Results 161 to 170 of about 3,607 (204)

Synthesis of pheophorbide-a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents

Bioorganic and Medicinal Chemistry, 2011
Pheophorbide-a, a chlorine based photosensitizer known to be selectively accumulated in cancer cells, was conjugated with anticancer drugs, doxorubicin and paclitaxel in the purpose of selective cancer diagnosis and therapy. Pheophorbide-a was conjugated
Hyo-Eun Yoon, Jung-Hoon Yoon, Hyojin Ko   +2 more
exaly   +2 more sources

Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator [PDF]

Biomedicine and Pharmacotherapy, 2022
The lymphatic vascular system is crucial for maintaining tissue fluid homeostasis and immune surveillance. Promoting lymphatic function represents a new strategy to treat several diseases including lymphedema, chronic inflammation and impaired wound ...
Jihye Kim, Epameinondas Gousopoulos, Matthias Hamburger   +2 more
exaly   +2 more sources

Zinc-pheophorbide a—Highly efficient low-cost photosensitizer against human adenocarcinoma in cellular and animal models

Photodiagnosis and Photodynamic Therapy, 2013
Background Our previous study has shown a prolonged retention and accumulation of Zn-pheophorbide a, a water-soluble derivative of chlorophyll a, in tumor tissue (Szczygiel et al. [19]).
Monika A Jakubowska, Małgorzata Szczygieł, Dominika Michalczyk-Wetula   +2 more
exaly   +2 more sources

Pheophorbide-a conjugates with cancer-targeting moieties for targeted photodynamic cancer therapy

Bioorganic and Medicinal Chemistry, 2015
Pheophorbide-a, a non-selective photosensitizer, was conjugated with cancer-targeting moieties, such as folic acid, the CRGDLASLC peptide, the cRGDfK peptide and leuprorelin, for the purpose of targeted photodynamic cancer therapy. The cellular uptake of
Hyo-Eun Yoon, Hyojin Ko, Jung-Hoon Yoon   +2 more
exaly   +2 more sources

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The synthesis of galactopyranosyl-substituted derivatives of pheophorbide

Russian Journal of Bioorganic Chemistry, 2000
New pheophorbide and pyropheophorbide derivatives containing carbohydrate fragments, derivatives of galactopyranose, were synthesized. Galactopyranosylpheophorbide and galactopyranosylpyropheophorbide with free hydroxyl groups were found to be water-soluble and useful as sensitizers in photodynamic therapy of cancer.
A A, Aksenova, Iu L, Sebiakin, A F, Mironov   +2 more
openaire   +2 more sources

Energy and electron transfer properties of methyl pheophorbide-a in zinc porphyrin-pheophorbide dyads

Tetrahedron, 1997
Abstract A series of ortho-, meta- and para-substituted zinc porphyrin-pheophorbide dyads were synthesized directly from methyl pheophorbide-a by trans-esterification of β-keto methyl ester with hydroxymethyl substituted porphyrins. Quantitative energy transfer occurred from the excited zinc porphyrin to the pheophorbide.
Satoshi Shinoda, Hiroshi Tsukube, Yoshinobu Nishimura, Iwao Yamazaki, Atsuhiro Osuka   +4 more
openaire   +1 more source

Characteristics of photosensitization of Pheophorbide a in liposomal media

Science in China Series C: Life Sciences, 1999
Pheophorbide a (PPa), a decomposition product of chlorophyll a, is a photosensitizer. The photosensitization mechanisms (Type I and Type 11) of PPa in simple buffer solutions and in buffer solutions containing double-layered DPPC liposomes have been studied using techniques of ESR, spin-trapping, spin-counteraction and laser flash photolysis.
H, Yang, M, Li, W, Zhang, H, Zhao, Z, Zhang   +4 more
openaire   +2 more sources

Derivatives of Pheophorbide‐a and Pheophorbide‐b from Photocytotoxic Piper penangense Extract

Chemistry & Biodiversity, 2011
AbstractIn our screening program for new photosensitizers from Malaysian biodiversity for photodynamic therapy (PDT) of cancer, MeOH extracts of ten terrestrial plants from Cameron Highlands in Pahang, Peninsular Malaysia, were tested. In a short‐term 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay, 20 μg/ml each of these ...
Fadzly Adzhar, Kamarulzaman, Khozirah, Shaari, Anthony Siong Hock, Ho, Nordin Haji, Lajis, Soo Hwang, Teo, Hong Boon, Lee   +5 more
openaire   +2 more sources

Photodynamic Imaging of a Rat Pancreatic Cancer with Pheophorbide a

Photochemistry and Photobiology, 1996
ABSTRACTLaser‐induced fluorescence of pheophorbide a (Ph‐a) was used for in vitro photodynamic imaging (PDI) of a rat pancreatic acinar tumor. A 400 nm excitation induced a 470 nm autofluorescence and a 678 nm dye fluorescence in tumors and their surrounding pancreas 24 h after a 9 mg kg−1 body weight Ph‐a intravenous administration.
Keller, P., Sowinska, M., Tassetti, V., Heisel, F., Hajri, A., Evrard, S., Miehe, J.A., Marescaux, J., Aprahamian, M.   +8 more
openaire   +3 more sources

Synthesis of boronated derivatives of pheophorbide a

Doklady Chemistry, 2008
294 Photodynamic therapy (PDT) [1] and boron neutron capture therapy (BNCT) [2] are promising clinical approaches enabling a local effect on a tumor with little if any damage to the healthy tissue around it. Both methods are based on the selective accumulation of photoand radiosensitizer in cancer cells and in situ production of high-energy particles ...
V. A. Ol’shevskaya, A. V. Zaitsev, A. N. Savchenko, E. G. Kononova, P. V. Petrovskii, V. N. Kalinin   +5 more
openaire   +1 more source