Results 21 to 30 of about 74,576 (156)

Efficacy and safety of low‐dose imatinib in an elderly patient with mixed phenotype acute leukemia with t(9;22)(q34;q11.2);BCR‐ABL1

Clinical Case Reports, 2021
Low‐dose imatinib with monitoring of drug concentrations in blood may successfully control Philadelphia chromosome‐positive mixed phenotype acute leukemia (Ph+MPAL), particularly in elderly patients with comorbidities.
Yusuke Okayama, Teruhito Takakuwa, Ippei Otomaru, Mirei Horiuchi, Akiko Miura, Taku Araki, Yotaro Fujitani, Ryosuke Yamamura   +7 more
doaj   +1 more source

Response to “Philadelphia chromosome?” [PDF]

American Journal of Hematology, 2006
WOS ...
openaire   +2 more sources

Autologous transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia achieves outcomes similar to allogeneic transplantation: results of CALGB Study 10001 (Alliance)

Haematologica, 2014
Allogeneic stem cell transplantation is the standard approach to Philadelphia chromosome positive acute lymphoblastic leukemia. We hypothesized that imatinib plus sequential chemotherapy will result in significant leukemia cell cytoreduction in patients ...
Meir Wetzler, Dorothy Watson, Wendy Stock, Gregory Koval, Flora A. Mulkey, Eva E. Hoke, John M. McCarty, William G. Blum, Bayard L. Powell, Guido Marcucci, Clara D. Bloomfield, Charles A. Linker, Richard A. Larson   +12 more
doaj   +1 more source

Modeling Philadelphia chromosome positive leukemias [PDF]

Oncogene, 2001
The Ph chromosome has been genetically linked to CML and ALL. Its chimeric fusion gene product, BCR-ABL, can generate leukemia in mice. This review will discuss selected model systems developed to study BCR-ABL induced leukemia and focuses on what we have learned about the human disease from these models.
S, Wong, O N, Witte
openaire   +2 more sources

Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia

Haematologica, 2019
To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leukemia and to investigate the prognostic role of additional genomic lesions, we analyzed copy number aberrations using the Cytoscan HD Array in 116 newly ...
Anna Lucia Fedullo, Monica Messina, Loredana Elia, Alfonso Piciocchi, Valentina Gianfelici, Alessia Lauretti, Stefano Soddu, Maria Cristina Puzzolo, Clara Minotti, Felicetto Ferrara, Bruno Martino, Patrizia Chiusolo, Valeria Calafiore, Stefania Paolini, Marco Vignetti, Antonella Vitale, Anna Guarini, Robin Foà, Sabina Chiaretti   +18 more
doaj   +1 more source

Philadelphia chromosome-positive Acute Lymphoblastic Leukemia [PDF]

Hematology, 2015
Philadelphia chromosome-positive Acute Lymphoblastic ...
FORGHIERI, Fabio, LUPPI, Mario, POTENZA, Leonardo   +2 more
openaire   +3 more sources

Mutations Associated with Imatinib Mesylate Resistance - Review

Folia Medica, 2018
Chronic myeloid leukemia (CML) arises from the fusion of the BCR and the ABL1 genes. The BCR gene (chromosome 22q11.2) and the ABL1 gene (chromosome 9q34) fuse together due to reciprocal chromosome translocation forming the Philadelphia chromosome (Ph ...
Linev Alexandar J., Ivanov Hristo J., Zhelyazkov Ivan G., Ivanova Hristina, Goranova-Marinova Veselina S., Stoyanova Vili K.   +5 more
doaj   +1 more source

BCR/ABL1 fluorescence in situ hybridization fusion signals on both copies of chromosome 22 in a Philadelphia-masked chronic myeloid leukemia case: implication for the therapy

Hematology Reports, 2021
The cytogenetic hallmark of Chronic Myeloid Leukemia (CML) is the presence of Philadelphia (Ph) chromosome, which results from a reciprocal translocation t(9;22)(q34;q11).
Silvia Soriani, Valentina Guido, Giambattista Bertani, Clara Cesana, Valentina Motta, Gabriella De Canal, Elena De Paoli, Silvio Veronese, Emanuela Bonoldi, Lorenza Romitti   +9 more
doaj   +1 more source

Philadelphia chromosome duplication as a ring-shaped chromosome [PDF]

Molecular Cytogenetics, 2016
La obtención de una segunda copia del cromosoma Filadelfia es uno de los principales cambios cromosómicos secundarios relacionados con la evolución clonal de las células con t(9;22) en la leucemia mielógena crónica. Esta ganancia provoca la adquisición de otra copia del gen de fusión BCR/ABL1.
César Borjas-Gutiérrez, Juan Ramón González-García   +1 more
openaire   +2 more sources

“Preleukemic or smoldering” chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report

Leukemia Research Reports, 2015
Chronic myelogenous leukemia (CML), in the Chronic Phase (CP), is often suspected as a result of a complete blood count (CBC), which shows increased granulocytes, mostly mature including a peak in myelocytes, increased basophils, and rarely blasts and/or
John M. Bennett, Kevin G. Dsouza, Mehul Patel, Kristen O’Dwyer   +3 more
doaj   +1 more source