Results 61 to 70 of about 36,215 (230)

Pharmacokinetic behavior of phenytoin in head trauma and cerebrovascular accident patients in an iranian population

Journal of Research in Pharmacy Practice, 2017
Objective: Acute brain injury is one of the leading causes of morbidity and mortality worldwide. Phenytoin has been commonly used as an anticonvulsant agent for the treatment or prophylaxis of seizures following acute brain injury.
Shahnaz Alimardani, Sima Sadrai, Hamidreza Taghvaye Masoumi, Pooneh Salari, Atabak Najafi, Behzad Eftekhar, Mojtaba Mojtahedzadeh   +6 more
doaj   +1 more source

Cardiovascular events and mortality in adults with late onset seizures: Focus on enzyme‐modulating antiseizure medications

Epilepsia, EarlyView.
Abstract Objective Using a Dutch insurance claims registry, we examine whether people with epilepsy have an increased risk of major ischemic cardiovascular events or death compared to people without epilepsy. We also assess whether this risk differs between users of enzyme‐modulating and non‐enzyme‐modulating antiseizure medications (ASMs).
Paola Vassallo, Nathan A. Shlobin, Mark R. Keezer, Roland D. Thijs, Ley Sander   +4 more
wiley   +1 more source

Plasmapheresis as an Adjunctive Therapy in Phenytoin Poisoning

Global Journal of Transfusion Medicine
Phenytoin is frequently used as an anticonvulsant. Phenytoin has saturable metabolic kinetics in overdose circumstances, making therapy challenging. Because of its high protein binding property, the usual hemodialysis and hemoperfusion are not usually ...
Purshotam Paudel, Dibyajyoti Sahoo, Abhishekh Basavarajegowda, Raushan Afroz   +3 more
doaj   +1 more source

Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients

Pharmaceuticals, 2018
Background: Phenytoin cream applied topically has been explored in neuropathic pain conditions. In several case series, phenytoin 5% and 10% cream could reduce pain in a clinically relevant way with a fast onset of action within 30 min, and with positive
David J. Kopsky, Jan M. Keppel Hesselink   +1 more
doaj   +1 more source

Does stereoelectroencephalographic depth electrode insertion alter seizure frequency? A baseline versus endpoint analysis

Epilepsia, EarlyView.
Abstract The implantation effect refers to a transient reduction in seizure frequency following intracranial electrode insertion in patients with epilepsy, independent of therapeutic intervention. This retrospective study examined potential clinical and demographic predictors of the implantation effect in 51 patients who underwent ...
Shreyashish Roy‐Chowdhury, Jorge G. Burneo, Juan Toro‐Perez, David A. Steven, Michelle Lee‐Jones, Keith MacDougall, Jonathan Lau, Richard S. McLachlan, Ana Suller Marti   +8 more
wiley   +1 more source

Phenytoin and gingival mucosa: A molecular investigation

International Journal of Immunopathology and Pharmacology, 2019
Several distinct classes of drugs, such as anticonvulsants, immunosuppressants, and calcium channel blockers, caused gingival overgrowth. One of the main drugs associated with the gingival overgrowth is the anti-epileptic such as phenytoin, which affects
Valentina Candotto, Furio Pezzetti, Alessandro Baj, Giada Beltramini, Dorina Lauritano, Michele Di Girolamo, Francesca Cura   +6 more
doaj   +1 more source

Acute effects of anti‐seizure medications on network level dynamics: A systematic comparison using multielectrode arrays

Epilepsia, EarlyView.
Abstract Objective A multi‐electrode array (MEA) is a powerful extracellular recording technique for long‐term monitoring of neuronal network activity. In recent years, MEA‐based assays have been applied increasingly to evaluate drug efficacy and neurotoxicity, including the assessment of anti‐seizure medications (ASMs). However, systematic comparisons
Griselda Marku, Lena Gschossmann, Kerstin Hallmann, Heinz Beck, Kunihiko Araki   +4 more
wiley   +1 more source

Phenytoin Concentrations in Biological Fluids of Traumatic Brain Injury Patients [PDF]

ImmunoAnalysis
Background: This study aims to determine and compare phenytoin concentrations in cerebrospinal fluid (CSF), serum, and urine. In addition, it strives to investigate their inter-correlations to provide insight into alternative monitoring methods. Methods:
Atefeh Razavi, Ali Meshkini, Mohammad Reza Afshar Mogaddam, Behrouz Seyfinejad, Maryam Khoubnasabjafari   +4 more
doaj   +1 more source

Neonatal seizures: Advances in diagnosis and management

Epilepsia Open, EarlyView.
Abstract The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of ...
Elissa G. Yozawitz, Ronit M. Pressler, Eli M. Mizrahi   +2 more
wiley   +1 more source

Intraoperative electrocorticography guiding surgical resection in epilepsia partialis continua secondary to cardiac myxoma embolism: A clinical vignette

Epileptic Disorders, EarlyView.
Olalla Urdanibia‐Centelles, Annette Sidaros, Per Jensen, Ioannis Tsiropoulos, Giulia Primicerio, Trine Jessen, Rune Rasmussen, Jon Foss‐Skiftesvik   +7 more
wiley   +1 more source