer, Scott, Moreira, Joana, Rogin, Joanne B., Schwab, Matthias, Wechsler, Robert T.   +11 more
core   +1 more source

Therapeutic Drug Monitoring and Methods of Quantitation for Carbamazepine [PDF]

, 2017
Carbamazepine is an early anticonvulsant still used today in the treatment of several forms of epilepsy. An active metabolite in the human body contributes to its pharmacological effect.
Ana Vlasceanu, Cristian Balalau, Cristian Tuchila, Cristina Pirvu, Daniela Baconi, Denisa Balalau, Miriana Stan, null null   +7 more
core   +4 more sources

In‐hospital outcomes of lacosamide versus levetiracetam for early adjunctive treatment of status epilepticus: A Nationwide Japanese retrospective cohort study

Epilepsia Open, EarlyView.
Abstract Objective Status epilepticus (SE) is a neurological emergency requiring immediate treatment. Although intravenous lacosamide (LCM) is used for the management of epilepsy, its effectiveness in treating SE remains unclear. We aimed to compare the in‐hospital outcomes between intravenous LCM and levetiracetam (LEV) as an early adjunctive therapy ...
Yumiko Nakamura, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Yuichiro Shirota, Masashi Hamada, Kiyohide Fushimi, Tatsushi Toda, Satoshi Kodama   +8 more
wiley   +1 more source

Phenytoin-induced dyskinesia: a case report

Journal of Medical Case Reports, 2023
Background Dyskinesia is a movement disorder categorized by involuntary movement of muscle. Although dyskinesia can be brought on by taking medications, it can also be a symptom of a variety of diseases.
Kashvi C. Shah, Nishi S. Patel, Paritosh Vasani, Avinash Khadela, Vivek P. Chavda, Lalitkumar Vora   +5 more
doaj   +1 more source

Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea

Epilepsia Open, EarlyView.
Abstract Objective This study evaluated the long‐term risk of major cardiovascular diseases (CVDs) in patients with epilepsy using a nationwide cohort, aiming to address critical gaps in population‐based evidence on brain–heart interactions. Methods Data from the Korean National Health Insurance Service (2002–2013) were analyzed.
Youngoh Bae, Chaeyoon Kang, Yejin Lee, Haerim Cho, Hohyun Jung, Seung Won Lee   +5 more
wiley   +1 more source

Association Between Prophylactic Anti-Seizure Medication and Early Post-Traumatic Seizures: An International Observational Multicenter Study. [PDF]

MedComm (2020)
Multicenter study: Data from 28 Pediatric Intensive Care Units (PICUs) across 15 countries in Asia, Latin America, and Europe. Key findings: – Incidence of EPTS: 23.1% of children with TBI developed early post‐traumatic seizures (EPTS). – Effectiveness of Prophylactic ASM: 9.6% of children who received prophylactic anti‐seizure medication (ASM ...
Ji J, Roa G JD, Chong SL, Wang Q, Gan CS, Ng JPW, Miranda TET, Chamorro FIP, Chan LCN, Abbas Q, Ong JSM, Ardila IJ, Kazzaz YM, Domínguez-Rojas JA, Kurosawa H, Domínguez SBR, Arriola NEG, Watzlawik NZ, Yock-Corrales A, Palomino REL, Aparicio G, Caporal P, Gómez RET, Liu C, Samransamruajkit R, Anantasit N, Turina DM, Flores MF, Lee PC, Pilar-Orive FJ, Dang H, Chor YK, Ming M, Jaramillo-Bustamante JC, González-Dambrauskas S, Lee JH, Qian S.   +36 more
europepmc   +2 more sources

Stiripentol use in Dravet syndrome patients in the USA: Results of a real‐world study

Epilepsia Open, EarlyView.
Abstract Objective Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy with a high seizure burden and mortality risk. Stiripentol, one of the first DS‐specific therapies, received FDA approval in 2018 but its real‐world use and impact post‐approval in the USA remain insufficiently characterized.
Elaine Wirrell, James Wheless, Michael Scott Perry, Linda Laux, Karen C. Keough, Julie Ziobro, Aimee F. Luat, Gewalin Aungaroon, Michael A. Ciliberto, Roxane Noel, Laurent Chancharme, Joseph Sullivan   +11 more
wiley   +1 more source

Bioavailability of intravenous fosphenytoin sodium in healthy Japanese volunteers [PDF]

, 2012
To compare and evaluate the bioavailability for intravenous fosphenytoin sodium with that of intravenous phenytoin sodium in Japanese subjects. In study 1, healthy Japanese male volunteers received a 30-min infusion of 375 mg fosphenytoin sodium or an ...
Kenji Shimizu, Naotaka Usui, Shigeki Shimasaki, Susumu Kobayashi, Tadayuki Hiroki, Yushi Inoue   +5 more
core   +1 more source

Neurodevelopmental features in KCNQ2 developmental and epileptic encephalopathy may have limited associations with KV7.2 dysfunction

Epilepsia Open, EarlyView.
Abstract Objective Variants in KCNQ2 encoding the voltage‐gated potassium channel KV7.2 are associated with developmental and epileptic encephalopathy (DEE) of varying severity. This study examined the relationship of KCNQ2 variant dysfunction with the neurodevelopmental phenotype of individuals with KCNQ2‐DEE. Methods A parent‐reported survey gathered
Jessa S. Bidwell, Carlos G. Vanoye, Reshma R. Desai, Anne T. Berg, Alfred L. George Jr   +4 more
wiley   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources