Results 71 to 80 of about 45,385 (273)

Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/ midazolam on acute, lethal cocaine toxicity

, 2012
Objective: To evaluate the effects of etomidate, ketamine, phenytoin, and phenytoin/midazolam in a mouse model of acute cocaine toxicity. Methods: We performed a randomized controlled study consisting of five groups (n525 each) of rats that received ...
Kortunay, S., Seyit, Murat, Yuksel, A., Erdur, Bülent, Ergin, Ahmet, Degirmenci, Eylem   +5 more
core   +1 more source

New onset refractory status epilepticus (NORSE) versus refractory status epilepticus not meeting NORSE criteria: A comparative clinical and electroencephalography‐based study

Epilepsia, EarlyView.
Abstract Objective New onset refractory status epilepticus (NORSE) is a rare, severe presentation of refractory status epilepticus (RSE), with approximately half of cases cryptogenic NORSE (c‐NORSE). We compared electroencephalographic (EEG) findings alongside clinical features between NORSE and RSE not meeting NORSE criteria to better understand ...
Seren Hawksworth, Nina Moutonnet, Gregory Scott, Sanjeev Rajakulendran, Mahinda Yogarajah, Matthew C. Walker, Umesh Vivekananda   +6 more
wiley   +1 more source

Phenytoin: A Guide to Therapeutic Drug Monitoring

Proceedings of Singapore Healthcare, 2013
Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics.
Melissa Faye Wu BSc (Pharm) (Hons), Wai Hing Lim B.Pharm (Hons), M Clin Pharm   +1 more
doaj   +1 more source

The retinoprotective role of phenytoin

, 2018
Silvia Bartollino,1 Flavia Chiosi,1 Silvio di Staso,2 Maurizio Uva,3 Arduino Pascotto,1 Michele Rinaldi,4 Jan M Keppel Hesselink,5 Ciro Costagliola1 1Eye Clinic, Department of Medicine and Health Sciences “V.
Chiosi F, Pascotto A, Uva M, Bartollino S, Keppel Hesselink JM, di Staso S, Rinaldi M, Costagliola C   +7 more
core  

Cardiovascular events and mortality in adults with late onset seizures: Focus on enzyme‐modulating antiseizure medications

Epilepsia, EarlyView.
Abstract Objective Using a Dutch insurance claims registry, we examine whether people with epilepsy have an increased risk of major ischemic cardiovascular events or death compared to people without epilepsy. We also assess whether this risk differs between users of enzyme‐modulating and non‐enzyme‐modulating antiseizure medications (ASMs).
Paola Vassallo, Nathan A. Shlobin, Mark R. Keezer, Roland D. Thijs, Ley Sander   +4 more
wiley   +1 more source

The Anticoagulation Dilemma: Concurrent Traumatic Brain Hemorrhage and Cerebral Venous Thrombosis in a Blast Injury Patient. [PDF]

Clin Case Rep
ABSTRACT Blast injuries produce complex multi‐system trauma through primary barotrauma, secondary penetrating projectiles, tertiary displacement forces, and quaternary mechanisms. Among the most challenging complications is the concurrent presentation of traumatic intracranial hemorrhage and cerebral venous sinus thrombosis (CVST), which creates a ...
Amare A, Teferi MG, Negasa LM, Haile TA, Bonsu SM, Ageze KP, Minwagaw GT.   +6 more
europepmc   +2 more sources

Phenytoin-Induced Thrombocytopenia

, 1997
Objective To describe a patient with severe thrombocytopenia induced by the administration of phenytoin for prevention of seizures. A review of the literature supplements this case description to alert clinicians to this potentially serious hematologic ...
Lori A Reisner-Keller, Christopher D Holtzer   +1 more
core   +1 more source

Acute effects of anti‐seizure medications on network level dynamics: A systematic comparison using multielectrode arrays

Epilepsia, EarlyView.
Abstract Objective A multi‐electrode array (MEA) is a powerful extracellular recording technique for long‐term monitoring of neuronal network activity. In recent years, MEA‐based assays have been applied increasingly to evaluate drug efficacy and neurotoxicity, including the assessment of anti‐seizure medications (ASMs). However, systematic comparisons
Griselda Marku, Lena Gschossmann, Kerstin Hallmann, Heinz Beck, Kunihiko Araki   +4 more
wiley   +1 more source

Pharmacokinetics of phenytoin following intravenous and intramuscular administration of fosphenytoin and phenytoin sodium in the rabbit

, 2002
The purpose of this study was to evaluate and compare plasma phenytoin concentration versus time profiles following intravenous (i.v) and intramuscular (i.m) administration of fosphenytoin sodium with those obtained following administration of standard ...
Munenge, R. W., S. N. Muchohi, G. Edwards, Kokwaro, G. O., Edwards, Geoffrey, Muchohi, S. N., T. E. Maitho, Maitho, T. E., G. O. Kokwaro, Watkins, W. M., R. W. Munenge, W. M. Watkins   +11 more
core   +1 more source

Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients

Pharmaceuticals, 2018
Background: Phenytoin cream applied topically has been explored in neuropathic pain conditions. In several case series, phenytoin 5% and 10% cream could reduce pain in a clinically relevant way with a fast onset of action within 30 min, and with positive
David J. Kopsky, Jan M. Keppel Hesselink   +1 more
doaj   +1 more source