Results 41 to 50 of about 8,721 (232)

Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation

Molecular Oncology, 2020
d‐3‐Phosphoglycerate dehydrogenase (PHGDH) conducts an important step in the synthesis of serine. Importantly, the PHGDH gene is often amplified in certain cancers.
Hirofumi Yoshino, Hideki Enokida, Yoichi Osako, Nijiro Nohata, Masaya Yonemori, Satoshi Sugita, Kazuki Kuroshima, Masafumi Tsuruda, Shuichi Tatarano, Masayuki Nakagawa   +9 more
doaj   +1 more source

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [PDF]

, 2015
Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH ...
Abu-Remaileh, Monther, Chan, Sze Ham, Chen, Walter W., Cho, Sung Won, Chung, Haeyoon, Davidson, Shawn M, Fiske, Brian Prescott, Koh, Min Jung, Lewis, Caroline, Liu, Chieh Ming Jamin, Luengo, Alba, Pacold, Michael Edward, Sabatini, David, Sullivan, Lucas Bryan, Swier, Lotteke J. Y. M., Vander Heiden, Matthew G., Zhou, Minerva H.   +16 more
core   +1 more source

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer [PDF]

, 2010
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and ...
A Bric, A Marson, Abhishek K. Jha, Albert M. Chan, B Luo, Bingbing Yuan, D Wiederschain, DA Walsh, David E. Root, David M. Sabatini, Dohoon Kim, DR Rhodes, Edward M. Driggers, Elena F. Brachtel, FR Miller, FR Miller, Francesca G. Barrett, Glenn S. Cowley, Hin-Koon Woo, Hyun G. Jang, I Ben-Porath, J Debnath, J Kim, J Moffat, JM Buescher, Jordi Barretina, K Lund, K Snell, Kathleen Ottina, Kevin M. Marks, Kıvanç Birsoy, Levi A. Garraway, Mari Mino-Kenudson, Michael E. Pacold, MJ van de Vijver, Nada Y. Kalaany, Nicolas Stransky, NY Kalaany, Peggy P. Hsu, PP Hsu, R Beroukhim, RG Jones, Richard Possemato, RJ DeBerardinis, S Pollari, Shalini Sethumadhavan, TS Mikkelsen, Walter W. Chen, WE Knox, Y Achouri, Y Sancak, Yoav D. Shaul, Zhi-Yang Tsun   +52 more
core   +1 more source

Cancer metabolism: Addicted to serine. [PDF]

, 2016
Cancer cells are biosynthetic factories that gear multiple metabolic pathways toward cell growth and proliferation. Serine is the metabolite consumed third most by cancer cells, after glucose and glutamine, and is used as a building block for proteins ...
Frezza, Christian
core   +2 more sources

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis [PDF]

, 2010
Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood [1, 2].
Adam J Bass, AL Richardson, Alexandra R Grassian, Andrea L Richardson, Atsuo T Sasaki, Azra H Ligon, CA Fernandez, CB Thompson, CH Eng, Christian M Metallo, Costas A Lyssiotis, Dimitrios Anastasiou, DJ Slamon, DK Nomura, DR Rhodes, Edouard Mullarky, G Bodenhausen, Gerhard Wagner, Gregory Heffron, Gregory Stephanopoulos, H Bismut, Hadar Sharfi, J Debnath, J Greshock, J Luo, Jason W Locasale, Joan S Brugge, John M Asara, JW Locasale, K Hara, K Hoek, K Snell, Katherine R Mattaini, L Tabatabaie, Lewis C Cantley, Lynda Chin, Matthew G Vander Heiden, Matthew Meyerson, MG Vander Heiden, MG Vander Heiden, Mika Sasaki, MR Antoniewicz, Natalie I Vokes, O Warburg, R Beroukhim, R Teperino, Rameen Beroukhim, RJ DeBerardinis, S Kit, S Pollari, Tamar Melman, Taru Muranen, TJ de Koning, W Lu, WD Foulkes, Y Achouri, ZT Schafer   +56 more
core   +1 more source

Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?

Cell Death Discovery, 2021
To sustain their malignancy, tumour cells acquire several metabolic adaptations such as increased oxygen, glucose, glutamine, and lipids uptake. Other metabolic processes are also enhanced as part of tumour metabolic reprogramming, for example, increased
Megan Jessica McNamee, David Michod, Maria Victoria Niklison-Chirou   +2 more
doaj   +1 more source

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth [PDF]

, 2016
We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombinant ...
A Bassols, A Conesa, A Méndez-Lucas, AA Sneddon, AM Gunawan, B Sève, C Chaosap, C Kung, CP Velloso, DM Brown, DM Spurlock, EE Vincent, FA Wilson, FFS Depreux, FR Dunshea, GM DeNicola, GS Lynch, H Rhinn, J Bush, J Yang, J Ye, JA Bush, JA Higgins, JK Apple, JM Brameld, JW Locasale, JW Locasale, K Leithner, KM Hemmings, L Norton, L Sun, M Ruusunen, M Sandri, M Vestergaard, MA Pearen, MT Sørensen, O Bohorov, PJ Buttery, PJ Reeds, PM Tedeschi, PS Ward, PW Emery, R Koopman, R Possemato, RG Campbell, RJ DeBerardinis, RJ Samms, S Bardocz, S Modaressi, SA Gahr, SC Kalhan, SY Lunt, T Kitaura, T Laeger, T Parr, TA Armstrong, TJ Caperna, WO Kline, YR Boisclair   +58 more
core   +3 more sources

PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma. [PDF]

Cell Death Dis
Osteosarcoma is a bone cancer that has been found to be metabolically dependent on the conversion of glucose to serine through the rate-limiting enzyme 3-phosphoglycerate dehydrogenase (PHGDH).
Oyama T, Brashears CB, Rathore R, Benect-Hamilton H, Caldwell KE, Dirckx N, Hawkins WG, Van Tine BA.   +7 more
europepmc   +2 more sources

Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene [PDF]

, 2014
Exemplified by cancer cells' preference for glycolysis, for example, the Warburg effect, altered metabolism in tumorigenesis has emerged as an important aspect of cancer in the past 10–20 years.
Zogg, Cheryl K.
core   +3 more sources

MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury. [PDF]

Cell Discov
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and poses a significant clinical challenge in both diagnosis and treatment.
Xing R, Liu R, Man Y, Liu C, Zhang Y, Gao H, Yang W.   +6 more
europepmc   +2 more sources