Results 61 to 70 of about 46,241 (267)
Epileptic Disorders, EarlyView.Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen +4 more
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Objective To compare the incidence of hostility‐ and aggression‐related adverse events in children with focal‐onset seizures (FOS), with or without focal to bilateral tonic–clonic seizures (FBTCS), receiving perampanel as monotherapy or in combination with other antiseizure medications (ASMs).
Yukitoshi Takahashi +5 more
wiley +1 more source
The retinoprotective role of phenytoin
, 2018 Silvia Bartollino,1 Flavia Chiosi,1 Silvio di Staso,2 Maurizio Uva,3 Arduino Pascotto,1 Michele Rinaldi,4 Jan M Keppel Hesselink,5 Ciro Costagliola1 1Eye Clinic, Department of Medicine and Health Sciences “V.
Chiosi F +7 more
core
The effect of anti‐seizure medications on exposure to statins: A systematic review and meta‐analysis
Epileptic Disorders, EarlyView.Abstract Objectives Antiseizure medications (ASMs) can reduce the efficacy of statin treatment, partly due to reduction in statin concentrations. In this systematic review and network meta‐analysis (NMA), we compared the effects of ASMs and the prototypical enzyme inducer rifampin on statin exposure.
Sharon Valiyev Huino +5 more
wiley +1 more source
IV Levetiracetam versus IV Phenytoin in childhood seizures: A randomized controlled trial
Journal of Pediatric Neurosciences, 2018 Objectives: To compare the efficacy of IV phenytoin and IV levetiracetam in acute seizures. Design: Randomized controlled trial. Setting: Tertiary care hospital, November 2012 to April 2014.
Kanika Singh +3 more
doaj +1 more source
Phenytoin for neuroprotection [PDF]
The Lancet Neurology, 2016 Elena H, Martinez-Lapiscina +3 more
openaire +5 more sources
Epilepsia, EarlyView.Abstract Objective A multi‐electrode array (MEA) is a powerful extracellular recording technique for long‐term monitoring of neuronal network activity. In recent years, MEA‐based assays have been applied increasingly to evaluate drug efficacy and neurotoxicity, including the assessment of anti‐seizure medications (ASMs). However, systematic comparisons
Griselda Marku +4 more
wiley +1 more source
Phenytoin: A Guide to Therapeutic Drug Monitoring
Proceedings of Singapore Healthcare, 2013 Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics.
Melissa Faye Wu BSc (Pharm) (Hons) +1 more
doaj +1 more source
Topical phenytoin for the treatment of neuropathic pain
, 2017 David J Kopsky,1 Jan M Keppel Hesselink2 1Institute for Neuropathic Pain, Amsterdam, 2Institute for Neuropathic Pain, Bosch en Duin, the Netherlands Abstract: We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin ...
Kopsky DJ, Keppel Hesselink JM
core
Sertraline and Phenytoin Drug Interaction in a Geriatric Patient
, 2017 This report presents the case of a 78-year-old man residing in a nursing home who presented with a 2-month history of increasing lethargy and confusion. These symptoms coincided with the initiation of sertraline in the patient.
Thomas V Caprio +9 more
core +1 more source