Results 61 to 70 of about 26,986 (167)

Lettuce Big‐Vein Associated Virus ORF3 Encodes a Functional 30K Movement Protein

Molecular Plant Pathology, Volume 26, Issue 9, September 2025.
AlphaFold2 + FoldSeek structure guided search predicts the movement protein of lettuce big‐vein associated virus despite low sequence similarity. ABSTRACT Movement proteins (MPs) modulate the size exclusion limit of plasmodesmata—membrane‐lined channels connecting plant cells—thereby allowing cell‐to‐cell movement and systemic spread of plant viruses ...
Willem E. W. Schravesande, Machiel V. Cligge, Raoul Frijters, Adriaan Verhage, Harrold A. van den Burg   +4 more
wiley   +1 more source

Comprehensive evaluation of nucleic acid amplification methods widely used for generic detection of sandfly-borne phleboviruses

Microbiology Spectrum
Sandfly-borne phleboviruses (SBPs), which cause sandfly fever, aseptic meningitis, encephalitis, and meningoencephalitis, are emerging pathogens of major public health concern.
Ceylan Polat, Nazli Ayhan, Koray Ergünay, Remi N. Charrel   +3 more
doaj   +1 more source

Medicinal Plant‐Derived Caffeoylquinic Acids as Inhibitors of Rift Valley Fever Virus: A Computational Study

ChemistrySelect, Volume 10, Issue 12, March 26, 2025.
Caffeoylquinic acids derived from medicinal plants were evaluated for their potential as inhibitors of the Rift Valley Fever Virus, specifically targeting the LRP1‐CR17 protein. The study employed DFT, molecular docking, and molecular dynamics simulations to analyze these compounds. The results showed strong binding affinities to the LRP1‐CR17 receptor,
Garland K. More, Charmy Twala, Kgaugelo C. Tapala, Raymond T. Makola, Gerhard Prinsloo   +4 more
wiley   +1 more source

Clinical review of Toscana virus: a Mediterranean Neuroinvasive Phlebovirus

Frontiers in Epidemiology
Toscana virus (TOSV) is a sandfly-transmitted phlebovirus of the family Phenuiviridae and a leading cause of summer meningitis and meningoencephalitis in the Mediterranean basin. It was first isolated in 1971 from Phlebotomus perniciosus in central Italy
Ahmad Makky, Parham Elahi, Hadi Awali
doaj   +1 more source

Overview of West Nile Virus and Sandfly-borne Phlebovirus Infections in Anatolia

Journal of Microbiology and Infectious Diseases, 2014
Arthropod-borne (arbo) viruses are trafinsmitted to the susceptible hosts by blood-feeding arthropods such as mosquitoes, sandflies and ticks. Arboviral infections have had a significant global public health impact during the last decades due to their ...
Koray Ergunay, Zeliha Kocak Tufan
doaj   +1 more source

Establishment of an Early Prediction Model for Severe Fever With Thrombocytopenia Syndrome‐Associated Encephalitis

Immunity, Inflammation and Disease, Volume 12, Issue 12, December 2024.
ABSTRACT Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease primarily transmitted by ticks. The development of encephalitis in SFTS patients significantly increases the risk of adverse outcomes. However, the understanding of SFTS‐associated encephalitis (SFTSAE) is still limited. This study aimed to identify
Yijiang Liu, Naisheng Zhu, Zimeng Qin, Chenzhe He, Jiaqi Li, Hongbo Zhang, Ke Cao, Wenkui Yu   +7 more
wiley   +1 more source

Single-Dose Intranasal Treatment with DEF201 (Adenovirus Vectored Consensus Interferon) Prevents Lethal Disease Due to Rift Valley Fever Virus Challenge

Viruses, 2014
Rift Valley fever virus (RVFV) causes severe disease in humans and ungulates. The virus can be transmitted by mosquitoes, direct contact with infected tissues or fluids, or aerosol, making it a significant biological threat for which there is no approved
Brian B. Gowen, Jane Ennis, Kevin W. Bailey, Zachary Vest, Dionna Scharton, Eric J. Sefing, Jeffrey D. Turner   +6 more
doaj   +1 more source

Early prognosis biomarkers of severe fever with thrombocytopenia syndrome

iLABMED, Volume 2, Issue 4, Page 341-351, December 2024.
SFTSV interacts with the host's immune defenses, prompting the engagement of both innate and adaptive immune responses by effector cells. This interaction ultimately results in the activation and proliferation of relevant cytokines. Abstract Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that results from SFTS ...
Mingrong Ou, Aofan Wang, Jie Yu, Liwei Zhao, Chuang Li, Yuanyuan Wu, Yuxin Chen   +6 more
wiley   +1 more source

Experimental Infection of Dogs with Toscana Virus and Sandfly Fever Sicilian Virus to Determine Their Potential as Possible Vertebrate Hosts

Microorganisms, 2020
The sandfly-borne Toscana phlebovirus (TOSV), a close relative of the sandfly fever Sicilian phlebovirus (SFSV), is one of the most common causes of acute meningitis or meningoencephalitis in humans in the Mediterranean Basin.
Clara Muñoz, Nazli Ayhan, Maria Ortuño, Juana Ortiz, Ernest A. Gould, Carla Maia, Eduardo Berriatua, Remi N. Charrel   +7 more
doaj   +1 more source

A cross‐sectional study on phlebotomine sand flies in relation to disease transmission in the Republic of Kosovo

Medical and Veterinary Entomology, Volume 38, Issue 4, Page 573-585, December 2024.
We provide the currently known sand fly distribution and species diversity in Kosovo, including a COI barcode inventory and distribution maps. Phlebotomus neglectus and Ph. perfiliewi were identified to be the predominant species and environmental analyses depicted two geographical groups of sand flies in Kosovo, with notable differences between the ...
Betim Xhekaj, Ina Hoxha, Katharina Platzgummer, Jovana Stefanovska, Vít Dvořák, Markus Milchram, Adelheid G. Obwaller, Wolfgang Poeppl, Nesade Muja‐Bajraktari, Julia Walochnik, Attila J. Trájer, Kurtesh Sherifi, Aleksandar Cvetkovikj, Edwin Kniha   +13 more
wiley   +1 more source