Results 41 to 50 of about 45,385 (273)

GRIA2 Variant Associated With Paradoxical Response to Perampanel Expanding the Spectrum of GRIA2‐Related Epileptic Encephalopathy: Case Report and Literature Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata, Chhitij Tiwari, Zheng Fan, Muge Gucsavas‐Calikoglu, Yael Shiloh‐Malawsky, Kimberly S. Foss, Stephanie N. Peck, Erin L. Heinzen, Chon Lee, Senyene E. Hunter   +9 more
wiley   +1 more source

Phenytoin Cream for the Treatment of Neuropathic Pain: Case Series

Pharmaceuticals, 2018
BACKGROUND: Neuropathic pain can be disabling, and is often difficult to treat. Within a year, over half of all patients stop taking their prescribed neuropathic pain medication, which is most probably due to side effects or disappointing analgesic ...
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +1 more source

Dl-3-n-butylphthalide inhibits phenytoin-induced neuronal apoptosis in rat hippocampus and cerebellum [PDF]

Journal of Integrative Neuroscience, 2019
Rats were divided into six groups: sham/control, Dl-3-n-butylphthalide, P1 (low phenytoin, 100 mg/kg), P2 (high phenytoin, 200 mg/kg), NP1 (Dl-3-n-butylphthalide 80 mg/kg, phenytoin 100 mg/kg), NP2 (Dl-3-n-butylphthalide 80 mg/kg, phenytoin 200 mg/kg ...
Junmin Chen, Na Liu, Xiaopeng Wang, Yanying Zhao, Junna He, Lan Yang, Qian Sun, Jing Zhao, Linjing Wang, Lei Chen
doaj   +1 more source

Population pharmacokinetics of Phenytoin in critically ill children

, 2014
The objective was to study the population pharmacokinetics of bound and unbound phenytoin in critical ill children, including influences on the protein binding profile.
Karin van Breda, Norris, Ross, Kelly Foster, Tu, Quyen Tu, Riney, Kate, van Breda, Karin, Hennig, Stefanie, Kate Riney, Bruce Charles, Stefanie Hennig, Bruce Lister, Foster, Kelly, Quyen Tu, Lister, Bruce, Charles, Bruce, Tu, Quyen, Ross Norris   +16 more
core   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Fixed Drug Eruption in an Epileptic Patient Previously Receiving Treatment With Phenytoin for Seven Years

Journal of Investigative Medicine High Impact Case Reports, 2013
A 52-year-old African American female presented with severe left thigh pain of unknown etiology. She had a past medical history of generalized seizure disorder treated with phenytoin for 7 years without incident.
Keaton S. Smetana, Katie J. Suda PharmD, MS, Leslie A. Hamilton PharmD   +2 more
doaj   +1 more source

PHENYTOIN INDUCED TOXIC EPIDERMAL NECROLYSIS; A CASE REPORT

, 2017
Several drugs are at high risk of causing Toxic Epidermal Necrolysis (TEN) including Anti-convulsants such as phenytoin, carbamazepine and phenobarbital.
PHENYTOIN INDUCED TOXIC EPIDERMAL NECROLYSIS; A CASE REPORT Merphin Philip Thomas*1, Miriam Lalmuanpuii Hnamte1, Sina Zare1, Teena Nazeem
core   +1 more source

Cenobamate use in super‐refractory status epilepticus: A report of three cases

Epileptic Disorders, EarlyView.
Abstract Objectives Super‐refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited. Methods This retrospective case series reports the use of cenobamate as add‐on therapy in the management of three cases of ...
Marina Romozzi, Juan Luis Alcala‐Zermeno, Antonio Funcis, Federico Tosto, Marta Piccioli, Luigi Francesco Iannone, Riccardo Maviglia, Masahito Katsuki, Yasuhiko Matsumori, Paolo Calabresi, Raffaele Iorio, Catello Vollono   +11 more
wiley   +1 more source