Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease [PDF]
Nature Metabolism, 2021 Macular telangiectasia type 2 (MacTel) is a progressive, late-onset retinal degenerative disease linked to decreased serum levels of serine that elevate circulating levels of a toxic ceramide species, deoxysphingolipids (deoxySLs); however, causal genetic variants that reduce serine levels in patients have not been identified.
Kevin Eade +19 more
openaire +2 more sources
One-carbon metabolism in cancer [PDF]
, 2017 Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane +55 more
core +1 more source
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]
, 2016 Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel +4 more
core +1 more source
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [PDF]
, 2015 Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH ...
Abu-Remaileh, Monther +16 more
core +1 more source
Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer [PDF]
, 2010 Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and ...
A Bric +52 more
core +1 more source
Cancer metabolism: Addicted to serine. [PDF]
, 2016 Cancer cells are biosynthetic factories that gear multiple metabolic pathways toward cell growth and proliferation. Serine is the metabolite consumed third most by cancer cells, after glucose and glutamine, and is used as a building block for proteins ...
Frezza, Christian
core +2 more sources
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth [PDF]
, 2016 We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombinant ...
A Bassols +58 more
core +3 more sources
Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways [PDF]
, 2019 The epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) control the epithelial-to-mesenchymal transition (EMT) splicing program in cancer. However, their role in breast cancer recurrence is unclear. In this study, we report that high levels
Badve, Sunil S. +9 more
core +1 more source
Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?
Cell Death Discovery, 2021 To sustain their malignancy, tumour cells acquire several metabolic adaptations such as increased oxygen, glucose, glutamine, and lipids uptake. Other metabolic processes are also enhanced as part of tumour metabolic reprogramming, for example, increased
Megan Jessica McNamee +2 more
doaj +1 more source
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis [PDF]
, 2010 Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood [1, 2].
Adam J Bass +56 more
core +1 more source