Results 211 to 220 of about 45,385 (273)
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The bioavailability of phenytoin
Journal of Neurology, 1977The bioavailability of three commercial products of phenytoin (Epanutin, sodium salt; Phenhydan, calcium salt; Zentropil, free acid) was studied relative to a standard solution of sodium phenytoin. Each preparation was given for 14 days in a daily dose of 300 mg according to a cross over design.
R, Gugler +3 more
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Annals of Internal Medicine, 1989
Excerpt To the Editor:We read with interest the recent letter (1) in which antiseizure prophylaxis was recommended for patients receiving high-dose busulphan, 16 mg/kg body weight over 4 consecutiv...
A P, Grigg, J D, Shepherd, G L, Phillips
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Excerpt To the Editor:We read with interest the recent letter (1) in which antiseizure prophylaxis was recommended for patients receiving high-dose busulphan, 16 mg/kg body weight over 4 consecutiv...
A P, Grigg, J D, Shepherd, G L, Phillips
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Bioavailability and pharmacokinetics of phenytoin during pregnancy
European Journal of Clinical Pharmacology, 1984 Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug.
Maree Smith, C M Lander
exaly +2 more sources
Reactions Weekly, 2018 Phenytoin is a first-generation antiepileptic drug characterized by a good range of antiepileptic indications, with an acceptable interaction profile in polytherapy.
Andrea E. Cavanna
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Medical Journal of Australia, 1979
Large doses (up to 1200 mg) of phenytoin were required to achieve therapeutic plasma concentrations and to control post-traumatic seizures in a 62-year-old woman. The elimination half-life of phenytoin was calculated to be 3.5 hours. Frequent monitoring of the plasma concentration was essential to optimize the therapeutic control and to avoid systemic ...
C G, Meredith +3 more
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Large doses (up to 1200 mg) of phenytoin were required to achieve therapeutic plasma concentrations and to control post-traumatic seizures in a 62-year-old woman. The elimination half-life of phenytoin was calculated to be 3.5 hours. Frequent monitoring of the plasma concentration was essential to optimize the therapeutic control and to avoid systemic ...
C G, Meredith +3 more
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Southern Medical Journal, 1991
We studied the clinical features of 85 cases of phenytoin toxicity in 76 patients treated at a general hospital. Serum levels of phenytoin on admission ranged from 30.3 to 95.0 micrograms/mL (median, 46.5). Iatrogenic causes of intoxication were common and included increased daily dosage and intravenous loading in the emergency room for single seizures
J M, Murphy, R, Motiwala, O, Devinsky
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We studied the clinical features of 85 cases of phenytoin toxicity in 76 patients treated at a general hospital. Serum levels of phenytoin on admission ranged from 30.3 to 95.0 micrograms/mL (median, 46.5). Iatrogenic causes of intoxication were common and included increased daily dosage and intravenous loading in the emergency room for single seizures
J M, Murphy, R, Motiwala, O, Devinsky
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Phenytoin Toxicity Secondary to an Oxcarbazepine-Phenytoin 2C19 Interaction
Psychosomatics, 2010Polytherapy is common in the management of bipolar disorder, as are the side effects associated with this treatment strategy.The authors review the literature on drug-drug interactions involving oxcarbazepine and identify specific mechanisms that may have clinical importance.The authors provide a case report of a patient who developed phenytoin ...
David P, Soskin +2 more
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Phenytoin and Fluorouracil Interaction
Annals of Pharmacotherapy, 2001OBJECTIVE: To report a probable drug interaction between phenytoin and fluorouracil. CASE REPORT: A 66-year-old white man started adjuvant chemotherapy for colon cancer with weekly bolus injections of fluorouracil and leucovorin ...
Gilbar, PJ, Brodribb, TR
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