Results 21 to 30 of about 36,215 (230)

Total Phenytoin concentration is not well correlated with active free drug in critically-ill head trauma patients

Journal of Research in Pharmacy Practice, 2013
Objective: Phenytoin is an antiepileptic drug used widely for prophylaxis and treatment of seizure after neurotrauma. Phenytoin has a complex pharmacokinetics and monitoring of its serum concentrations is recommended during treatment.
Kourosh Sadeghi, Farin Hadi, Arezoo Ahmadi, Hadi Hamishehkar, Mohammad-Taghi Beigmohammadi, Ata Mahmoodpoor, Mohammad Reza Rouini, Shirin Farhudi, Narjes Hendoui, Atabak Najafi, Mojtaba Mojtahedzadeh   +10 more
doaj   +1 more source

Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2018
Objective(s): Phenytoin is an antiepileptic drug that is used worldwide.The whole-body pharmacokinetics of this drug have been extensivelystudied using 11C-phenytoin in small animals.
Yasukazu Kanai, Yoshinori Miyake, Jun Hatazawa   +2 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A case of phenytoin toxicity in an adolescent girl mimicking meningoencephalitis and literature review

Journal of Integrative Medicine and Research, 2023
The zero-order pharmacokinetics of phenytoin makes it a serious problem in pediatric emergency care since it can cause considerable dose-related toxicity.
Jenith Vijayalakshmi, Vetsa Snigdha Hasa, Manas Ranjan Behera, Mukesh Kumar Jain, Nirmal Kumar Mohakud   +4 more
doaj   +1 more source

The Case of a 40‐Year‐Old Man With New‐Onset Status Epilepticus in the Setting of HIV Infection

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 40‐year‐old man from Andhra Pradesh in India, while on regular antiretroviral treatment (ART) for long‐standing HIV infection presented with a 1‐day history of new‐onset status epilepticus. CT and MRI brain showed multifocal cerebral ring lesions, some of which demonstrated characteristic ‘hole‐with‐a‐dot’ sign.
Vadde Akhil, Ramachandiran Nandhagopal
wiley   +1 more source

Fetal hypoxia and hyperglycemia in the formation of phenytoin‐induced cleft lip and maxillary hypoplasia

Epilepsia Open, 2019
Objective Phenytoin exposure during the first trimester of pregnancy increases the risk of maxillary hypoplasia and cleft lip. The etiology of phenytoin embryopathy is unknown.
Helen E. Ritchie, Diana Oakes, Emma Farrell, Deena Ababneh, Andrew Howe   +4 more
doaj   +1 more source

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith, Matthew McCord, Jaideep Kapur, Mark Quigg, Catherine Joshua, Ifrah Zawar   +7 more
wiley   +1 more source

Dl-3-n-butylphthalide inhibits phenytoin-induced neuronal apoptosis in rat hippocampus and cerebellum [PDF]

Journal of Integrative Neuroscience, 2019
Rats were divided into six groups: sham/control, Dl-3-n-butylphthalide, P1 (low phenytoin, 100 mg/kg), P2 (high phenytoin, 200 mg/kg), NP1 (Dl-3-n-butylphthalide 80 mg/kg, phenytoin 100 mg/kg), NP2 (Dl-3-n-butylphthalide 80 mg/kg, phenytoin 200 mg/kg ...
Junmin Chen, Na Liu, Xiaopeng Wang, Yanying Zhao, Junna He, Lan Yang, Qian Sun, Jing Zhao, Linjing Wang, Lei Chen
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Phenytoin Cream for the Treatment of Neuropathic Pain: Case Series

Pharmaceuticals, 2018
BACKGROUND: Neuropathic pain can be disabling, and is often difficult to treat. Within a year, over half of all patients stop taking their prescribed neuropathic pain medication, which is most probably due to side effects or disappointing analgesic ...
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +1 more source