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Phenytoin therapy

Clinical Pharmacology & Therapeutics, 1978
I wish to point out a significant error in the article by Peter W. Mullen, “Optimal phenytoin therapy: A new technique for individualizing dosage,” which appeared on page 228 of the February, 1978, issue of the Journal. In Table I, the serum phenytoin concentrations he predicted by using the method described by Ludden and colleagues (Clin.
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Phenytoin Poisoning

Neurocritical Care, 2005
Phenytoin toxicity may result from intentional overdose, dosage adjustments, drug interactions, or alterations in physiology. Intoxication manifests predominantly as nausea, central nervous system dysfunction (particularly confusion, nystagmus, and ataxia), with depressed conscious state, coma, and seizures occurring in more severe cases.
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Phenytoin

Reactions Weekly, 2018
Phenytoin is a first-generation antiepileptic drug characterized by a good range of antiepileptic indications, with an acceptable interaction profile in polytherapy. The reasons for the decreased use of phenytoin in patients with epilepsy include its narrow therapeutic index and potential for long-term toxicity, as well as the development of other ...
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Phenytoin toxicity

BMJ Case Reports, 2022
Avivar Awasthi   +3 more
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Phenytoin Toxicity

JAMA, 2017
Arjun, Gupta   +2 more
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Phenytoin hypersensitivity

Journal of Allergy and Clinical Immunology, 1980
S H, Josephs, S J, Rothman, R H, Buckley
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PHENYTOIN ENCEPHALOPATHY?

The Lancet, 1971
, Engel, M E, Cruz, B, Shapiro
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Prophylactic Phenytoin

Journal of Neurosurgery, 1984
W F, Bouzarth, H W, Goldman
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Phenytoin Hypersensitivity

JAMA: The Journal of the American Medical Association, 1977
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