Clinical Pharmacology: Advances and Applications, 2018 Seyyede-Sareh Javadi,1 Reza Mahjub,2 Abbas Taher,3 Younes Mohammadi,4 Maryam Mehrpooya1 1Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Pharmaceutics, School of Pharmacy, Hamadan
Javadi SS +4 more
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Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report
International Medical Case Reports Journal, 2017 Ashwin Kodliwadmath Department of Medicine, Belgaum Institute of Medical Sciences, Belgaum, India Abstract: Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the ...
Kodliwadmath A
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The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin. [PDF]
Clin Pharmacol TherDicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Shaul C +5 more
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Contributions to an improved phenytoin monitoring and dosing in hospitalized patients [PDF]
, 2016 Phenytoin (PHT) is one of the mostly used and well established anticonvulsants for the treatment of epilepsy and a standard in the antiepileptic prophylaxis in adults with severe traumatic brain injuries before and after neurosurgical intervention. Its
Tobler-Giger, Andrea
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Phenytoin Toxicity with High Dose, Concomitant Ascorbic Acid Dosing
INNOVATIONS in Pharmacy, 2022 High dose ascorbic acid may increase risk of phenytoin toxicity. This case report demonstrates high phenytoin levels resulting in adverse drug reactions subsequent to dosing concomitantly with high dose vitamin C, or ascorbic acid (AA), as a precaution ...
Michael J. Schuh +2 more
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Anticonvulsant Effect of Nebivolol alone and in Combination with Phenytoin against Maximal Electroshock-Induced Seizures in Mice [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Phenytoin is widely used in treatment of generalised tonic clonic seizures but its adverse effects make its usage limited. Hence forth, there is a need for newer antiepileptics. Studies have shown antiepileptic property for nebivolol in
Anuranjani Dhamodharan +2 more
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The Possible Protective Role of Selenium Against Long-Term Phenytoin Administration Effects on Cerebellar Cortex of Adult Male Albino Rats: Histological and Immunohistochemical Study [PDF]
The Egyptian Journal of Histology, 2020 Background: Phenytoin is a commonly prescribed antiepileptic drug. Chronic phenytoin treatment has been documented to be associated with cerebellar degeneration.
Enas Bekheet
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Phenytoin Versus Levetiracetam for Post-traumatic Seizure Prophylaxis
, 2021 Objective:This study aimed to compare the efficacy of levetiracetam versus phenytoin in early post-traumatic seizure prevention and ascertain the incidence of clinical seizures in traumatic brain injury (TBI).Materials and Methods: Adult patients with ...
Barış Yılmaz +7 more
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CYP2C9 polymorphisms are associated with phenytoin toxicity in South-Indian epileptic patients
Journal of Dr. NTR University of Health Sciences, 2020 Background and Aims: The contribution of CYP2C9 in phenytoin metabolism is generally modest, but it increases with increasing serum phenytoin concentration.
Rakesh Reddy Reddigari +4 more
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Phenytoin regulates osteogenic differentiation of human bone marrow stem cells by PI3K/Akt pathway
Regenerative Therapy, 2023 Background: We mainly studied the mechanism by which phenytoin promotes osteogenic differentiation of human jawbone marrow stem cells. Methods: Bone marrow stem cells were extracted from jaw bone tissue debris obtained from 5 subjects undergoing implant ...
Zeliang Zhang +3 more
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