Results 31 to 40 of about 64,482 (277)
Journal of Research in Pharmacy Practice, 2013 Objective: Phenytoin is an antiepileptic drug used widely for prophylaxis and treatment of seizure after neurotrauma. Phenytoin has a complex pharmacokinetics and monitoring of its serum concentrations is recommended during treatment.
Kourosh Sadeghi +10 more
doaj +1 more source
Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2018 Objective(s): Phenytoin is an antiepileptic drug that is used worldwide.The whole-body pharmacokinetics of this drug have been extensivelystudied using 11C-phenytoin in small animals.
Yasukazu Kanai +2 more
doaj +1 more source
Predictors of Extra Care Among Magnesium Sulphate treated eclamptic patients at Muhimbili National Hospital, Tanzania. [PDF]
, 2011 \ud The inclusion of Magnesium Sulphate (MgSO4) as a gold standard in the treatment of eclampsia has substantially reduced incidences of repeated fits, eclamptic morbidity and deaths.
Muganyizi, Projestine S +1 more
core +4 more sources
The Cerebellum and SIDS: Disordered Breathing in a Mouse Model of Developmental Cerebellar Purkinje Cell Loss during Recovery from Hypercarbia. [PDF]
, 2016 The cerebellum assists coordination of somatomotor, respiratory, and autonomic actions. Purkinje cell alterations or loss appear in sudden infant death and sudden death in epilepsy victims, possibly contributing to the fatal event. We evaluated breathing
Calton, Michele A +4 more
core +2 more sources
Epilepsia Open, 2019 Objective Phenytoin exposure during the first trimester of pregnancy increases the risk of maxillary hypoplasia and cleft lip. The etiology of phenytoin embryopathy is unknown.
Helen E. Ritchie +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
Journal of Integrative Medicine and Research, 2023 The zero-order pharmacokinetics of phenytoin makes it a serious problem in pediatric emergency care since it can cause considerable dose-related toxicity.
Jenith Vijayalakshmi +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Dl-3-n-butylphthalide inhibits phenytoin-induced neuronal apoptosis in rat hippocampus and cerebellum [PDF]
Journal of Integrative Neuroscience, 2019 Rats were divided into six groups: sham/control, Dl-3-n-butylphthalide, P1 (low phenytoin, 100 mg/kg), P2 (high phenytoin, 200 mg/kg), NP1 (Dl-3-n-butylphthalide 80 mg/kg, phenytoin 100 mg/kg), NP2 (Dl-3-n-butylphthalide 80 mg/kg, phenytoin 200 mg/kg ...
Junmin Chen, Na Liu, Xiaopeng Wang, Yanying Zhao, Junna He, Lan Yang, Qian Sun, Jing Zhao, Linjing Wang, Lei Chen
doaj +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source