Results 51 to 60 of about 46,241 (267)

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Reprocessing Mass Spectra from Therapeutic Drug Monitoring to Unveil Proton Pump Inhibitor Use and Quantify Phenoconversion of Escitalopram Metabolism in CYP2C19‐Genotyped Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Escitalopram is a frequently prescribed antidepressant drug. CYP2C19 genotype is a major determinant of escitalopram metabolism and treatment outcome. However, real‐life studies show a high degree of genotype–phenotype mismatch in escitalopram metabolism.
Kristine Hole, Birgit M. Wollmann, Julia Carolin Stingl, Espen Molden   +3 more
wiley   +1 more source

Seizure prophylaxis in young patients following traumatic brain injury

Journal of Emergencies, Trauma and Shock
Introduction: Phenytoin is one of the commonly used anti-seizure medications in nontraumatic seizures. However, its utility and safety in young patients with traumatic brain injury (TBI) for the prevention of early-onset seizures (EOS) are debatable.
Ahmed Abdel-Aziz Bahey, Talat Chughtai, Ayman El-Menyar, Vishwajit Verma, Gustav Strandvik, Mohammad Asim, Rafael Consunji, Basil Younis, Ashok Parchani, Sandro Rizoli, Hassan Al-Thani   +10 more
doaj   +1 more source

Phenytoin Toxicity Treatment with Haemodialysis in Epilepsy due to Glioblastoma Multiforme: Case Report and Review of the Literature

Case Reports in Neurology, 2019
Phenytoin is one of the most commonly used anticonvulsants in the developing world, but lack of monitoring and concurrent medications can easily lead to toxicity.
Karishma Sharma, Aditi Vakil, Ahmed Sokwala, Dilraj Sokhi   +3 more
doaj   +1 more source

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

Drug Testing and Analysis, EarlyView.
Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani, Kirsten L. Rock, Kathleen Rice‐Davies, Rebecca Lo, Benedict Morley, Stephen Morley, Caroline S. Copeland   +6 more
wiley   +1 more source

Phenytoin intoxication with no symptoms correlated with serum drug level: a case study

The Pan African Medical Journal, 2015
In high-dose intake of phenytoin, which is used frequently to treatepilepsy, nystagmus, diplopia, nausea-vomiting, lethargy, confusion, seizure, and coma can be observed.
Mucahit Avcil, Ali Duman, Kenan Ahmet Turkdogan, Mucahit Kapci, Ayhan Akoz, Selcuk Eren Canakci, Yunus Emre Ozluer   +6 more
doaj   +1 more source

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial [PDF]

, 2019
Background Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial
Mackle, Daisy, Lavigne-Smith, Holly R., Fernandez, Daphin, Sajjanhar, Tina, Devine, Kirsty, Morcombe, Julie, Hickey, Helen, Messahel, Shrouk, Parikh, Ami, Ensom, Ruth, Bell, Claire, Downes, Alice J., Evans, Jayne, Maney, Julie Ann, Noblet, Joanne, Greenwood-Bibby, Rachel, Buchanan, Mark, Sunley, Rachel C., Helyer, Sinead, Ramsay, Rebecca, Small, Jennie, Mulligan, Joanne, Hartshorn, Stuart, Laque, Martin, Hardwick, Susie, Faza, Hani, Pereira, Matthew, Sheedy, Alyce B., Choudhery, Vince, Appelboam, Andy, Finucane, Sonya, Ramsey, Natasha, Potier de la Morandiere, Katherine, Lyttle, Mark D., Hughes, Sharon, Ramlakhan, Shammi, Grahamslaw, Julia, Skene, Imogen, Cantle, Fleur, Thomas, Rhys, Hopkins, Juliet, Gamble, Carrol, Moulsdale, Phoebe, Bell, Kathryn, Wilson, Jill L., Woolfall, Kerry, Millar, Muriel, Corrigan, Paul P., Anderson, Mark, Neil, Ashleigh, Criddle, John, Ross, James, Bayreuther, Jane, Gough, Christopher, Iqbal, Yasser, Rogers, Louise, Nyirenda, Maggie, Lewis, Lucy, McLellan, Shona, Evans, Vicki, Smith, Coral J., Dalzell, Elizabeth, Prudhoe, Sarah, Mullen, Niall, Smith, Alice, Bevan, Catherine, Danziger, Donna, Riozzi, Paul, Unsworth, Vanessa, Potter, Sarah, Scott, Alex, Sutherland, Emer, Walton, Emily, MacLeod, Stewart, O'Neill, Thomas, Cotton, Hannah, Hacking, Jo, Gormley, Stuart, Armstrong, Sonia, Lee, Elizabeth D., Rounding, Sarah, Humphreys, Amy, Crome, Laura, Rainford, Naomi E.A., Hay, Felix, Howells, Rachel J., Burke, Derek, Leighton, Shona, Roper, Louise, Appleton, Richard E., Cathie, Katrina, Bingham, Tracey, Browning, Jen, Roland, Damian, Robinson, Gisela, Kumar, Ramesh, Tate, Paul, Barling, Jason M., Mollard, Helen, Iyer, Anand   +99 more
core   +1 more source

The effectiveness of adding on or switching antiseizure medications after the first fails to control focal epilepsy: A systematic review of randomized controlled trials

Epileptic Disorders, EarlyView.
Abstract Focal epilepsy constitutes 60–70% of epilepsy, and up to half of patients do not achieve seizure freedom with their first antiseizure medication (ASM). When the first ASM fails, evidence guiding whether to switch or add‐on another ASM and which ASMs to use is limited. This review synthesized evidence from randomized controlled trials (RCTs) on
Isaac J. Egesa, Gashirai Mbizvo, Michelle Maden, Thomas Spain, Richard Emsley, Laura J. Bonnett, Anthony G. Marson, Catrin Tudur Smith   +7 more
wiley   +1 more source

Comparisons of Four Protein-Binding Models Characterizing the Pharmacokinetics of Unbound Phenytoin in Adult Patients Using Non-Linear Mixed-Effects Modeling

Drugs in R&D, 2020
Background and objective Phenytoin is extensively protein bound with a narrow therapeutic range. The unbound phenytoin is pharmacologically active, but total concentrations are routinely measured in clinical practice.
Heajin Jun, Yan Rong, Catharina Yih, Jordan Ho, Wendy Cheng, Tony K. L. Kiang   +5 more
doaj   +1 more source