Results 221 to 230 of about 8,721 (232)

Abstract 5417: PHGDH expression level impacts tumorigenesis and metastasis in human breast cancer

Cancer Research
Background: Phosphoglycerate dehydrogenase (PHGDH) is a metabolic enzyme, which is associated with the first step of serine synthesis. The gene encoding this enzyme is often elevated in some types of human cancer, including breast cancer.
Jihong Baik, Juhee Kim, Sangeun Lee, A. Park, Kyoungseob Shin, Sunghoon Kwon, Han-Byoel Lee, Wonshik Han   +7 more
semanticscholar   +1 more source

Abstract 1591: Hepatocytes compensate for the loss of PHGDH in pancreatic cancer cells during liver metastasis

Cancer Research
Background: Pancreatic cancer (PC), one of the deadliest malignancies, exhibits a high rate of distant metastasis that directly correlates with the mortality rate. Liver serves as one of the most predominant sites of metastasis in PC patients.
Koelina Ganguly, Keisuke Yamamoto, Joel Encarnacion Rosado, Albert Sohn, Douglas E. Biancur, Elaine Lin, Elshadai White, Alec C Kimmelman   +7 more
semanticscholar   +1 more source

Abstract 3275: PHGDH-mediated serine-glycine-one-carbon metabolism drives ferroptosis- and chemotherapy-resistance in colorectal cancer

Cancer Research
Background and Aim: Ferroptosis is an iron-dependent form of programmed cell death characterized by lipid peroxidation, with the potential as a novel cancer therapy. The application of ferroptosis-inducers has been limited to preclinical studies due to
Guanzhan Liang, Jing Chen, Xiaofeng Wen, Zong-cai Zhang, Zexian Chen, Yongle Chen, Zhenyu Xian, Xiao-wen He, Xianrui Wu, Ping Lan, Tuo Hu   +10 more
semanticscholar   +1 more source

KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner

Molecular and Cellular Biochemistry, 2023
Xin-yu Wang, Hong-ming Li, Ran Xia, Xia Li, Xing Zhang, Tong-Zhao Jin, Hong-Sheng Zhang   +6 more
semanticscholar   +1 more source

Competition between p53 and YY1 determines PHGDH expression and malignancy in bladder cancer

Cellular Oncology, 2023
Tiezhu Shi, Zhihao Yuan, Yanying He, Dongliang Zhang, Siteng Chen, Xiongjun Wang, Linli Yao, J. Shao, Xiang Wang   +8 more
semanticscholar   +1 more source

PHGDH/SYK: a hub integrating anti-fungal immunity and serine metabolism

Cell Death and Differentiation
Xinyong Zhang, Dongdong Hu, Xiaoyan Sun, Yichun Gu, Yong Zhou, Chuanxin Su, Shi Liu, Caiyan Zhang, Guoping Lu, Qiwen Wu, Aidong Chen   +10 more
semanticscholar   +1 more source

Increased Expression of PHGDH Under High-Selenium Stress In Vivo

Biological Trace Element Research
Qin Wang, Jianrong Wang, Xue Zhang, Yiqun Liu, F. Han, Xuesong Xiang, Yanbin Guo, Zhenwu Huang   +7 more
semanticscholar   +1 more source

Artesunate attenuates serum amyloid A-induced M1 macrophage differentiation through the promotion of PHGDH.

International Immunopharmacology, 2023
Xinhui Lu, Yan Huang, Mingqian Zhou, Yixuan Guo, Yihan Zhou, Rongyun Wang, Wumeng Jin, Chengping Wen, Yun Zhang, Yujun Tang   +9 more
semanticscholar   +1 more source

Multi-omics analysis reveals GAPDH posttranscriptional regulation of IFN-γ and PHGDH as a metabolic checkpoint of microglia polarization

Brain, behavior, and immunity
Shangchen Yang, Ziqi Yuan, Yufei Zhu, Chensi Liang, Zhenlei Chen, Jie Zhang, Lige Leng   +6 more
semanticscholar   +1 more source

ATF4/PHGDH mediates the effects of ER stress on Cadmium-induced autophagy and glycolysis.

Toxicology
Yanqiu Yang, Shengnan Li, Yuanxi Yang, Qiujuan Li, Yong Liu, Jun Cao   +5 more
semanticscholar   +1 more source