Results 81 to 90 of about 46,241 (267)

Genotypes and Phenytoin Dosing: 2020 Update

, 2021
Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9.
Adrian Llerena, Fohner, Alison E., Jason H. Karnes, Kelly E. Caudle, Allan E. Rettie, Andrew A. Somogyi, Somogyi, Andrew A., Ming Ta Michael Lee, Michelle Whirl‐Carrillo, Lee, Ming Ta Michael, Alison E. Fohner, Karnes, Jason H., Rettie, Allan E., Phillips, Elizabeth J., Llerena, Adrian, Klein, Teri E., Huddart, Rachel, Elizabeth J. Phillips, Mintzer, Scott, Whirl-Carrillo, Michelle, John T. Callaghan, Andrea Gaedigk, Gaedigk, Andrea, Rachel Huddart, Caudle, Kelly E., Christine M. Formea, Formea, Christine M., Scott Mintzer, Teri E. Klein, Callaghan, John T.   +29 more
core   +1 more source

Neonatal seizures: Advances in diagnosis and management

Epilepsia Open, EarlyView.
Abstract The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of ...
Elissa G. Yozawitz, Ronit M. Pressler, Eli M. Mizrahi   +2 more
wiley   +1 more source

Plasmapheresis as an Adjunctive Therapy in Phenytoin Poisoning

Global Journal of Transfusion Medicine
Phenytoin is frequently used as an anticonvulsant. Phenytoin has saturable metabolic kinetics in overdose circumstances, making therapy challenging. Because of its high protein binding property, the usual hemodialysis and hemoperfusion are not usually ...
Purshotam Paudel, Dibyajyoti Sahoo, Abhishekh Basavarajegowda, Raushan Afroz   +3 more
doaj   +1 more source

Phenytoin-induced parkinsonism.

, 2006
This report presents a 30-year-old man who developed subacute phenytoin-induced cerebellar ataxia and parkinsonism that resolved after discontinuation of the phenytoin treatment. Phenytoin was started for seizure prophylaxis in another health institution
Ertan, S., Hanimoglu, H., Kafadar, ALİ METİN, Acar, Z.U., Kiziltan, Güneş, ULU, Melek, TANRIVERDİ, Taner   +6 more
core  

Significant Inhibition of Protein Binding of Phenytoin [PDF]

, 2018
Aim: This research was aimed to assess the potential for inhibition of protein binding of phenytoin by tizoxanide in human plasma. Phenytoin was used because studies have proven to be a highly plasma protein-bound drug with a narrow therapeutic index and
Babayeva, Mariana, Alexander, Sheril, Mariana Babayeva, Flores, Jesse, Henrietta Ofuluozor, Sheril Alexander, Jesse Flores, Ofuluozor, Henrietta   +7 more
core   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Phenytoin and gingival mucosa: A molecular investigation

International Journal of Immunopathology and Pharmacology, 2019
Several distinct classes of drugs, such as anticonvulsants, immunosuppressants, and calcium channel blockers, caused gingival overgrowth. One of the main drugs associated with the gingival overgrowth is the anti-epileptic such as phenytoin, which affects
Valentina Candotto, Furio Pezzetti, Alessandro Baj, Giada Beltramini, Dorina Lauritano, Michele Di Girolamo, Francesca Cura   +6 more
doaj   +1 more source

Noncompliance leading to drug accumulation resulting in phenytoin toxicity

, 2003
Phenytoin is effective in suppressing tonic-clonic and partial seizures, and is widely used for initial therapy, particularly in adults. Ninety percent of phenytoin is protein bound and entirely eliminated by hepatic metabolism.
Akula, Ravi, Hasan, Syed, Ferguson, Clifford, Pipalla, Rao   +3 more
core   +1 more source

Phenytoin-Induced Thrombocytopenia

, 1997
Objective To describe a patient with severe thrombocytopenia induced by the administration of phenytoin for prevention of seizures. A review of the literature supplements this case description to alert clinicians to this potentially serious hematologic ...
Lori A Reisner-Keller, Christopher D Holtzer   +1 more
core   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source