Results 31 to 40 of about 45,385 (273)
Phenytoin-induced rhabdomyolysis [PDF]
, 2021 Rhabdomyolysis is a potentially life-threatening syndrome that can develop from a variety of causes. The most common causes are muscle injury, alcohol abuse, drugs, toxins and increased muscular activity.
Guler, Selda K. +2 more
core +1 more source
Journal of Research in Pharmacy Practice, 2013 Objective: Phenytoin is an antiepileptic drug used widely for prophylaxis and treatment of seizure after neurotrauma. Phenytoin has a complex pharmacokinetics and monitoring of its serum concentrations is recommended during treatment.
Kourosh Sadeghi +10 more
doaj +1 more source
Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2018 Objective(s): Phenytoin is an antiepileptic drug that is used worldwide.The whole-body pharmacokinetics of this drug have been extensivelystudied using 11C-phenytoin in small animals.
Yasukazu Kanai +2 more
doaj +1 more source
Epilepsia Open, 2019 Objective Phenytoin exposure during the first trimester of pregnancy increases the risk of maxillary hypoplasia and cleft lip. The etiology of phenytoin embryopathy is unknown.
Helen E. Ritchie +4 more
doaj +1 more source
Effects of phenytoin on synthesis of bone morphogenetic proteins (BMPs) in normal human bone cells in vitro [PDF]
, 1999 P(論文)The present study was undertaken to examine the effect of phenytoin on the synthesis of bone morphogenetic proteins (BMPs). The effects of phenytoin on the gene expression of BMP-1-7 in normal human mandible-derived bone cells (HOB-M cells) were ...
賀来, 亨 +7 more
core
Ceftriaxone‐induced liver injury: Incidence, phenotypic characterization and predictive factors
British Journal of Clinical Pharmacology, EarlyView.Introduction Ceftriaxone is a widely used third‐generation cephalosporin in hospitalized patients. Although generally considered safe, it has been associated with hepatobiliary complications and emerging reports of drug‐induced liver injury (DILI). However, data on its true incidence, phenotypic patterns, and predictors remain limited. This study aimed
Mohamed Hatem +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson +8 more
wiley +1 more source
Journal of Integrative Medicine and Research, 2023 The zero-order pharmacokinetics of phenytoin makes it a serious problem in pediatric emergency care since it can cause considerable dose-related toxicity.
Jenith Vijayalakshmi +4 more
doaj +1 more source
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial [PDF]
, 2019 Background Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial
Mackle, Daisy +99 more
core +1 more source
CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension
British Journal of Clinical Pharmacology, EarlyView.Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien +7 more
wiley +1 more source