Results 91 to 100 of about 64,482 (277)
Self‐limited neonatal epilepsy with 2q24.3 duplications: Case series and literature review
Epileptic Disorders, EarlyView.Abstract Objective To clarify the phenotypic spectrum associated with duplications involving the 2q24.3 region, which includes a cluster of genes encoding sodium channel subunits (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A). Methods We reviewed our research database for patients with epilepsy and 2q24.3 duplication and performed thorough phenotyping.
Saba Al Rawahi, Kenneth A. Myers
wiley +1 more source
Plasmapheresis as an Adjunctive Therapy in Phenytoin Poisoning
Global Journal of Transfusion MedicinePhenytoin is frequently used as an anticonvulsant. Phenytoin has saturable metabolic kinetics in overdose circumstances, making therapy challenging. Because of its high protein binding property, the usual hemodialysis and hemoperfusion are not usually ...
Purshotam Paudel +3 more
doaj +1 more source
Era of direct acting anti-viral agents for the treatment of hepatitis C. [PDF]
, 2018 Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone.
Ahmed, Monjur
core +1 more source
, 2014 Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
core +2 more sources
Mechanisms of SCN2A loss of function do not predict presence or phenotype of epilepsy
Epilepsia, EarlyView.Abstract Objective SCN2A loss‐of‐function (LoF) variants are associated with epilepsy (onset age ≥ 3 months), intellectual disability (ID), and autism spectrum disorder (ASD). Despite numerous identified variants and the description of phenotypic subgroups, relationships between Nav1.2 channel dysfunction and clinical phenotypes remain unclear.
Marsha Tan +23 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz +10 more
wiley +1 more source
Phenytoin Concentrations in Biological Fluids of Traumatic Brain Injury Patients [PDF]
ImmunoAnalysisBackground: This study aims to determine and compare phenytoin concentrations in cerebrospinal fluid (CSF), serum, and urine. In addition, it strives to investigate their inter-correlations to provide insight into alternative monitoring methods. Methods:
Atefeh Razavi +4 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin +7 more
wiley +1 more source
Are Excipients Inert? Phenytoin Pharmaceutical Investigations with New Incompatibility Insights
Journal of Pharmacy & Pharmaceutical Sciences, 2018 PURPOSE: The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to aid in the manufacturing process and enhance stability, bioavailability, safety ...
Daniela Amaral Silva +2 more
doaj +1 more source
Rapid recovery after intrathecal dexamethasone in FIRES
Epileptic Disorders, EarlyView.
João Filipe Nico +8 more
wiley +1 more source