Results 181 to 190 of about 5,603 (210)

Characteristics of photosensitization of Pheophorbide a in liposomal media

Science in China Series C: Life Sciences, 1999
Pheophorbide a (PPa), a decomposition product of chlorophyll a, is a photosensitizer. The photosensitization mechanisms (Type I and Type 11) of PPa in simple buffer solutions and in buffer solutions containing double-layered DPPC liposomes have been studied using techniques of ESR, spin-trapping, spin-counteraction and laser flash photolysis.
H, Yang, M, Li, W, Zhang, H, Zhao, Z, Zhang   +4 more
openaire   +2 more sources

Synthesis of boronated derivatives of pheophorbide a

Doklady Chemistry, 2008
294 Photodynamic therapy (PDT) [1] and boron neutron capture therapy (BNCT) [2] are promising clinical approaches enabling a local effect on a tumor with little if any damage to the healthy tissue around it. Both methods are based on the selective accumulation of photoand radiosensitizer in cancer cells and in situ production of high-energy particles ...
V. A. Ol’shevskaya, A. V. Zaitsev, A. N. Savchenko, E. G. Kononova, P. V. Petrovskii, V. N. Kalinin   +5 more
openaire   +1 more source

The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy

Current Medicinal Chemistry, 2012
Pheophorbide a is a clorophyll catabolite that recently has drawn the attention of several investigators for its potential in photodynamic therapy. In this review we summarize its photophysical properties, phototoxicity, cellular localization, biodistribution and PDT activity as a free or conjugated molecule.
Xodo L. E., Rapozzi V., ZACCHIGNA, MARINA, DRIOLI, Sara, ZORZET, SONIA   +4 more
openaire   +3 more sources

Pheophorbide A from Solanum diflorum Interferes with NF-κB Activation

Planta Medica, 2001
Continuing our search for biogenic NF-kappa B inhibitors we investigated Solanum diflorum, used by the Istmo Sierra Zapotec Indians of Mexico in the treatment of inflammatory skin conditions. It became obvious very early that the active substance seems to be a degradation product of chlorophyll. Pheophorbide A was identified as one of the key compounds
Heinrich, Michael, Bork, P M, Schmitz, M L, Rimpler, H, Frei, B, Sticher, O   +5 more
openaire   +3 more sources

Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses

Journal of Natural Medicines, 2010
In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (HSV-2), influenza A virus (IFV-A)], and one non-enveloped virus [poliovirus type 1 (PV-1)].
Lamjed, Bouslama, Kyoko, Hayashi, Jung-Bum, Lee, Abdelwahed, Ghorbel, Toshimitsu, Hayashi   +4 more
openaire   +2 more sources

Evaluation of 99mTc-Pheophorbide-a use in infection imaging: A rat model

Applied Radiation and Isotopes, 2011
This study aims to prepare (99m)Technetium Pheophorbide-a ((99m)Tc-PH-A) complex and evaluate its efficiency as an infection imaging agent. First, PH-A was obtained from Spirulina maxima algae, and the product compound was confirmed using (1)H NMR and MS (ESI) methods.
Ocakoglu, Kasim, Bayrak, Elif, Onursal, Mehmet, Yilmaz, Osman, Lambrecht, Fatma Yurt, Holzwarth, Alfred R.   +5 more
openaire   +3 more sources

Transesterification of Exocyclic Ester Group of Methyl Pheophorbide a

Russian Journal of General Chemistry, 2019
The reaction of methyl pheophorbide a with various alcohols in toluene in the presence of dimethylaminopyridine as a base was investigated. Under these conditions, a chemoselective transesterification of the exocyclic ring proceeds without the use of an activating agent (N-methyl-2-chloropyridinium iodide) or a catalyst (molecular iodine).
L. A. Tulaeva, N. V. Gileva, D. V. Belykh   +2 more
openaire   +1 more source

Effective photocleavage of DNA by pheophorbide a.

Nucleic acids symposium series, 1992
Remarkably effective photocleavage of plasmid DNA with pheophorbide a, as a visible light sensitizer, has been found for the first time. DNA is photocleaved even in the absence of oxygen. The novel oxygen-independent scission is ascribed to specific photodynamic function of the ring V in pheophorbide a.
M, Kobayashi, M, Harada, M, Komiyama
openaire   +1 more source

Silkworm-pheophorbide a mediated photodynamic therapy against B16F10 pigmented melanoma

Journal of Photochemistry and Photobiology B: Biology, 2004
In order to apply photodynamic therapy (PDT) to pigmented melanoma, the efficacy of PDT mediated by pheophorbide alpha from silkworm excreta (SPbalpha) and commercial Photofrin against B16F10 melanoma was comparatively studied from the in vivo assay using C57BL/6J mice.
Dae-Seog, Lim, Si-Hwan, Ko, Won-Young, Lee   +2 more
openaire   +2 more sources

Pheophorbide a-methyl ester, acyl-coa: cholesterol acyltransferase inhibitor fromDiospyros kaki

Archives of Pharmacal Research, 2003
In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester.
Mun-Chual, Rho, Mi Yeon, Chung, Hye Young, Song, Oh Eok, Kwon, Seung Woong, Lee, Jin Ah, Baek, Kyung Hee, Jeune, Koanhoi, Kim, Hyun Sun, Lee, Young Kook, Kim   +9 more
openaire   +2 more sources