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Annals of Internal Medicine, 1985
Excerpt To the editor: The recent report of Kushnir and associates (1), which describes the case of a patient who developed hypothyroidism during phenytoin intoxication, is of interest and should a...
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Excerpt To the editor: The recent report of Kushnir and associates (1), which describes the case of a patient who developed hypothyroidism during phenytoin intoxication, is of interest and should a...
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Neurocritical Care, 2005
Phenytoin toxicity may result from intentional overdose, dosage adjustments, drug interactions, or alterations in physiology. Intoxication manifests predominantly as nausea, central nervous system dysfunction (particularly confusion, nystagmus, and ataxia), with depressed conscious state, coma, and seizures occurring in more severe cases.
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Phenytoin toxicity may result from intentional overdose, dosage adjustments, drug interactions, or alterations in physiology. Intoxication manifests predominantly as nausea, central nervous system dysfunction (particularly confusion, nystagmus, and ataxia), with depressed conscious state, coma, and seizures occurring in more severe cases.
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Clinical Pharmacology & Therapeutics, 1978
I wish to point out a significant error in the article by Peter W. Mullen, “Optimal phenytoin therapy: A new technique for individualizing dosage,” which appeared on page 228 of the February, 1978, issue of the Journal. In Table I, the serum phenytoin concentrations he predicted by using the method described by Ludden and colleagues (Clin.
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I wish to point out a significant error in the article by Peter W. Mullen, “Optimal phenytoin therapy: A new technique for individualizing dosage,” which appeared on page 228 of the February, 1978, issue of the Journal. In Table I, the serum phenytoin concentrations he predicted by using the method described by Ludden and colleagues (Clin.
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Therapeutic Drug Monitoring, 1986
Numerous letters and reports located in the Parke, Davis and Smithsonian files add to the story of Merritt's and Putnam's discovery of the anticonvulsant (AC) properties of phenytoin. The major events preceding this work were the fortuitous discovery of phenobarbital as an AC agent, structure/hypnotic activity studies with barbiturates and hydantoins ...
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Numerous letters and reports located in the Parke, Davis and Smithsonian files add to the story of Merritt's and Putnam's discovery of the anticonvulsant (AC) properties of phenytoin. The major events preceding this work were the fortuitous discovery of phenobarbital as an AC agent, structure/hypnotic activity studies with barbiturates and hydantoins ...
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Phenytoin‐Lipid Conjugates as Potential Prodrugs of Phenytoin
Archiv der Pharmazie, 1993AbstractPhenytoin‐1‐triglycerides and phenytoin‐2‐triglycerides were synthesized as potential prodrugs of phenytoin by covalent binding of 3‐hydroxymethylphenytoin by succinic acid to the positions 1 and 2 of diglycerides, respectively. The corresponding 1‐ and 2‐monoglycerides were prepared.
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[Phenytoin and phenytoin derivatives for local administration].
Die Pharmazie, 1992A well known side effect of the long-term therapy with phenytoin is gum hyperplasia. 1-Acyl compounds and esters of the p-hydroxymetabolite with aliphatic and aromatic carboxylic acids were synthesized as potential prodrugs for therapeutic use if the neoformation of connective tissue is intended.
W, Fürst, R, Wildner
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Journal of Allergy and Clinical Immunology, 1980
S H, Josephs, S J, Rothman, R H, Buckley
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S H, Josephs, S J, Rothman, R H, Buckley
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