Results 21 to 30 of about 886,649 (291)
The Philadelphia chromosome in human macrophages [PDF]
Blood, 1977 Three patients with chronic myelocytic leukemia in different phases of the natural history of the disease were studied. Their bone marrow cells were cultured under conditions favoring macrophage proliferation, and parallel cytogenetic and cytochemical studies were performed.
Carmen Burgaleta +3 more
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Asian Pacific Journal of Cancer Care, 2021 Background and Purpose: Chronic Myeloid Leukemia (CML) is a common hematological malignancy. The characteristic molecular abnormality is the presence of Philadelphia chromosome or BCR-ABL fusion gene which is the result of 9:22 translocation.
Shafaq Maqsood +3 more
doaj +1 more source
JAMA Oncology, 2020 Importance A randomized clinical trial is needed to determine whether the second-generation Abl-tyrosine kinase inhibitor dasatinib is more effective than the first-generation inhibitor imatinib mesylate for childhood Philadelphia chromosome-positive ...
S. Shen +30 more
semanticscholar +1 more source
Applying the discovery of the Philadelphia chromosome [PDF]
Journal of Clinical Investigation, 2007 The identification of the Philadelphia chromosome in cells from individuals with chronic myelogenous leukemia (CML) led to the recognition that the BCR-ABL tyrosine kinase causes CML. This in turn led to the development of imatinib mesylate, a clinically successful inhibitor of the BCR-ABL kinase.
Brian J. Druker, Daniel W. Sherbenou
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Revista Brasileira de Hematologia e Hemoterapia, 2015 Background: Chronic myeloid leukemia is a myeloproliferative disorder characterized by the Philadelphia chromosome or t(9;22)(q34.1;q11.2), resulting in the break-point cluster regionAbelson tyrosine kinase fusion gene, which encodes a constitutively ...
Maria de Lourdes Lopes Ferrari Chauffaille +2 more
doaj +1 more source
New England Journal of Medicine, 2001 BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is present in virtually all cases of chronic myeloid leukemia (CML) throughout the course of the disease, and in 20 percent of ...
B. Druker +7 more
semanticscholar +1 more source
JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2011 Myeloproliferative neoplasms (MPNs) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients ...
Mehrdad Payande +3 more
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The legacy of the Philadelphia chromosome [PDF]
Journal of Clinical Investigation, 2007 The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to cancer. As with most seminal scientific observations, the description of the Philadelphia chromosome posed many more questions than were answered.
openaire +3 more sources
International Journal of Medical Students, 2015 Background: Treatment for adult Philadelphia chromosome+ acute lymphoblastic leukemia includes using dasatinib, a tyrosine kinase inhibitor. Cutaneous squamous cell carcinomas and keratoacanthomas are common findings in patients treated with BRAF ...
Siddhant Thukral +3 more
doaj +1 more source
Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.
Blood, 1975 A cell-line derived from a patient with chronic myelogenous leukemia (CML) is described. The new cell-line, which has over 175 serial passanges in a 3 1/2-yr period, has the following characteristics: (1) CML cells started to proliferate actively since ...
C. Lozzio, B. Lozzio
semanticscholar +1 more source