Results 191 to 200 of about 93,963 (358)

Therapeutic Drug Safety, Important to ‘Close the Gap’ for Aboriginal and Torres Strait Islanders: A Case of Phenytoin Hypersensitivity Syndrome [PDF]

, 2018

openalex   +1 more source

Identification of New KCNT1‐Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling

Annals of Neurology, Volume 98, Issue 6, Page 1261-1274, December 2025.
Objective Hyperactive KCNT1 potassium channels, caused by gain‐of‐function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug‐resistant seizures and, in cases with infantile onset, developmental regression can follow.
Michael G. Ricos, Bethan A. Cole, Rashid Hussain, Grigori Y. Rychkov, Zeeshan Shaukat, Nadia Pilati, Stephen P. Muench, Katie J. Simmons, Leanne M. Dibbens, Jonathan D. Lippiat   +9 more
wiley   +1 more source

Postoperative seizure prophylaxis after craniotomy: a current evidence and ongoing controversy. [PDF]

Ann Med Surg (Lond)
Gould J, Patel S, Chaurasia B.
europepmc   +1 more source

Mitochondrial HMG‐CoA Synthase Deficiency Presenting as Pediatric Metabolic Stroke: A Case Report of a Novel Homozygous HMGCS2 (p.Ile56Asn) Variant

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Mitochondrial HMG‐CoA synthase deficiency should be suspected in infants with hypoketotic hypoglycemia, metabolic acidosis, and basal ganglia lesions. A 2‐year‐old boy with a novel HMGCS2 variant presented with refractory seizures and encephalopathy, highlighting the need for rapid metabolic and genetic evaluation for timely management.
Yasmeen Alshami, Osama Hroub, Mohammad Hroub, Saja Abouodeh, Zahra Makhamre, Ahmad G. Hammouri, Ibrahim Alzatari, Osama Atawneh   +7 more
wiley   +1 more source

Effects of Phenytoin on the Retinal Ganglion Cell-Inner Plexiform Layer in Acute Optic Neuritis: Analysis of a Phase II Randomized Trial. [PDF]

Neurology
Kodali S, Bianchi A, Raftopoulos R, Moccia M, Malladi AP, Yiannakas MC, Fugger M, Samson RS, Wheeler-Kingshott CAM, Koltzenburg M, Prados F, Hickman S, Kapoor R, Toosy AT.   +13 more
europepmc   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1499-1511, December 2025.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Effects of Antiepileptic Drugs, Carbamazepine and Phenytoin, on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in Japanese Patients With Schizophrenia. [PDF]

Neuropsychopharmacol Rep
Ikawa K, Imura T, Nakamura S, Murata K, Morikawa N, Sakata M, Yasuzawa H, Horikawa N.   +7 more
europepmc   +1 more source

Nerve conduction velocity in patients under longterm treatment with antiepileptic drugs [PDF]

, 1990
Berlit, Peter, Krause, Klaus-Henning
core  

Particle size distribution affects the human bioavailability of phenytoin.

, 1986
SHIGERU YAKOU, Sachiko Yamazaki, Takashi Sonobe, MASAYASU SUGIHARA, Kenji Fukumuro, Tsuneji Nagai   +5 more
openalex   +2 more sources

Phenytoin absorption in patients with ileojejunal bypass. [PDF]

, 1979
Kennedy Mc, DN Wade
openalex   +1 more source